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New Developments in Kidney Preservation

  • G. Kootstra
  • B. G. Rijkmans
  • W. A. Buurman
  • Th. J. M. Ruers
  • J. P. van Hooff
Chapter
Part of the Developments in Hematology and Immunology book series (DIHI, volume 10)

Abstract

When one overlooks the history of kidney preservation, it is impressive what has been reached in a period of just thirty years, assuming that the real kidney preservation started with the introduction of hypothermia. In 1952 Lefebre and Nizet (1) introduced cold storage aiming at a reduction of cellular metabolism. They cooled the kidney by immersing it in a cold solution (surface cooling). Flushing of the vascular tree of the kidney with a cold solution was introduced by Pegg and Calne (2) in 1963 and a preservation period of 24 hours in the dog model was reached. In the USA Humphries (3) worked on machine preservation and reached 48 hours in 1964. In 1967 Belzer (4) introduced cryoprecipitated plasma as perfusate in a modified machine constructed by him and his co-workers. Since their work cadaveric kidney transplantation is performed on an elective basis. Two years later, Collins (5) introduced the hyperosmolar solution for simple cold storage and it is this method, slightly modified as Eurocollins, that has reached overwhelming popularity in Europe. In the USA machine preservation has been the method of choice since Belzer’s publication, though since the retrospective study of Opelz and Terasaki (6), published in 1978, stating that no advantage of machine preservation over cold storage could be established, the scene in the USA is changing towards cold storage. At the end of this bird’s-eye survey of the development of preservation — far too short and not given credit to all the work performed — the question can be posed: How good then is this cold storage?

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References

  1. 1.
    Lefebre L, Nizet E. Shunt vasculaire dans les reins de chiens perfusés et conservés a basse temperature. Arch Int Pharmacol 1952; 92: 119–27.Google Scholar
  2. 2.
    Pegg DE, Calne RY, Pryse-Davies J, Leigh-Brown F. Canine renal preservation using surface and perfusion cooling techniques. Ann NY Acad Sci 1964; 120: 506–23.PubMedGoogle Scholar
  3. 3.
    Humphries AL, Russel R, Gregory J, Carter RH, Moretz WH. Hypothermic perfusion of the canine kidney for 48 hours followed by reimplantation. Am Surg 1964; 30: 748–52.PubMedGoogle Scholar
  4. 4.
    Belzer FO, Ashby BS, Dunphy JE, 24-hour and 72-hour preservation of canine kidneys. Lancet 1969;ii:536–9.Google Scholar
  5. 5.
    Collins GM, Bravo-Shugarmon M, Terasaki PI. Kidney preservation for transplantation. Lancet 1969;ii:1219–22.CrossRefGoogle Scholar
  6. 6.
    Opelz G, Terasaki PI. Advantage of cold storage over machine perfusion for transplantation of cadaver kidneys. Transplantation 1982; 33: 64–8.PubMedCrossRefGoogle Scholar
  7. 7.
    Squifflet JP, Pirson Y, Gianello P, Van Caugh P, Alexandre GPJ. Safe preservation of human renal cadaver transplants by Eurocollins solution up to 50 hours. Transplant Proc 1981; XIII: 693–6.Google Scholar
  8. 8.
    Abouna GM, Kumar AS, White AG, et al. Experience with imported human cadaveric kidneys having unusual problems and transplanted after 30–60 hours of preservation. Transplant Proc 1984; XVI:61–3.Google Scholar
  9. 9.
    Belzer FO. Transplant Proc 1984; XVI:161–3.Google Scholar
  10. 10.
    Fisher JH, Czerniak H, Hauer U, Isselhard W. A new simple method for optimal storage of ischemically damaged kidneys. Transplantation 1978; 25: 362–4.Google Scholar
  11. 11.
    Ross H, Escott ML. Gaseous oxygen perfusion of the renal vessels as an adjunct in kidney preservation. Transplantation 1979; 28: 362–4.PubMedCrossRefGoogle Scholar
  12. 12.
    Rolles K. Personal communication.Google Scholar
  13. 13.
    Cohen GL, Johnson RWG. Perfusate buffering for 8-day canine kidney storage. Proc Eur Soc Art Org 1980; VII:235–9.Google Scholar
  14. 14.
    Woods JE. Successful three-to-seven-day preservation of canine kidneys. Arch Surg 1971; 102: 614–7.PubMedCrossRefGoogle Scholar
  15. 15.
    Liu WP, Humphries AL, Russell R, Stoddard LD, Garcia LA, Serkes KD. Three- and seven-day perfusion of dog kidneys with human plasma protein fraction IV-4. Surgical Forum 1973; 24: 316–8.PubMedGoogle Scholar
  16. 16.
    Cohen GL, Ballardie FW, Mainwaring A, Johnson RWG. Lysosomal enzyme release during successful 5-, 7- and 8-day canine kidney storage. In: Pegg DE, Jacobsen IA, Halasz NA, eds. Organ preservation: Basic and applied aspects. Lancaster-Boston-The Hague: MTP Press Ltd, 1982: 249–53.CrossRefGoogle Scholar
  17. 17.
    Ozaki A, Fukao K, Sano M, Okamura T, Iwasaki Y. Five-day preservation of canine kidneys using a preservation machine. In: Pegg DE, Jacobson IA, Halasz NA, eds. Organ preservation: Basic and applied aspects. Lancaster-Boston-The Hague: MTP Press Ltd, 1982: 245–49.CrossRefGoogle Scholar
  18. 18.
    Rijkmans BG, Van der Wijk J, Donker AJM, Slooff MJH, Kootstra G. Functional studies in 6 days successful preserved canine kidneys. J Urol 1982; 127: 163–5.PubMedGoogle Scholar
  19. 19.
    Toledo-Pereyra LH, Condie RM, Malmberg R, Simmons RL, Najarian JS. A fibrinogen-free plasma perfusate for preservation of kidneys for one hundred and twenty hours. Surg Gyn Obst 1974; 138: 901–6.PubMedGoogle Scholar
  20. 20.
    Van der Wijk J, Sloof MJH, Rijkmans BG, Kootstra G. Successful 96 and 144 hour experimental kidney preservation: A combination of standard machine preservation and newly developed normothermic ex-vivo perfusion. Cryobiology 1980; 17: 473–7.PubMedCrossRefGoogle Scholar
  21. 21.
    Kootstra G, Van der Wijk J, Rijkmans BG. A new device towards intermediate term kidney preservation. An experimental study. Scand J Urol Nephrol (Suppl) 1980; 54: 86–9.Google Scholar
  22. 22.
    Van der Wijk J, Rijkmans BG, Kootstra G. Six day kidney preservation in a canine model. Influence of a 1 to 4 hr ex-vivo perfusion interval. Transplantation 1983; 35: 408–11.PubMedCrossRefGoogle Scholar
  23. 23.
    Rijkmans BG, Kootstra G, Van der Wijk J, Nizet A. Intermediate ex vivo and in vitro perfusion to prolong hypothermic kidney preservation up to six days. In: Pegg DE, Jacobson IA, Halasz NA, eds. Organ preservation: Basic and applied aspects. Lancaster-Boston-The Hague: MTP Press Ltd, 1982: 267–72.CrossRefGoogle Scholar
  24. 24.
    Spector D, Limas C, Frost JL, et al. Perfusion nephropathy in human transplants. N Engl J Med 1976; 295: 1217–21.PubMedCrossRefGoogle Scholar
  25. 25.
    Hill GS, Light JA, Perloff LJ. Perfusion-related injury in renal transplantation. Surgery 1976; 79: 440–7.PubMedGoogle Scholar
  26. 26.
    Cerra FB, Raza S, Andres GA, Siegel JH. The endothelial damage of pulsatile renal preservation and its relationship to perfusion pressure and colloid osmotic pressure. Surgery 1977; 81: 534–41.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 1984

Authors and Affiliations

  • G. Kootstra
  • B. G. Rijkmans
  • W. A. Buurman
  • Th. J. M. Ruers
  • J. P. van Hooff

There are no affiliations available

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