CD13/APN in Hematopoetic Cells — Expression, Function, Regulation, and Clinical Aspects

  • Uwe Lendeckel
  • Marco Arndt
  • Beate Firla
  • Carmen Wolke
  • Thomas Wex
  • Siegfried Ansorge


Alanyl aminopeptidase (aminopeptidase N, APN, CD13, EC is a 967 amino acid type II transmembrane protein which occurs on the cell surface of a broad variety of cells. The zinc-dependent metalloprotease (M1 family of peptidases, clan MA, gluzincins) (Hooper 1994, Rawlings and Barrett 1993) preferentially cleaves neutral amino acids from the N-terminus of oligopeptides. The human APN gene was cloned in 1989 and mapped to chromosome 15(q25–q26) (Look et al 1989, Watt and Willard 1990). The 3560 bp of coding sequence are scattered over 20 exons (Lerche et al. 1996).


Acute Myeloid Leukemia U937 Cell Hematopoetic Cell Aminopeptidase Inhibitor Human Coronavirus 229E 
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Copyright information

© Springer Science+Business Media New York 2002

Authors and Affiliations

  • Uwe Lendeckel
    • 1
  • Marco Arndt
    • 1
  • Beate Firla
    • 2
  • Carmen Wolke
    • 1
  • Thomas Wex
    • 3
  • Siegfried Ansorge
    • 1
  1. 1.Institute of Experimental Internal MedicineOtto-von-Guericke University MagdeburgMagdeburgGermany
  2. 2.Institute of ImmunologyOtto-von-Guericke University MagdeburgMagdeburgGermany
  3. 3.Clinic of GastroenterologyOtto-von-Guericke University MagdeburgMagdeburgGermany

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