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Trace Amines pp 301-305 | Cite as

Catecholamine Uptake into Cultured Mouse Astrocytes

  • John X. Wilson
  • Wolfgang Walz
Chapter
Part of the Experimental and Clinical Neuroscience book series (ECN)

Abstract

Earlier studies have suggested that glial cells may influence neuronal signalling in the brain. In particular, uptake and metabolism by glial cells may terminate the actions of the catechol aminergic transmitters released from neurons (Henn and Hamberger, 1971; Pelton et al., 1981; Kimelberg and Pelton, 1983). Thus, regulation of glial transport and metabolic activities may provide a mechanism for modulating neurotransmission. Ascorbic acid is stored within catecholaminergic neurons and is secreted with neurotransmitters (O’Neill et al., 1984; Kratzing et al., 1985). One function for ascorbic acid is the retardation of oxidative processes that degrade and inactivate catecholamines; in other words, ascorbic acid may serve as a chemical preservative for catecholamines within neurons and in extracellular fluid. However, because the termination of the neurophysiological actions of catecholamines also is effected by cellular uptake, it is of interest to know if ascorbic acid alters the catecholamine uptake process.

Keywords

Ascorbic Acid Catecholaminergic Neuron Mouse Astrocyte Saturable Component Chemical Preservative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Humana Press Inc. 1988

Authors and Affiliations

  • John X. Wilson
    • 1
  • Wolfgang Walz
    • 2
  1. 1.Department of Physiology, Health Sciences CentreThe University of Western OntarioLondonCanada
  2. 2.Department of PhysiologyUniversity of SaskatchewanSaskatoonCanada

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