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Fine Needle Aspiration Cytology

  • Robert A. SoffermanEmail author
Chapter

Abstract

The application of fine needle aspiration ­cytology to the management of thyroid disorders has an interesting practical history. The first clinical uses of aspiration cytology evolved from Scandinavia in the 1950s [1]. Martin and Ellis utilized this technique in 1930 to diagnose a variety of masses at Memorial Hospital in New York [2]. Stewart then reported 2,500 tumors in 1933 [3]. Subsequently, other European publications began to emphasize the utility of this method to more accurately characterize thyroid nodules [4–7]. How did the interest in cytology polarize to Scandinavia in those early years? At that time, pathologists in the United States were reluctant to accept this technique due to various reasons.

Keywords

Thyroid Nodule Papillary Carcinoma Fine Needle Aspiration Cytology Follicular Cell Multinodular Goiter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

20-Fine needle aspiration of solid component of complex nodu (8,982 KB)

88-FNA of mass, long axis approach (3,382 KB)

89-FNA short axis technique (1,115 KB)

90-Cyst with solid projection. FNA in short axis can targe(1,108 KB)

91-Cyst with mural component. FNA utilizing short axis app (1,084 KB)

92-Recurrent Hurthle cell carcinoma of thyroid bed. Note pr (56,865 KB)

189637_1_En_9_MOESM7_ESM.jpg (109 kb)

93-Thyroid lymphoma, transverse view (53 KB)

189637_1_En_9_MOESM8_ESM.jpg (141 kb)

94-thyroid lymphoma, sagittal view (68 KB)

189637_1_En_9_MOESM9_ESM.jpg (154 kb)

95-Measurements in advance of core biopsy. Note 2.44 cm of (73 KB)

96-Core biopsy after previous measurements. Note needle en (48,153 KB)

References

  1. 1.
    Soderstrom N. Puncture of goiters for aspiration biopsy. A preliminary report. Acta Med Scand. 1952;144:235–44.Google Scholar
  2. 2.
    Martin HE, Ellis B. Biopsy diagnosis by needle puncture and aspiration. Ann Surg. 1930;62:169–81.CrossRefGoogle Scholar
  3. 3.
    Stewart FW. The diagnosis of tumors by aspiration. Am J Pathol. 1933;9:801–13.PubMedGoogle Scholar
  4. 4.
    Einhorn J, Franzen S. Thin needle biopsy in the diagnosis of thyroid diseases. Acta Radiol. 1962;90:1619–25.Google Scholar
  5. 5.
    Lowhagen T, Zajicek J. In: Weid GL, editor. Thyroid in aspiration biopsy cytology. Part I. Cytology of supradiaphragmatic organs in monographs in clinical cytology, vol 4. Basel: S.Karger; 1974.Google Scholar
  6. 6.
    Lowhagen T, Granberg P, Lundell G, et al. Aspiration biopsy cytology (ABC) on nodules of the thyroid gland suspected to be malignant. Surg Clin North Am. 1979;59:3–18.PubMedGoogle Scholar
  7. 7.
    Akerman M, Tennvall J, Bjorklund J, et al. Sensitivity and specificity of fine needle aspiration cytology in the diagnosis of tumours of the thyroid gland. Acta Cytol. 1985;29:850–5.PubMedGoogle Scholar
  8. 8.
    Crockford PM, Bain GO. Fine needle aspiration biopsy of the thyroid. Can Med Assoc. 1974;110:1029–32.Google Scholar
  9. 9.
    Crile Jr G, Hawk Jr WA. Aspiration biopsy of thyroid nodules. Surg Gyn Obst. 1973;136:241–5.PubMedGoogle Scholar
  10. 10.
    Wang CA, Vickery Jr AL, Maloof F. Needle biopsy of the thyroid. Surg Gyn Obst. 1976;143:365–8.PubMedGoogle Scholar
  11. 11.
    Miller JM, Hamburger JI, Kini SR. Diagnosis of ­thyroid nodules by fine needle aspiration and needle biopsy. JAMA. 1979;241:481–6.PubMedCrossRefGoogle Scholar
  12. 12.
    Ashcraft MW, Van Herle AJ. Management of thyroid nodules II. Scanning techniques, thyroid suppression therapy, and fine needle aspiration. Head Neck Surg. 1981;3:297.PubMedCrossRefGoogle Scholar
  13. 13.
    Sudha R, Kini SR. Thyroid cytopathology. Philadelphia: Lippincott Williams and Wilkins; 2008. pp. 1, 2, 21–26.Google Scholar
  14. 14.
    Miller JM, Hamburger JI, Kini SR. The impact of needle biopsy on the preoperative diagnosis of thyroid nodules. Henry Ford Hosp Med J. 1980;28:145.PubMedGoogle Scholar
  15. 15.
    Randolph GW. Surgery of the thyroid and parathyroid glands. Philadelphia: Saunders; 2003. p. 139–40.Google Scholar
  16. 16.
    American Thyroid Association. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated ­thyroid cancer. Thyroid. 2009;19(11):8–9.Google Scholar
  17. 17.
    Danese D, Sciacchitano S, Farsetti A, Andreoli M, Pontecorvi A. Diagnostic accuracy of conventional versus sonography-guided fine-needle aspiration biopsy of thyroid nodules. Thyroid. 1998;8:15–21.PubMedCrossRefGoogle Scholar
  18. 18.
    Carmeci C, Jeffrey RB, McDougall IR, Nowels KW, Weigel RJ. Ultrasound-guided fine-needle aspiration biopsy of thyroid masses. Thyroid. 1998;8:283–9.PubMedCrossRefGoogle Scholar
  19. 19.
    Bonavita JA, Mayo J, Babb J, Bennett G, Oweity T, Macari M, et al. Pattern recognition of benign nodules at ultrasound of the thyroid: which nodules can be left alone? Am J Roentgenol. 2009;193:207–13.CrossRefGoogle Scholar
  20. 20.
    Moon WJ, Kwag HJ, Na DG. Are there any specific ultrasound findings of nodular hyperplasia (“leave me alone” lesion) to differentiate it from follicular adenoma? Acta Radiol. 2009;50:383–8.PubMedCrossRefGoogle Scholar
  21. 21.
    Santos JEC, Leiman G. Nonaspiration fine needle cytology: application of a new technique to nodular thyroid disease. Acta Cytol. 1988;32:353–6.PubMedGoogle Scholar
  22. 22.
    Mair S, Dunbar F, Becker PJ, et al. Fine needle cytology: is aspiration suction necessary? A study of 100 masses in various sites. Acta Cytol. 1989;33:809–13.PubMedGoogle Scholar
  23. 23.
    Lowhagen T, Williams JS, Lundell G, et al. Aspiration biopsy cytology in diagnosis of cancer. World J Surg. 1981;5:61–73.PubMedCrossRefGoogle Scholar
  24. 24.
    Kini SR, Miller JM, Hamburger JI, et al. Cytopathology of follicular lesions of the thyroid gland. Diagn Cytopathol. 1985;1:123–32.PubMedCrossRefGoogle Scholar
  25. 25.
    Goellner JR, Gharib H, Grant CS, et al. Fine needle aspiration cytology of the thyroid 1980–86. Acta Cytol. 1987;31:587–90.PubMedGoogle Scholar
  26. 26.
    Caruso D, Mazzaferri EL. Fine needle aspiration biopsy in the management of thyroid nodules. Endocrinologist. 1991;1:194–202.CrossRefGoogle Scholar
  27. 27.
    Alexander EK, Heering JP, Benson CB, Frates MC, Doubilet PM, Cibas ES, et al. Assessment of non-diagnostic ultrasound-guided fine needle aspiration of thyroid nodules. J Clin Endocrinol Metab. 2002;87:4924–7.PubMedCrossRefGoogle Scholar
  28. 28.
    Hegedus L. Clinical practice. The thyroid nodule. N Engl J Med. 2004;351:1674–771.CrossRefGoogle Scholar
  29. 29.
    Baloch ZW, LiVolsi VA, Asa SL, Rosai J, Merino MJ, Randolph G, et al. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference. Diagn Cytopathol. 2008;36:425–37.PubMedCrossRefGoogle Scholar
  30. 30.
    Carney JA et al. Hyalinizing trabecular tumors of the thyroid gland are almost all benign. Am J Surg Pathol. 2008;32:1877–89.PubMedCrossRefGoogle Scholar
  31. 31.
    Bartolazzi A, Orlandi F, Saggiorato E, et al. Italian Cancer Study Group (ITCSG) Galectin-3 expression analysis in the surgical selection of follicular thyroid nodules with indeterminate fine-needle aspiration cytology: a prospective multicenter study. Lancet Oncol. 2008;9:543–9.PubMedCrossRefGoogle Scholar
  32. 32.
    Nikiforov YE, Steward DL, Robinson-Smith TM, et al. Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules. J Clin Endocrinol Metab. 2009;94:2092–8.PubMedCrossRefGoogle Scholar
  33. 33.
    Franco C, Martinez V, Allamand JP, et al. Molecular markers in thyroid fine-needle aspiration biopsy: a prospective study. Appl Immunhistochem Mol Morphol. 2009;17:211–5.CrossRefGoogle Scholar
  34. 34.
    Marqusee E, Benson CB, Frates MC, et al. Usefulness of ultrasonography in the management of nodular thyroid disease. Ann Intern Med. 2000;1339:696–700.Google Scholar
  35. 35.
    Papini E, Guglielme R, Bianchini A, et al. Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features. J Clin Endocrinol Metab. 2002;87:1941–6.PubMedCrossRefGoogle Scholar
  36. 36.
    Frates MC, Benson CB, Doubilet PM, et al. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab. 2006;91:3411–7.PubMedCrossRefGoogle Scholar
  37. 37.
    Gharib H, Goellner JR. Fine needle aspiration biopsy of the thyroid: an appraisal. Ann Intern Med. 1993;118:282–9.PubMedGoogle Scholar
  38. 38.
    Hamburger JI. Extensive personal experience. Diagnosis of thyroid nodules by fine needle biopsy: use and abuse. J Clin Endocrinol Metab. 1994;79:335–9.PubMedCrossRefGoogle Scholar
  39. 39.
    Gharib H, Goellner JR, Johnson DA. Fine-needle aspiration cytology of the thyroid. A 12 year experience with 11,000 biopsies. Clin Lab Med. 1993;13:699–709.PubMedGoogle Scholar
  40. 40.
    Gharib H. Changing trends in thyroid practice: understanding nodular thyroid disease. Endocr Pract. 2004;10:31–9.PubMedGoogle Scholar
  41. 41.
    Yuen HY, Wong KT, Ahuja AT. Use of end-cutting needles in ultrasound-guided biopsy of neck lesions. In press.Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Division of Otolaryngology-Head and Neck SurgeryUniversity of Vermont School of Medicine, Fletcher Allen Health CareBurlingtonUSA

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