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Autologous Transplanation of Blood Derived Hemopoietic Stem Cells

  • M. Körbling
  • Th. M. Fliedner
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 10)

Abstract

The existence of circulating hemopoietic stem cells in the peripheral blood has been demonstrated by in vivo studies using preclinical animal models and by in vitro experiments. A bulk of data obtained in the canine model suggests that it would be possible to use stem cells collected from the peripheral blood of man for the purposes of hemopoietic reconstitution following an intensive cytoreductive pulse of pre-transplant therapy if adequate numbers of those cells could be harvested. The usual way of collecting a large amount of blood-derived hemopoietic stem cells is that of hemapheresis using a continuous flow blood cell separator.

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References

  1. 1.
    Fliedner TM. Advances in hemopoietic stem cell research: their significance for clinical hematology. XII Congress of the International Society of Hematology, Paris, July 1978.Google Scholar
  2. 2.
    Fliedner TM, Calvo W, Korbling M, Nothdurft W, Pflieger H, Ross W. Collection, storage and transfusion of blood stem cells for the treatment of hemopoietic failure. Blood Cells 1979; 5: 313–28.PubMedGoogle Scholar
  3. 3.
    Körbling M, Fliedner TM, Calvo W, et al. Albumin density gradient purification of canine hemopoietic blood stem cells (HBSC): Long-term allogeneic engraftment without GVH-reaction. Exp Hematol 1979; 7: 277–88.PubMedGoogle Scholar
  4. 4.
    Körbling M, Fliedner TM, Pflieger H. Collection of large quantities of granulocyte/macrophage progenitor cells (CFUc) in man by means of con-tinuous-flow leukapheresis. Scand J Haematol 1980; 24: 22–8.PubMedCrossRefGoogle Scholar
  5. 5.
    Ross WM, Körbling M, Nothdurft W, Fliedner TM. The role of dextransulfate in increasing the CFU-C concentration in dog blood. Proc Soc Exp Biol Med 1978; 157: 301–5.PubMedCrossRefGoogle Scholar
  6. 6.
    Korbling M, Fliedner TM, Rüber E, Pflieger H. Description of a closed plastic-bag system for the collection and cryopreservation of leukapheresis-derived blood mononuclear leukocytes and CFUc from human donors. Transfusion 1980; 20: 293–300.PubMedCrossRefGoogle Scholar
  7. 7.
    Goldman JM, Catovsky D, Goolden AWG, Johnson SA, Galton DAG. Buffy coat autografts for patients with chronic granulocytic leukemia in transformation. Blut 1981; 42: 149–55.PubMedCrossRefGoogle Scholar
  8. 8.
    Körbling M, Burke P, Braine H, Elfenbein G, Santos G, Kaizer H. Successful engraftment of blood derived normal hemopoietic stem cells in chronic myelogenous leukemia. Exp Hematol 1981; 9: 684–90.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1984

Authors and Affiliations

  • M. Körbling
  • Th. M. Fliedner

There are no affiliations available

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