The Role of NK Cells and T Cells in the Rejection of Embryonic Stem Cell-Derived Tissues

Chapter
Part of the Stem Cell Biology and Regenerative Medicine book series (STEMCELL)

Abstract

Embryonic stem (ES) cells provide a unique opportunity for the establishment of new cell-based therapies that could benefit human health in the future. However, before that step can be taken, we need to better understand how to manipulate the differentiation of stem cells into cell lineages of interest and to define the immunological characteristics of these cells in the context of allogeneic transplantation. Here, we will discuss the interaction of ES cell progenitors with alloreactive T cells and NK cells and discuss how low MHC expression by ES cell derivatives may be exploited for therapies in humans.

Keywords

Major Histocompatibility Complex Embryonic Stem Embryonic Stem Cell Human Leukocyte Antigen Major Histocompatibility Complex Class 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work would not have been possible without grants NIH/NHLBI 5R01HL073015-08 and the VA Merit Review Award 1I01BX001125-01

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Division of Allergy and Immunology, Department of Internal MedicineUniversity of Iowa Hospitals and Clinics, VAHCS lowa CityIowa CityUSA

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