Immunotherapy of Microbial Diseases

  • K. Noel Masihi


Marvels of modem medicine have apparently tamed a multitude of microbial infections. Vaccination has had a major impact in the control of important diseases including smallpox, yellow fever, polio, measles, mumps, rubella, diphtheria, tetanus, and pertusis. It is, nonetheless, enlightening to note that immunotherapeutic intervention in the form of immunization predates the postulates of infection or immunology. Edward Jenner discovered the smallpox vaccination in 1780. Since then only around 25 vaccines against various infectious diseases have been licensed and general widespread use has been restricted to about 10 vaccines. It is disconcerting that there are a vast number of diseases afflicting humans and domestic mammals for which no vaccines or specific chemotherapy will be available in the near future. In addition, infections that caused ravages in the 19th century, such as tuberculosis, are resurging with vehemence. Recent episodes of plague, diphtheria, cholera, and Ebola virus, diseases long thought to be under control, have heightened public awareness of infectious diseases.


Human Immunodeficiency Virus Human Immunodeficiency Virus Type Human Immunodeficiency Virus Infection Human Immunodeficiency Virus Replication Rift Valley Fever Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1996

Authors and Affiliations

  • K. Noel Masihi
    • 1
  1. 1.Robert Koch Institute, Federal Institute for Infectious and Non-Communicable DiseasesBerlinGermany

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