Advertisement

Effect of Nifedipine on Rat Papillary Muscle and Perfused Heart

  • P. Braveny
  • J. S. Juggi
  • G. Telahoun
Chapter
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 39)

Abstract

Calcium antagonists, a heterogenous group of slow transmembrane current inhibitors, differ in their relative effect on smooth vascular muscle (relaxation), working myocardium (negative inotropic effect) and conductive tissue of the heart (negative dromotropic effect). The latter predominates after verapamil, a common antiarrhythmic drug. Nifedipine has been successfully used in the treatment of chronic ischemic heart disease because of its prevailing vasodilatatory effect (Braunwald, 1982). In addition, nifedipine appears to be a useful protective constituent of cardioplegic solutions employed during cold ischemic arrest in cardiac surgery (Clark et al, 1979). It is thus more than of theoretical interest to know the dependence of the effect of nifedipine on frequency and temperature, two variables which are deeply involved in the calcium turnover of the heart muscle cell.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Bayer, R., Rodenkirchen, R., Kaufmann, R., Lee, J.H., Hennekes, R:.The effects of nifedipine on contraction and monophasic action potential of isolated cat myocardium. Naunyn Schmiedeberg’s Arch. Pharmacol. 30: 29–37 (1977).Google Scholar
  2. Blinks, J.R., Koch-Weser, J.: Physical factors in the analysis of the actions of drugs on myocardial contractility. Pharm.Rev. 15: 531–599 (1963).PubMedGoogle Scholar
  3. Braunwald, E .: Mechanism of action of calcium-channel- blocking agents. New Engl.J.Med. 307, 1918–1627 (1982).Google Scholar
  4. Braveny, P., Juggi, J.S., Yousof, A,M., Telahoun, G.: Temperature and frequency dependence of the negative inotropic effect of nifedipine. J.Mo1.Cell.Cardiol. 15: (suppl.1) Abstr. 380 (1983)Google Scholar
  5. Clark, R.E., Christlieb, I.Y., Henry, P.D.,Fischer, A.E., Nora, J.D., Williamson, J.R., Sobel, B.E.: Nifedipine: A myocardial protective agent. Amer.J.Cardiol. 44: 825–831(1979).PubMedCrossRefGoogle Scholar
  6. Ehara, T., Kaufmann, R.: The voltage and time dependent effects of (-) verapamil on the slow inward current in isolated cat ventricular myocardium. J. Pharma. Exp. Ther. 207: 49–55 (1978).Google Scholar
  7. Goto, M., Tsuda, Y., Yatani, A., Saito, M.: Effects of low temperature on the membrane currents and tension components of bullfrog atrial muscles.Jap.J.Physiol. 28: 211–224 (1978).CrossRefGoogle Scholar
  8. Kass, R.S., Tsien, R.W.: Multiple effects of calcium antagonists on pleateau currents in cardiac Purkinje fibres. Gen. Physiol. 66: 169–192 (1975).CrossRefGoogle Scholar
  9. Kruta, V.: Sur l’activite rythmique du muscle cardiaque. II variations en fonction de la temperature. Arch. Int. Physiol. 47: 35–62 (1938).Google Scholar
  10. Molyvdas, P.A., Sperelakis,N.: Comparison of the effects of several calcium antagonistic drugs (slow channel blockers) on the electrical and mechanical activities of guinea pig papillary muscle. J. Cardiovasc. Pharm. 5: 162–169 (1983).CrossRefGoogle Scholar
  11. Morgan, V.P., Wier,W.G., Hess,P., Blinks,J.R.: Influence of Ca++-channel blocking agents on calcium transients and tension development in isolated mammalian heart muscle. Circ.Res. 52(suppl. I ): 47–52 (1983).Google Scholar
  12. Shattock, M.J., Hearse,D.J.: Temperature dependence of the force-frequency relationship. J. Mol. cell. Cardiol. 15 (suppl 1) Abstr. 223 (1983)Google Scholar
  13. Spieckermann, P.G., Piper, H.M., Hutter, J.F.: Temperature dependent effectiveness of Ca++ antagonizing drugs. J. Mol. cell. Cardiol.(suppl 1) Abstr. 224(1983)Google Scholar
  14. Yamamoto, F., Hearse, D.J.: Temperature dependency in the efficacy of calcium antagonists. J. Mol. cell. Cardiol. 15 (suppl I) Abstr. 222 (1983).Google Scholar

Copyright information

© Martinus Nijhoff Publishing, Boston 1984

Authors and Affiliations

  • P. Braveny
    • 1
  • J. S. Juggi
    • 1
  • G. Telahoun
    • 1
  1. 1.Department of Physiology, Faculty of MedicineKuwait UniversityKuwait

Personalised recommendations