A novel leukocyte chemotactic and activating cytokine, interleukin-8 (IL-8)

  • Naofumi Mukaida
  • Akihisa Harada
  • Kouji Matsushima
Part of the Cancer Treatment and Research book series (CTAR, volume 80)


Inflammation occurs as a host defensive reaction to tissue injuries caused by various inciting stimuli and is inevitably associated with leukocyte infiltration into a site of inflammation. Limited types of leukocytes infiltrate, depending upon the type, degree, and timing of tissue injuries [1]. Several leukocyte chemotactic factors such as C5a, leukotriene B4, and bacteria-derived formyl peptide have been long described [2]. However, these factors can induce Chemotaxis of any type of leukocytes, thus suggesting the existence of a cell-type-specific leukocyte chemotactic factor(s) in addition to these nonspecific ones.


Human Neutrophil Neutrophil Infiltration Adult Respiratory Distress Syndrome Chemotactic Activity T98G Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Kluwer Academic Publishers 1995

Authors and Affiliations

  • Naofumi Mukaida
  • Akihisa Harada
  • Kouji Matsushima

There are no affiliations available

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