Clinical Relevance of Endotoxemia

  • James P. Nolan
Part of the University of South Florida International Biomedical Symposia Series book series (EMISS, volume 18)


Endotoxins are in the outer cell wall of gram-negative bacteria. While endotoxins contain protein, the toxic portion is composed of lipopolysaccharides (LPS) and the terms are often used interchangeably. The innermost portion is lipid A and this moiety demonstrates all the biological effects of this potent material, and is similar in structure among most endotoxins. Endotoxin is formed by death of bacteria as well as by vesicle formation and release by the living bacterium.


Liver Injury Acute Renal Failure Bile Salt Kupffer Cell Obstructive Jaundice 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • James P. Nolan
    • 1
  1. 1.Department of MedicineState University of New York at Buffalo School of MedicineBuffaloUSA

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