Advertisement

Voltage Clamp Studies Of Calcium Channel Blockage in the Heart

  • R. S. Kass
  • M. C. Sanguinetti
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 39)

Abstract

It is now recognized that calcium channels exist in a wide variety of cells and participate in many aspects of cellular function (for review, see refs. 1 and 2). In the heart, voltage-dependent calcium ion influx underlies spontaneous activity and impulse conduction in the sinoatrial and atrioventricular nodes, maintains the plateau phase of ventricular action potentials, and is closely associated with activation of contraction (3–6). Thus, it is not surprising that compounds which block calcium channels are of considerable interest to cellular electrophysiologists and, in particular, to those interested in the electrophysiology of the heart.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hagiwara S, Byerly L: Calcium channel. Ann Rev Neurosci (4): 69–125, 1981.PubMedCrossRefGoogle Scholar
  2. 2.
    Tsien RW: 1983. Calcium channels in excitable cell membranes. Ann Rev Physiol (45): 341–358, 1983.CrossRefGoogle Scholar
  3. 3.
    Kass RS, Scheuer T: Slow inactivation of calcium channels in the cardiac Purkinje fiber. J Molec Cell Cardiol (14): 615–618, 1982.CrossRefGoogle Scholar
  4. 4.
    Reuter H: 1979. Properties of two inward membrane currents in the heart. Ann Rev Physiol (41): 413–424, 1979.Google Scholar
  5. 5.
    Reuter H: Divalent cations as charge carriers in excitable membranes. Prog Biophys Mol Biol (26): 1–43, 1973.PubMedCrossRefGoogle Scholar
  6. 6.
    Fozzard HA: Heart: Excitation-contraction coupling. Ann Rev Physiol (39): 201–220, 1977.CrossRefGoogle Scholar
  7. 7.
    Flaim SF, Zelis R: Calcium Blockers, Mechanisms of Action and Clinial Implications. Urban and Schwarzenburg, Baltimore, Munich, 1982, p. 303.Google Scholar
  8. 8.
    Singh BN, Nademanee K, Baky SH: Calcium antagonists. Clinical use in the treatment of arrhythmias. Drugs (25): 125–153, 1983.PubMedCrossRefGoogle Scholar
  9. 9.
    Schwartz A, Taira N: Symposium on calcium channel blocking drugs: A novel intervention for the treatment of cardiac disease. Circ Res (52) (Part II, Suppl.): 1983, 181 pp.Google Scholar
  10. 10.
    Janis RA, Triggle DJ: New Developments in Ca2+ channel antagonists. J Med Chem (26): 775–785, 1983.PubMedCrossRefGoogle Scholar
  11. 11.
    Kass RS, Scheuer T, Malloy KJ: Block of outward current in cardiac Purkinje fibers by injection of quaternary ammonium ions. J Gen Physiol (79): 1041–1063, 1982.PubMedCentralPubMedCrossRefGoogle Scholar
  12. 12.
    Kass RS, Siegelbaum SA, Tsien RW: Three-micro-electrode voltage clamp experiments in calf cardiac Purkinje fibers: Is slow inward current adequately measured? J Physiol (290): 201–225, 1979.PubMedCentralPubMedGoogle Scholar
  13. 13.
    Kass RS: Nisoldipine: a new, more selective calcium current blocker in cardiac Purkinje fibers. J Pharm Exp Ther (223): 446–456, 1982.Google Scholar
  14. 14.
    Kass RS: Measurement and block of voltage-dependent calcium current in the heart. In: Merrill, GF, Weiss HR (eds) Ca2+ entry blockers, adenosine, and neurohumors. Urban and Schwarzenberg, Baltimore, 1983.Google Scholar
  15. 15.
    Bayer R, Hennekes R, Kaufman R, Mannhold R: Inotropic and electrophysiological actions of verapamil and D600 in mammalian myocardium. I. Pattern of inotropic effects of the racemic compounds. Naunyn-Schmiedeberg’s Arch Pharmacol (290): 49–68, 1975.PubMedCrossRefGoogle Scholar
  16. 16.
    Bayer R, Kaufmann R, Mannhold R, Rodenkirchen R: The action of specific Ca antagonists on cardiac electrical activity. Prog Pharmacol (5): 53–85, 1982.Google Scholar
  17. 17.
    Hille B: Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol (69): 497–515, 1977.PubMedCrossRefGoogle Scholar
  18. 18.
    Hondeghem LM, Katzung BG: Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta (472): 373–398, 1977.PubMedCrossRefGoogle Scholar
  19. 19.
    Bean BP, Cohen CJ, Tsien RW: Lidocaine block of cardiac sodium channels. J Gen Physiol (81): 613–642, 1983.PubMedCentralPubMedCrossRefGoogle Scholar
  20. 20.
    Rodenkirchen R, Bayer R, Mannhold R: Specific and nonspecific Ca antagonists. A structure-activity analysis of cardiodepressive drugs. Prog. Pharmacol (5): 9–23, 1982.Google Scholar
  21. 21.
    Marban E, Tsien RW: Effects of nystatin-mediated intracellular ion substitution on membrane curents in calf Purkinje fibres. J Physiol 329: 569–587, 1982.PubMedCentralPubMedGoogle Scholar
  22. 22.
    Colatsky TJ: Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres. J Physiol (305): 215–234, 1980.PubMedCentralPubMedGoogle Scholar
  23. 23.
    Kass RS, Wiegers SE: Ionic basis of concentration-related effects of noradrenline on the action potential of cardiac Purkinje fibres. J Physiol (322): 541–558, 1982.PubMedCentralPubMedGoogle Scholar
  24. 24.
    Trautwein W, Pelzer D, McDonald TF: Interval-and voltage-dependent effects of the calcium channel- blocking agents D600 and AQA 39 on mammalian ventricular muscle. Circ Res 52 (Part II, Suppl.): 160–168, 1983.Google Scholar
  25. 25.
    BayerR, Ehara T: Comparative studies on calcium antagonists. Prog Pharmacol. 2: 31–37, 1978Google Scholar
  26. 26.
    McDonald TF, Pelzer D, Trautwein W: On the mechanism of slow calcium channel block in heart. Pflugers Arch (385): 175–179, 1980PubMedCrossRefGoogle Scholar
  27. 27.
    Pelzer D, Trautwein W, McDonald TF: Calcium channel block in mammalian ventricular muscle treated with organic channel inhibitors. Pflugers Arch (394): 97–105, 1982.PubMedCrossRefGoogle Scholar
  28. 28.
    Lee KS, Tsien RW: Mechanism of calcium channel block by verapamil, D600, diltiazem, and nitrendipine in single dialyzed heart cells. Nature (302): 790–794, 1983PubMedCrossRefGoogle Scholar
  29. 29.
    Kanaya S, Arlock P, Katzung B, Hondeghem LM: Diltiazem and verapamil preferentially block inactivated cardiac calcium channels. J Molec Cell Cardiol (15): 145–148, 1983CrossRefGoogle Scholar
  30. 30.
    Kass RS, Sanguinetti MC: Calcium channel inactivation in the cardiac Purkinjie fibre: evidence for voltage- and calcium-mediated mechanisms. 1983. In Preparation.Google Scholar
  31. 31.
    Rowland E, McKenna WJ, Gulker H, Krikler DM: The comparative effects of diltiazem and verapamil on atrioventricular conduction and atrioventricular reentry tachycardia. Circ Res (52) (Part II, Suppl.): 1163–I168, 1983.PubMedGoogle Scholar
  32. 32.
    Rowland E, Curry P, Fox K, Krikler DM: Relation between atrioventricular pathways and ventricular response during atrial fibrillation and flutter. Br Heart J (45): 83–87, 1981.PubMedCentralPubMedCrossRefGoogle Scholar
  33. 33.
    DePonti C, Mauri F, Ciliberto GR, Caru B: Comparative effects of nifedipine, verapamil, isosorbide dinitrate and propranolol on exercise induced angina pectoris. Eur J Cardiol (10): 47–58, 1979.Google Scholar
  34. 34.
    Klein W, Brandt D, Vrecko K, Harringer M: Role of calcium antagonists in the treatment of essential hypertension. Circ Res 52 (Part II, Suppl.): 1174–1181, 1983.Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • R. S. Kass
  • M. C. Sanguinetti

There are no affiliations available

Personalised recommendations