Proton Fourier Transform NMR as a Trace Analysis Tool; Optimization of Signal-To-Noise
An experimental study has been made of all the factors which influence the Signal-to-Noise ratio in FT NMR. In particular the achievable Signal-to-Noise per time unit is discussed. A detection limi t of 1 ppm (1 ug) or a reasonable spectrum at 10 ppm (10 ug) is achievable in 1 hour of experimentation time. A further improvement by a factor of 10 in detection limit appears feasible, at the sacrifice of very long experimentation time but the major obstacle is provided by proton-carrying solvent impurities. In practical applications the same problem gives rise to the need for highly specific extraction and clean-up procedures. A general description of the Puls Fourier Transform technique is given and a general method for optimizing towards maximum Signal-to-Noise per-time-unit is evolved.
Unable to display preview. Download preview PDF.
- J.W. Cooper “An Introduction to Fourier Transform NMR and the Nicolet 1080 Data System.” Nicolet Instrument Corp. Madison (Wisc.) 1972.Google Scholar
- H. Hill, R. Freeman “Introduction to Fourier Transform NMR” Varian Associates Palo Alta (1970).Google Scholar
- R.R. Ernst Advances in Magnetic Resonance (Ed. J.S. Waugh) Vol. 2 Academic Press (1970).Google Scholar
- D.G. Gilles, D. Shaw Annual Reports on NMR Spectroscopy (Ed. E.F. Mooney) Vol 5A pp 560–630 Academic Press 1973.Google Scholar