Voltage Clamp Studies Of Calcium Channel Blockage in the Heart

  • R. S. Kass
  • M. C. Sanguinetti
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 39)


It is now recognized that calcium channels exist in a wide variety of cells and participate in many aspects of cellular function (for review, see refs. 1 and 2). In the heart, voltage-dependent calcium ion influx underlies spontaneous activity and impulse conduction in the sinoatrial and atrioventricular nodes, maintains the plateau phase of ventricular action potentials, and is closely associated with activation of contraction (3–6). Thus, it is not surprising that compounds which block calcium channels are of considerable interest to cellular electrophysiologists and, in particular, to those interested in the electrophysiology of the heart.


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© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • R. S. Kass
  • M. C. Sanguinetti

There are no affiliations available

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