Role of Lymphocytes in Graft-Versus-Host Disease and its Prevention
The most frequent complication to occur after the take of an incompatible bone marrow graft is graft-versus-host disease (GvHD) in any of its various forms. It is now commonly accepted that this disease is caused by an immunological reaction of T lymphocytes which have been transferred with the graft itself or by T lymphocytes which develop from grafted precursor cells. The GvH reaction is directed against the tissue antigens of the recipient leading to pathological changes in many organs: the skin, the intestinal tract and the liver being most frequently and severely affected. In general, GvHD develops only following transplantation of allogeneic or xenogeneic bone marrow, but a similar syndrome has been observed occasionally when syngeneic bone marrow is grafted under very special conditions. In all animal species studied so far, the symptomatology of GvDH proved to be very similar. Most of the information available today is derived from mice, rats, dogs and monkeys and of course from the human transplant patients.
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- 2.Mathé G, Bernard J, De Vries MJ, et al. Nouveaux essais de greffe de moëlle osseuse homologue après irradiation totale chez des enfants atteints de leucémie aiguë en rémission. Rev Hémat 1960; 15: 113–61.Google Scholar
- 6.Vriesendorp HM, Bijnen AB, Van Kessel ACM, Obertop H, Westbroek DL. Minor histocompatibility systems in dogs. In: Baum SJ, Ledney GD, eds. Experimental hematology today 1978. New York, Springer Verlag: 1978: 109–17.Google Scholar
- 9.Van Bekkum DW. Transfusion or transplantation? Isr J Med Sci 1965; 1: 870–82.Google Scholar
- 16.Löwenberg B, De Zeeuw MHC, Dicke KA, Van Bekkum DW. Nature of the graft-versus-host reactivity of fetal liver cell transplants in mice. J Nat Cancer Inst 1977;58:959–66.Google Scholar
- 20.Coifman RE, Meuwissen HJ. Elimination of graft-versus-host competent lymphocytes from transfusable blood components by radiation. Fed Proc 1971; 30: 456.Google Scholar