Relaxin pp 315-322 | Cite as

Effect of a Purified Porcine Relaxin Upon Glycogen and Protein in the Rat Uterus

  • Edward H. Frieden
  • Peter VasilenkoIII
  • Walter C. Adams
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 143)


The recent isolation (Sherwood and O’Byrne, 1974; Frieden et al., 1980) and characterization of porcine relaxin as a two-chain polypeptide bearing a distinct structural similarity to insulin (Schwabe and McDonald, 1977; James et al., 1977) has revived interest in an earlier report (Steinetz et al., 1950) that relaxin can exert glycogenic and protein anabolic effects in ovariectomized, estrogen- treated rats. Since the relaxins used in these early experiments were of relatively low specific activity (10–150 GPU/mg), we have examined the metabolic effects of purified, electrophoretically homogenous porcine relaxin as well as NIH-relaxin.


Glycogen Content Uterine Weight Estradiol Benzoate Relaxin Receptor Blood Glucose Conc 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Edward H. Frieden
    • 1
  • Peter VasilenkoIII
    • 1
  • Walter C. Adams
    • 1
  1. 1.Departments of Chemistry and Biological SciencesKent State UniversityKentUSA

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