The Effect of Verapamil on Lanthanum (La3+) Binding in the Isolated Rabbit Heart
Knowledge of the role of calcium in contractility dates back to the time of Ringer (1). He showed in cardiac muscle that extracelluar calcium was essential for the development of contractile force. Subsequent work has reinforced the notion that extracelluar calcium is essential for maintenance of contraction in cardiac muscle (2). The dependence of contraction upon extracellular calcium has been expanded to smooth muscle as well (3). Furthermore, the interaction of calcium with the sarcolemma (binding, channel passage, ionic exchange mechanisms, etc.) has been shown to be an important modifier of the effect of calcium upon contraction in both cardiac and smooth muscle (3, 4, 5, 6, 7). Those interactions, in particular calcium binding to the cardiac sarcolemma and various other cell membranes, are the subject of this work.
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