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Organization of Noxious and Non-Noxious Inputs in SmI Cortex: Comparison in Normal and in Arthritic Rats

  • G. Guilbaud
  • Y. Lamour
  • J. C. Willer
Chapter
Part of the Wenner-Gren Center International Symposium Series book series (EMISS, volume 12)

Abstract

Experimental evidence for a noxious input to the cerebral somatosensory neocortex is so far very limited. Observations suggesting that the cerebral cortex is actually not directly involved in pain mechanisms have been reported (Penfield and Rasmussen 1950). However, preliminary observations of somatosensory cortical neurones driven by noxious stimuli have been reported in cat and monkey (see references in Lamour et al., 1983 a et b).

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References

  1. Armstrong-James, M., (1975) The functional status and columnar organization of single cells responding to cutaneous stimulation in neonatal rat somatosensory cortex SI. J. Physiol (Lond) 246, 501–538Google Scholar
  2. Chapin, J.K., Lin, C.S., Woodward D.J (1930) Laminar differences in the size and shape of receptive fields in rat somatosensory (SI) cortex. 10th Annual Meeting, Cincinnati. Neuroscience Abstr. 6, 62Google Scholar
  3. Gautron, M., Guilbaud, G., (1982) Somatic responses of ventrobasal thalamic neurones in polyarthritic rats. Brain Res. 237, 459–471PubMedCrossRefGoogle Scholar
  4. Gouret, C., Mocquet G., Raynaud G (1976) Use of Freund’s adjuvant arthritis test in anti-inflammatory drug screening in the rat: value of animal selection and preparation at the breeding center. Lab-Anim-Sci 26, 281–287PubMedGoogle Scholar
  5. Guilbaud, G., Peschanski, M., Gautron, M., Binder D., (1980) Neurones responding to noxious stimulation in VB complex and caudal adjacent regions in the thalamus of the rat. Pain 8, 303–318PubMedCrossRefGoogle Scholar
  6. Herkenham, M., (1980) Laminar organization of thalamic projections to the rat neocortex. Science 207, 532–535PubMedCrossRefGoogle Scholar
  7. Iggo, A., Guilbaud, G., Tegner, R., (1983) Sensory mechanisms in arthritic rats. In pressGoogle Scholar
  8. Jones, E.G., Friedman, D.P., Hendry, S.H.C (1982) Thalamic basis of place-and modality-specific columns in monkey somatosensory cortex: a correlative anatomical and physiological study. J. Comp. Neurol. 48, 545–568Google Scholar
  9. Lamour, Y., Willer, J.C., Guilbaud, G (1983) Rat somatosensory SmI cortex: I characteristics of neuronal responses to noxious stimulation and comparison with responses to non-non noxious stimulation. Exp. Brain Res. 49, 39–45Google Scholar
  10. Lamour, Y., Guilbaud, G., Willer, J.C., (1983) Rat somatosensory SmI cortex: II laminar and columnar organization of noxious and non-noxious inputs. Exp. Brain Res. 49, 46–54PubMedGoogle Scholar
  11. Landry P., Deschenes M (1981) Intracortical arborizations and receptive fields of identified ventrobasal thalamo-cortical afferents to the primary somatic sensory cortex in the cat. J. Comp. Neural. 199, 345–371CrossRefGoogle Scholar
  12. Ménétrey D., Besson J.M., (1982) Electrophysiologcial characteristics of dorsal horn cells in rats with cutaneous inflammation resulting from chronic arthritis. Pain 13, 343–364PubMedCrossRefGoogle Scholar
  13. Merzenich M.M., Kaas J.H (1982) Reorganization of mammalian somatosensory cortex following peripheral nerve injury. Trends in Neuroscience. dec, 434–436Google Scholar
  14. Mountcastle V.B (1957) Modality and topographic properties of single neurons of cat’s somatic sensory cortex. J. Neurophysiol. 20, 408–434PubMedGoogle Scholar
  15. Pearson, C.M., Wood, F.D., (1959) Studies of polyarthritis and other lesions induced in rats by injection of mycrobacterial adjuvant. I: General clinical and pathological characteristics and some modifying factors. Arthr Rheum 2, 440–459CrossRefGoogle Scholar
  16. Penfield W., Rasmussen T (1950) The cerebral cortex of man. A clinical study of localization of function. Hafner, New York. Penny G.R., Itoh K., Diamond I.T. (1982) Cells of different sizes in the ventral nuclei project to different layers of the somatic cortex in the cat. Brain Res. 242, 55–65Google Scholar
  17. Peschanski, M., Guilbaud, G., Gautron, M., Benson J.M., (1980) Encoding of noxious heat messages in neurons of the ventrobasal thalamic complex of the rat. Brain Res. 197, 401–413PubMedCrossRefGoogle Scholar
  18. Peschanski M., Guilbaud G., Gautron M (1981) Posterior intralaminar region in rat: Neuronal responses to noxious and non-noxious cutaneous stimuli. Exp. Neurol. 72, 226–238PubMedCrossRefGoogle Scholar
  19. Powell T.P.S., Mountcastle V.B (1959) Some aspects of the functional organization of the cortex of the post-central gyrus of the monkey: A correlation of findings obtained in a single unit analysis with cytoarchitecture. Bull Johns Hopkins Hosp. 105, 133–162PubMedGoogle Scholar
  20. Saporta S., Kruger L (1977) The organization of thalamo-cortical relay neurons in the rat ventrobasal complex studied by the retrograde transport of horseradish peroxidase. J. Comp. Neurol. 174, 187–203PubMedCrossRefGoogle Scholar
  21. Simons D.J (1978) Response properties of vibrissa. units in rat SI somatosensory neocortex. J. Neurophysiol. 41, 798–820PubMedGoogle Scholar
  22. Welker C (1976) Receptive fields of barrels in the somatosensory neocortex of the rat. J. Comp. neurol. 166, 173–190PubMedCrossRefGoogle Scholar
  23. White E.L (1978) Identified neurons in mouse SmI cortex which are postsynaptic to thalamocortical axon terminals: A combined Golgi-electron microscopic and degeneration study. J. Comp. neurol. 181, 627–662PubMedCrossRefGoogle Scholar

Copyright information

© The Wenner-Gren Center 1984

Authors and Affiliations

  • G. Guilbaud
    • 1
  • Y. Lamour
    • 1
  • J. C. Willer
    • 1
  1. 1.Laboratoire de Neurophysiologie Pharmacologique INSERM U.161ParisFrance

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