Effect of Nifedipine on Rat Papillary Muscle and Perfused Heart

  • P. Braveny
  • J. S. Juggi
  • G. Telahoun
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 39)


Calcium antagonists, a heterogenous group of slow transmembrane current inhibitors, differ in their relative effect on smooth vascular muscle (relaxation), working myocardium (negative inotropic effect) and conductive tissue of the heart (negative dromotropic effect). The latter predominates after verapamil, a common antiarrhythmic drug. Nifedipine has been successfully used in the treatment of chronic ischemic heart disease because of its prevailing vasodilatatory effect (Braunwald, 1982). In addition, nifedipine appears to be a useful protective constituent of cardioplegic solutions employed during cold ischemic arrest in cardiac surgery (Clark et al, 1979). It is thus more than of theoretical interest to know the dependence of the effect of nifedipine on frequency and temperature, two variables which are deeply involved in the calcium turnover of the heart muscle cell.


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Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • P. Braveny
    • 1
  • J. S. Juggi
    • 1
  • G. Telahoun
    • 1
  1. 1.Department of Physiology, Faculty of MedicineKuwait UniversityKuwait

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