Dr. Glassman, with regard to the utility of the cryopreserved platelets, I think the technique that you have described is a feasible one. With regard to the clinical application, I wonder what the use of cryopreserved platelets actually will be. The reason for this is that I can think of two situations where platelets will be needed at a very frequent rate, that is in support of patients undergoing bone-marrow transplantation, and in support of patients undergoing intensive chemotherapy for diseases which are mainly acute leukemias. With regard to the bone-marrow transplantation, there really would be no need for cryopreserved platelets, for as long as an HLA identical sibling is available fresh HLA matched platelets can be used.
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