Induction of Bacteriophage Lambda by DNA-Interacting Chemicals

  • Rosalie K. Elespuru


Induction of resident prophages in coliform bacteria occurs as an indirect consequence of damage to the DNA of the host bacteria. The change in bacteriophage gene expression from the repressed to the active state (induction) is one of the manifestations of the “SOS response,” among such others as mutagenesis, increased DNA repair activity, filamentation, and suppression of respiration.(33,50,53,64,71)The SOS functions have in common the property of being controlled at the level of transcription by repressors that bind to DNA and prevent its expression. Prophages are regulated by specific repressors encoded by phage genes, while many other SOS functions are repressed by a single repressor protein called LexA. The operator regions adjacent to the genes encoding these SOS functions contain sequences to which LexA protein,(10,58) or phage repressors such as lambda, bind.


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© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Rosalie K. Elespuru
    • 1
  1. 1.Fermentation Program NCI–Frederick Cancer Research FacilityFrederickUSA

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