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Proton Fourier Transform NMR as a Trace Analysis Tool; Optimization of Signal-To-Noise

  • F. H. A. Rummens
Chapter
Part of the Environmental Science Research book series (ESRH, volume 4)

Abstract

An experimental study has been made of all the factors which influence the Signal-to-Noise ratio in FT NMR. In particular the achievable Signal-to-Noise per time unit is discussed. A detection limi t of 1 ppm (1 ug) or a reasonable spectrum at 10 ppm (10 ug) is achievable in 1 hour of experimentation time. A further improvement by a factor of 10 in detection limit appears feasible, at the sacrifice of very long experimentation time but the major obstacle is provided by proton-carrying solvent impurities. In practical applications the same problem gives rise to the need for highly specific extraction and clean-up procedures. A general description of the Puls Fourier Transform technique is given and a general method for optimizing towards maximum Signal-to-Noise per-time-unit is evolved.

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References

  1. J.W. Cooper “An Introduction to Fourier Transform NMR and the Nicolet 1080 Data System.” Nicolet Instrument Corp. Madison (Wisc.) 1972.Google Scholar
  2. H. Hill, R. Freeman “Introduction to Fourier Transform NMR” Varian Associates Palo Alta (1970).Google Scholar
  3. R.R. Ernst Advances in Magnetic Resonance (Ed. J.S. Waugh) Vol. 2 Academic Press (1970).Google Scholar
  4. D.G. Gilles, D. Shaw Annual Reports on NMR Spectroscopy (Ed. E.F. Mooney) Vol 5A pp 560–630 Academic Press 1973.Google Scholar

Copyright information

© Springer Science+Business Media New York 1974

Authors and Affiliations

  • F. H. A. Rummens
    • 1
  1. 1.Department of ChemistryUniversity of SaskatchewanRegina (Sask.)Canada

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