Coronavirus Receptors

  • Kathryn V. Holmes
  • Richard K. Williams
  • Charles B. Stephensen


One of the classic examples of host resistance to virus infection is mouse hepatitis virus (MHV), a murine coronavirus. In susceptible mouse strains, various strains of MHV cause enteric, respiratory, and neurological diseases. Bang and his colleagues showed that MHV could cause a fatal infection in one strain of mice but not in another. Peritoneal macrophages isolated from these mouse strains showed susceptibility or resistance to MHV corresponding to that of the intact animal [1]. This difference in host susceptibility was due to a single autosomal gene, hv-1, and the allele for resistance to the fatal disease was recessive [2].


Brush Border Membrane Infectious Bronchitis Virus Mouse Hepatitis Virus Intestinal Brush Border Membrane Feline Infectious Peritonitis Virus 
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Copyright information

© Springer-Verlag New York Inc. 1989

Authors and Affiliations

  • Kathryn V. Holmes
  • Richard K. Williams
  • Charles B. Stephensen

There are no affiliations available

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