Aspects of Grafting and Rejection with Special Reference to the Transplantation of Lymphocytes
An allograft involves the transfer of one part of an organism to a genetically dissimilar individual of the same species. The term embraces three situations which are radically different in their physical and biological characteristics. First, a whole organ may be grafted with its blood supply intact by anastomosing its blood vessels to suitable blood vessels in the recipient. Examples are skin grafts placed on suitably prepared beds in the recipient and thymus grafts placed under the kidney capsule where they soon acquire a new blood supply. Third, dissociated cells may be grafted by injecting them directly into the bloodstream. Obviously this is most appropriate when the donor cells are normally present in the bloodstream or are able to leave the bloodstream easily to enter their natural environment as is the case with grafts of lymphocytes or bone marrow.
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