Advertisement

Why are Selectively Responsive and Multireceptive Neurons Both Present in Somatosensory Pathways?

  • Edward R. Perl
Chapter
Part of the Wenner-Gren Center International Symposium Series book series (EMISS, volume 12)

Abstract

It is a particular privilege to join in this symposium honoring Yngve Zotterman. His gracious hospitality and enthusiasm for science was an inspiration to me as to so many others. My invitation asked for an overview for the presentations to follow in this session, a rather difficult task because of the scope of the topics involved. I have chosen instead to offer a theory about a feature of the organization of the somatosensory system that touches on the several topics, with the realization that while speculation in science is a precarious game, it would have pleased Yngve Zotterman; he loved to practice it.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anderson, S.A., Landgren, S., Wolsk, D., (1966). The thalamic relay and cortical projection of group I muscle afferents from the forelimb of the cat. J. Physiol., Lond., 183, 576–591Google Scholar
  2. Angaut-Petit, D. (1975a). The dorsal column system: I. Existence of long ascending postsynaptic fibres in the cat’s fasciculus gracilis. Expl. Brain Res., 22, 457–470Google Scholar
  3. Angaut-Petit, D. (1975b). The dorsal column system: II. Functional properties and bulbar relay of the postsynaptic fibres of the cat’s fasciculus gracilis. Expl. Brain Res., 22, 471–493Google Scholar
  4. Bessou, P., Perl, E.R., (1969). Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J. Neurophysiol., 32, 1025–1043PubMedGoogle Scholar
  5. Boivie, J.J.G., Perl, E.R. (1975). Neural substrates of somatic sensation. In Neurophysiology I. (ed. C.C. Hunt ). University Park, BaltimoreGoogle Scholar
  6. Brown, A.G. (1973). Ascending and long spinal pathways: dorsal columns, spinocervical tract and spinothalamic tract. In Handbook of Sensory Physiology. Somatosensory System. (ed. A. Iggo). Springer-Verlag, BerlinGoogle Scholar
  7. Brown, A.G. (1981). Organization in the Spinal Cord. Springer-Verlag, BerlinCrossRefGoogle Scholar
  8. Brown, A.G., Hamann, W.C., Martin, H.F., III. (1975). Effects of activity in non-myelinated afferent fibres on the spinocervical tract. Brain Res., 98, 243–259PubMedCrossRefGoogle Scholar
  9. Brown, A.G., Iggo, A. (1967). A quantitative study of cutaneous receptors and afferent fibres in the cat and rabbit. J. Physiol., Land., 193, 707–733Google Scholar
  10. Burgess, P.R., Perl, E.R., (1973). Cutaneous mechanoreceptors and nociceptors. In Handbook of Sensory Physiology. Somatosensory System. (ed. A. Iggo). Springer-Verlag, BerlinGoogle Scholar
  11. Chung, J.M., Kenshalo, D.R., Jr., Gerhart, K.D., Willis, W.D. (1979). Excitation of primate spinothalamic neurons by cutaneous C-fiber volleys. J. Neurophysiol., 42, 1354–1369PubMedGoogle Scholar
  12. Frey, M. von. (1897). Beiträge zur Sinnesphysiologie der Haut (Part IV). Koenig1. Saechs. Ges. Wiss., Math.-Phys. Klasse, 49, 462–468Google Scholar
  13. Guilbaud, G. (1983). Organization of noxious and non-noxious inputs in SmI cortex: comparison in normal and in arthritic rats. Presentation at symposium on Somatosensory Mechanisms held at Stockholm, Sweden, June 8–10, 1983. Published in this volumeGoogle Scholar
  14. Honda, C.N., Mense, S., Perl, E.R. (1983). Neurons in ventrobasal region of cat thalamus selectively responsive to noxious mechanical stimulation. J. Neurophysiol., 49, 662–673PubMedGoogle Scholar
  15. Iggo, A. (1980). Presentation at Satellite Symposium of the International Congress of Physiological Sciences held at Keszthely, Hungary, July 9–12, 1980Google Scholar
  16. Kenshalo, D.R., Jr., Leonard, R.B., Chung, J.M., Willis, W.D. (1979). Responses of primate spinothalamic neurons to graded and to repeated noxious stimuli. J. Neurophysiol., 42, 1370–1389PubMedGoogle Scholar
  17. Kenshalo, D.R., Jr., Giesler, G.J., Jr., Leonard, R.B., Willis, W.D. (1980). Responses of neurons in primate ventral posterior lateral nucleus to noxious stimuli. J. Neurophysiol., 43, 1594–1614PubMedGoogle Scholar
  18. Kenshalo, D.R., Jr., Isensee, O., (1983). Effects of noxious stimuli on primate SI cortical neurons. In Advances in Pain Research and Therapy. (eds. J.J. Bonica, U. Lindblom, A. Iggo,). Raven Press, New YorkGoogle Scholar
  19. Kniffki, K.-D., Mizumura, K., (1983). Responses of neurons in VPL and VPL-VL region of the cat to algesic stimulation of muscle and tendon. J. Neurophysiol., 49, 649–661PubMedGoogle Scholar
  20. Kumazawa, T., Perl, E.R., Burgess, P.R., Whitehorn, D. (1975). Ascending projections from marginal zone (lamina I) neurons of the spinal dorsal horn. J. Comp. Neural., 162, 1–11CrossRefGoogle Scholar
  21. Lundberg, A., Oscarsson, O., (1962). Two ascending spinal pathways in the ventral part of the cord. Acta physiol. scand., 54, 270–286PubMedCrossRefGoogle Scholar
  22. Magoun, H.W., Rhines, R. (1947). Spasticity - The Strength Reflex and Extra-Pyramidal Systems. Charles C. Thomas, Springfield, IllGoogle Scholar
  23. Mayer, D.J., Price, D.D., Becker, D.P. (1975). Neurophysiological characterization of the anterolateral spinal cord neurons contributing to pain perception in man. Pain, 1, 51–58PubMedCrossRefGoogle Scholar
  24. Melzack, R., Wall, P.D. (1962). On the nature of cutaneous sensory mechanisms. Brain, 85, 331–356PubMedCrossRefGoogle Scholar
  25. Müller, J., (1840). Handbuch der Physiologie des Menschen. J. Hölscher, CoblenzGoogle Scholar
  26. Müller, J., (1842). Elements of Physiology. Taylor and Walton, LondonGoogle Scholar
  27. Perl, E.R., Whitlock, D.G., Gentry, J.R., (1961). Cutaneous projection to second-order neurons of the dorsal column system. J. Neurophysiol., 25, 337–358Google Scholar
  28. Poggio, G.F., Mountcastle, V.B., (1960). A study of the functional contributions of the lemniscal and spinothalamic systems to somatic sensibility. Bull. Johns Hopkins Hosp., 106, 266–316PubMedGoogle Scholar
  29. Poggio, G.F., Mountcastle, V.B. (1963). The functional properties of ventrobasal thalamic neurons studied in unanesthetized monkeys. J. Neurophysiol., 26, 775–806PubMedGoogle Scholar
  30. Rastad, J., Jankowska, E., Westman, J. (1977). Arborization of initial axon collaterals of spinocervical tract cells stained intracellularly with horseradish peroxidase. Brain Res., 135, 1–10PubMedCrossRefGoogle Scholar
  31. Rose, J.E., Mountcastle, V.B., (1959). Touch and kinesthesia. In Handbook of Physiology, Section 1 - Neurophysiology, v. 1. (eds. J. Field, H.W. Magoun ). American Physiological Society, Washington, D.CGoogle Scholar
  32. Rustioni, A. (1973). Non-primary afferents to the nucleus gracilis from the lumbar cord of the cat. Brain Res., 51, 81–95PubMedCrossRefGoogle Scholar
  33. Sinclair, D.C. (1955). Cutaneous sensation and the doctrine of specific energy. Brain, 78, 584–614PubMedCrossRefGoogle Scholar
  34. Trevino, D.L., Coulter, J.D., Willis, W.D. (1973). Location of cells of origin of spinothalamic tract in lumbar enlargement of the monkey. J. Neurophysiol., 36, 750–761PubMedGoogle Scholar
  35. Uddenberg, N. (1968). Functional organization of long, secondorder afferents in the dorsal funiculus. Expl. Brain Res., 4, 377–382Google Scholar
  36. Willis, W.D. (1982). Control of nociceptive transmission in the spinal cord. In Progress in Sensory Physiology 3. (ed. D. Ottoson). Springer-Verlag, BerlinGoogle Scholar
  37. Witt, I., Hensel, H. (1959). Afferente Impulse aus der Extremitätenhaut der Katze bei thermischer and mechanischer Reizung. Pflügers Arch, ges. Physiol., 268, 582–596CrossRefGoogle Scholar
  38. Zotterman, Y. (1939). Touch, pain and tickling: An electrophysiological investigation on cutaneous sensory nerves. J. Physiol., Lond., 95, 1–28PubMedCentralPubMedGoogle Scholar

Copyright information

© The Wenner-Gren Center 1984

Authors and Affiliations

  • Edward R. Perl
    • 1
  1. 1.University of North Carolina at Chapel HillUSA

Personalised recommendations