Over the last decade, the most radical change in percutaneous coronary intervention (PCI) practice has been the rapid incorporation of intracoronary stenting, to the extent that it is now used in well over 80% of all angioplasty procedures. This change in practice has occurred as a consequence of landmark studies, such as STRESS (Stent Restenosis Study) and BENESTENT (Belgian Netherlands Stent) [1, la]. These studies demonstrated conclusively that stenting could reduce restenosis after coronary intervention. Nevertheless, significant rates of in-stent restenosis, on the order of 20% to 30% (angiographic restenosis), still occur, presenting a challenging problem .
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