Effects of Inhibitors of Arachidonic Acid Metabolism and Calcium Entry on Hypoxic Contractions of the Isolated Canine Coronary Artery

  • Thomas J. Rimele
  • Paul M. Vanhoutte
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 39)


Constriction of large coronary arteries (coronary vasospasm) leads to an acute decrease in coronary blood flow. Although many factors [e.g. aggregating platelets (1), catecholamines (2–5), 5-hydroxytryptamine (3,4), prostaglandins (1,5-8), potassium ions (1-3,9), ergonovine maleate (3), hydroperoxides of arachidonic acid and leukotrienes (6–12), hypoxia and ischemia (3,4,13,14)] are able to cause contraction of coronary vascular smooth muscle, the exact etiology of coronary vasospasm is unknown.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • Thomas J. Rimele
  • Paul M. Vanhoutte

There are no affiliations available

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