Effect of Porcine Relaxin on Cyclic Nucleotide Levels and Spontaneous Contractions of the Rat Uterus
Relaxin has been known for some time to inhibit spontaneous uterine contractions in a number of species (Schwabe et al., 1978). Furthermore a number of studies have indicated that circulating factors in addition to steroid hormones regulate uterine contractility and responsiveness during pregnancy (Porter, 1972; Korenman et al., 1974; Porter and Downing, 1978). In the human, serum relaxin levels are elevated early in pregnancy, suggesting that this hormone may play a role in maintaining uterine quiescence during that period (Quagliarello et al., 1979).
KeywordsCyclic Nucleotide Adenylate Cyclase Activity Spontaneous Contraction Estradiol Benzoate Uterine Contractility
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- Andersson, R. G. G. and Nilsson, K. B. (1977). Role of cyclic nucleotides: Metabolism and mechanical activity in smooth muscle, In: The Biochemistry of Smooth Muscle, N. L. Stephans, ed., University Park Press, Baltimore, MD. p. 263.Google Scholar
- Bryant-Greenwood, G, Mercado-Simmen, Rosalia, Yamamoto, Sandra Y., Arakaki, R. F., Uchima, F. D. A. and Greenwood, F. C. (1981). Relaxin receptors and a study.of the physiological roles of relaxin. 15th Midwest Conference on Endocrin. and Metab.Google Scholar
- Diamond, J. (1977). Evidence for dissociation between cyclic nucleotide levels and tension in smooth muscle. In: “The Biochemistry of Smooth Muscle” H. L. Stephans, ed., University Park Press, Baltimore, MD. p. 343.Google Scholar
- Diamond, J. and Hartle, K. D. (1976). Cyclic nucleotide levels during carbachol-induced smooth muscle contractions. J. Cycl. Nucleotide Res. 2: 179.Google Scholar
- Heindel, J. J., Hiritz, M. I., Steinberger, E. and Strada, S. J. (1978). The effect of FSH on cyclic nucleotide levels in testicular tissue from rats of various ages: Non correlation with cyclic nucleotide phosphodiesterase activity. Endocrine Res. Commun. 4: 6.Google Scholar
- Korenman, S. G., Bhalla, R. C., Wortsman, J., Stevens, R., Wells, L.and Carpenter, L. (1974). Hormonal regulation of uterine contractility: The role of the adenylate cyclase system. J. Steroid Biochem. 5: 905.Google Scholar
- Layne, E. (1957). Protein estimation with the Folin-Ciocalteu method, In: Methods in Enzymology. S. P. Colowick and N. 0. Kaplan, ed. Vol. Ill, Academic Press, NY p. 448.Google Scholar
- McMurtry, J. P., Kwok, S. C. M. and Bryant-Greenwood, G. Ij (1978). Target tissues for relaxin identified in vitro with I- labelled porcine relaxin. J. Reprod. Fert. 52: 209.Google Scholar
- Quagliarello, J., Steinetz, F. G. and Weiss, G. (1979). Relaxin secretion in early pregnancy. Obstet. Gyn. 53:62.Google Scholar
- Harbon, S., Vesin, M. F., Khac, L. D. and Leiber, D. (1978). Cyclic nucleotides in the regulation of rat uterus contractility. In: Molecular Biology and Pharmacology of Cyclic Nucleotides, G. Folco and R. Paolette, eds., Elsevier, Holland. p. 279.Google Scholar