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Immune Modulation Aspects of Blood Transfusion in Transplantation Practice

  • G. G. Persijn
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 10)

Abstract

There are many ways to alter the immune response of a recipient to an organ graft. Sofar, the most successful approaches in renal transplantation are matching of donors and recipients for the HLA-A, -B and -DR antigens, the use of immunosuppressive drugs and pretransplant blood transfusions. The latter factor has received considerable attention since Opelz and Terasaki in 1973 (1) reported that kidney graft recipients who never had received blood transfusions prior to transplantation had a very poor kidney graft survival. Since then, many different protocols have been designed for experimental and clinical studies to investigate the role of pretransplant blood transfusions in renal transplantation.

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© Springer Science+Business Media Dordrecht 1984

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  • G. G. Persijn

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