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Ectopeptidases pp 141-170 | Cite as

Signal Transduction Via Membrane Peptidases

  • Dagmar Riemann
  • Tanja Blosz
  • Jens Wulfänger
  • Jürgen Langner
  • Alexander Navarrete Santos
Chapter

Abstract

Human aminopeptidase N (APN)/CD13 is a type-II transmembrane molecule which belongs to a group of ectoenzymes with a ubiquitous expression and a broad functional repertoire. Other members of this group of membrane enzymes, which often are colocalized and which can cooperate in peptide cleavage are neprilysin/CD10, dipeptidyl peptidase IV (DPIV)/CD26, glutamyl aminopeptidase and angiotensin converting enzyme/CD143. Not only do these membrane peptidases hydrolyse small peptide mediators, resulting in activation or inactivation, but they also function as receptors and as molecules participating in cell motility and in adhesion to extracellular matrix. Membrane peptidases may play a key role in the control of growth and differentiation of various cellular systems by modulating the activity of peptides involved in growth and differentiation of cells and by regulating their access to adjacent cells. As an example, neprilysin can modulate proliferation of bronchial epithelial cells by cleavage of mitogenic bombesins (Ganju et al 1994). Expression of neprilysin is inversely correlated with proliferation in bronchial epithelial cells and lung cancer cells (Shipp et al 1991). It is also well known that the expression of DPIV is up-regulated following mitogenic activation (Schön et al 1985). Last not least, recent observations suggest direct involvement of membrane peptidases in signal transduction processes.

Keywords

Focal Adhesion Kinase Lipid Raft Dipeptidyl Peptidase Membrane Microdomains Neutral Endopeptidase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Dagmar Riemann
    • 1
  • Tanja Blosz
    • 1
  • Jens Wulfänger
    • 2
  • Jürgen Langner
    • 1
  • Alexander Navarrete Santos
    • 2
  1. 1.Institute of Medical ImmunologyMartin-Luther-University Halle-WittenbergHalle/SaaleGermany
  2. 2.ACGT Pro Genomics AGHalle/SaaleGermany

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