Relaxin pp 273-282 | Cite as

Effect of Porcine Relaxin on Cyclic Nucleotide Levels and Spontaneous Contractions of the Rat Uterus

  • B. M. Sanborn
  • H. S. Kuo
  • N. W. Weisbrodt
  • O. D. Sherwood
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 143)


Relaxin has been known for some time to inhibit spontaneous uterine contractions in a number of species (Schwabe et al., 1978). Furthermore a number of studies have indicated that circulating factors in addition to steroid hormones regulate uterine contractility and responsiveness during pregnancy (Porter, 1972; Korenman et al., 1974; Porter and Downing, 1978). In the human, serum relaxin levels are elevated early in pregnancy, suggesting that this hormone may play a role in maintaining uterine quiescence during that period (Quagliarello et al., 1979).


Cyclic Nucleotide Adenylate Cyclase Activity Spontaneous Contraction Estradiol Benzoate Uterine Contractility 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • B. M. Sanborn
    • 1
  • H. S. Kuo
    • 1
  • N. W. Weisbrodt
    • 2
  • O. D. Sherwood
    • 3
  1. 1.Departments of Reproductive Medicine and BiologyThe University of Texas Medical School at HoustonHoustonUSA
  2. 2.Department of PhysiologyThe University of Texas Medical School at HoustonHoustonUSA
  3. 3.Department of Physiology and Biophysics, School of Basic Medical SciencesUniversity of IllinoisUrbanaUSA

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