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Pathogenesis of Age-Dependent Poliomyelitis of Mice

Viral and Immunological Factors Contributing to Fatal Paralysis
  • Christopher H. Contag
  • John T. Harty
  • Peter G. W. Plagemann
Chapter

Abstract

Lactate dehydrogenase-elevating virus (LDV) is a generally nonpathogenic mouse virus (for reviews see refs. 1, 2, 3, 4, 5). LDV infections in most strains of Mus musculus usually result in lifelong, persistent, asymptomatic infections. However, in highly leukemic strains of mice, peripheral inoculations of LDV can result in a fatal paralytic disease (6, 7) that has been shown to involve direct cytopathic effects of LDV infections on motor neurons (see Section 3. ). LDV infection of motor neurons is dependent on the expression of an endogenous, ecotropic murine leukemia virus (MLV) in these cells (see Section 4. ). Susceptibility in genetically predisposed strains of mice is related to the age of the animals at the time of LDV infection (6, 7, 8); hence, the neurological disease is referred to as age-dependent poliomyelitis (ADPM). The age at which mice become susceptible can be modulated by immunosuppressive agents, such as cyclophosphamide and X-irradiation (6, 7, 9, 20). In addition to the genetic and viral factors involved in the development of ADPM, humoral and cellular immune functions appear to control both the initiation and the progression of the neurological disease caused by LDV (see Section 5. ).

Keywords

Spinal Cord Motor Neuron Murine Leukemia Virus Nonneuronal Cell Equine Arteritis Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Christopher H. Contag
  • John T. Harty
  • Peter G. W. Plagemann

There are no affiliations available

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