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The Granuloma Pouch Assay

  • Peter Maier
Chapter

Abstract

Chemicals to which man is potentially exposed or that are already distributed in the environment are tested for their mutagenic activity in simple, inexpensive screening tests utilizing prokaryotic and/or eukaryotic cells. These phase I or tier I tests should have a low potential to produce false negative results. This is often achieved by the acceptance of a certain number of false positive results. Therefore chemicals that show positive, contradictory, or inconclusive results in this battery of tier I tests and are still of importance should be further tested in phase II (tier II) tests to provide a broader basis on which risk assessment can be made.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Peter Maier
    • 1
  1. 1.Institute of ToxicologySwiss Federal Institute of Technology and University of ZurichSchwerzenbachSwitzerland

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