Intensive Care for Patients with Malignant Disease

  • C. J. Hinds
  • A. M. Oza


“Malignant tumours vary very much, both in their rate of local growth and dissemination, but they are always ultimately fatal, the average duration of life being from three to six months in the case of sarcoma, and from two to three years in the case of carcinoma, whether the condition be treated or not…” [141].


Disseminate Intravascular Coagulation Acute Myelogenous Leukaemia Acute Leukaemia Neutropenic Patient Tumour Lysis Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Adler A, Stein JA, Ben-Efraim S (1980) Immunocompetence, immunosuppression and human breast cancer II. Further evidence of initial immune impairment by integrated assessment effect of nodal involvement (N) and of primary tumour size (T). Cancer 45: 2061–2073; 2074–2083PubMedCrossRefGoogle Scholar
  2. 1a.
    Addison IE, Johnson B, Devereux S et al. (1989) Granulocyte-macrophage colony stimulating factor may inhibit migration in vivo. Clin Exp Immunol 76: 149–153PubMedGoogle Scholar
  3. 2.
    Adonis C (1983) Problems encountered in an intensive care medical oncology unit in Paris. Proceedings 130th International Cancer Congress: Cancer Management. Liss, New York, pp 423–426Google Scholar
  4. 3.
    Alavi JB, Root RK, Djerassi I et al. (1977) A randomized clinical trial of granulocyte transfusion for infection in acute leukaemia. N Engl J Med 296: 706–711PubMedCrossRefGoogle Scholar
  5. 4.
    Ambrus JL, Ambrus CM, Mink IB, Pickern JW (1975) Causes of death in cancer patients. J Med 6: 61–64PubMedGoogle Scholar
  6. 5.
    Anderson HA, Fontana RS (1972) Transbronchoscopic lung biopsy for diffuse pulmonary diseases: technique and results in 450 cases. Chest 62: 125–128CrossRefGoogle Scholar
  7. 6.
    Anderson ET, Young LS, Hewitt WL (1978) Antimicrobial synergism in the therapy of gram-negative rod bacteremia. Chemotherapy 24: 45–54PubMedCrossRefGoogle Scholar
  8. 7.
    Anger B, Schmeiser T, Sigel H, Heimpel H (1987) Intensive care therapy for patients with hematological diseases. Haematol Bluttransfus 30: 519–523Google Scholar
  9. 8.
    Antman KS, Griffin JD, Elias A et al. (1988) Effect of recombinant human granulocyte macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med 319: 593–598PubMedCrossRefGoogle Scholar
  10. 8a.
    Antman K, Griffin J, Elias A et al. (1987) Use of recombinant human granulocyte-macrophage colony stimulating factor to ameliorate chemotherapy myelosuppression in sarcoma patients. Blood Supp J 70: 373Google Scholar
  11. 9.
    Armstrong BA, Perez CA, Simpson JR, Hederman MA (1987) Role of irradiation in the management of superior vena cava syndrome. Int J Radiat Oncol Biol Phys 13: 531–539PubMedCrossRefGoogle Scholar
  12. 10.
    Averette HE, Lichtinger M, Sevin BU, Girtanner RE (1984) Pelvic exenteration: a 15 year experience in a general metropolitan hospital. Am J Obstet Gynecol 150: 179–184PubMedGoogle Scholar
  13. 11.
    Bandt PD, Blank N, Castellino RA (1972) Needle diagnosis of pneumonitis: Value in high risk patients. JAMA 220: 1578–1580PubMedCrossRefGoogle Scholar
  14. 12.
    Baniel J, Lombrozo R, Ziv Y, Wolloch Y (1988) Neutropenic enterocolitis. Acta Chir Scand 154: 71–73PubMedGoogle Scholar
  15. 13.
    Beachey EH (1981) Bacterial adherence: adhesin-receptor interactions mediating the attachment of bacteria to mucosal surfaces. J Infect Dis 143: 325–345PubMedCrossRefGoogle Scholar
  16. 14.
    Benezra D, Gold JWM, Armstrong D (1986) Indwelling central venous catheter infections. In: Proceedings of 4th international symposium on infections in the immunocompromised host. Ronneby Brunn, SwedenGoogle Scholar
  17. 15.
    Bennett OE, Million RR, Acekerman LV (1969) Bilateral radiation pneumonitis: a complication of the radiotherapy of bronchogenic carcinoma. Cancer 23: 1001–1018PubMedCrossRefGoogle Scholar
  18. 16.
    Beretta E, Villani F (1980) Cardiomyopathy in adults after combination adriamycin and DTIC. Cancer Treatment Rep 64: 353Google Scholar
  19. 17.
    Bertolini DR, Nedwin GE, Bringman TS, Smith DD, Mundy GR (1986) Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature 319: 516–518PubMedCrossRefGoogle Scholar
  20. 18.
    Blacklock HA, Griffiths P, Stirk P, Prentice HG (1986) Cytotect treatment of cytomegalovirus pneumonitis after matched allogeneic bone marrow transplantation. In: Proceedings of 4th international symposium on infections in the immunocompromised host. Ronneby Brunn, Sweden, p 33Google Scholar
  21. 19.
    Blume KG, Petz LD (eds) (1983) Clinical bone marrow transplantation. Churchill Livingstone, EdinburghGoogle Scholar
  22. 20.
    Bodey GP (1966) Fungal infectious complicating acute leukaemia. J Chronic Dis 19: 667PubMedCrossRefGoogle Scholar
  23. 21.
    Bodey GP, Bolivar R, Fainstein AV (1982) Infectious complications in leukemic patients. Semin Hematol 19: 193–226PubMedGoogle Scholar
  24. 22.
    Bodey GP, Buckley M, Sathe YS et al. (1966) Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 64: 328–340PubMedGoogle Scholar
  25. 23.
    Bodey GP, Rodriguez V, Chang H-Y, Narboni G (1978) Fever and infection in leukaemic patients: a study of 494 consecutive patients. Cancer 41: 1610–1622PubMedCrossRefGoogle Scholar
  26. 24.
    Brandt SJ, Peters WP, Atwater SK et al. (1988) Effect of recombinant human granulocyte-macrophage colony stimulating factor on haematopoietic reconstitution after high dose chemotherapy and autologous bone marrow transplantation. N Eng J Med 318: 869–876CrossRefGoogle Scholar
  27. 25.
    Brennan JT (1987) Oncologic emergencies and paraneoplastic syndromes. Primary Care 14: 365–379PubMedGoogle Scholar
  28. 26.
    Brettler DB (1985) Granulocytopenia. In: Rippe JM, Irwin RS, Alpert JS, Dalen JE (eds) Intensive care medicine. Little, Brown & Co, Boston, pp 846–853Google Scholar
  29. 27.
    Bronchud MH, Scarffe JH, Thatcher N et al. (1987) Phase I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 56: 809–813PubMedCrossRefGoogle Scholar
  30. 28.
    Brown AE (1984) Neutropenia, fever and infection. Am J Med 76: 421–428PubMedCrossRefGoogle Scholar
  31. 28a.
    Brunet F, Lanore JJ, Dhainaut JF et al. (1990) Is intensive care justified for patients with haematological malignancies? Intensive Care Med 16: 291–297PubMedCrossRefGoogle Scholar
  32. 29.
    Buja LM, Ferrans VH (1975) Myocardial injury produced by antineoplastic drugs. Recent Adv Stud Cardiac Struct Metab 6: 487PubMedGoogle Scholar
  33. 30.
    Carlon GC (1978) Respiratory failure in cancer patients. Curr Probl Cancer 4: 47–57CrossRefGoogle Scholar
  34. 31.
    Carlon GC, Ray C Jr, Klein R et al. (1978) Criteria for selective positive end expiratory pressure and independent synchronised ventilation for each lung. Chest 74: 501–507PubMedCrossRefGoogle Scholar
  35. 32.
    Castellino RA, Blank N (1979) Etiological diagnosis of focal pulmonary infection in immunocompromised patients by fluoroscopically guided percutaneous needle aspiration. Radiology 132: 563–567PubMedGoogle Scholar
  36. 33.
    Chang HY, Rodriguez V, Narboni G et al. (1976) Causes of death in adults with acute leukaemia. Medicine 55: 259–268PubMedCrossRefGoogle Scholar
  37. 34.
    Chillar RK, Belman MJ, Farbstein M et al. (1980) Explanation for apparent hypoxaemia associated with extreme leukocytosis: leucocytic oxygen consumption. Blood 55: 922–924PubMedGoogle Scholar
  38. 35.
    Co-operative Group for the Study of Immunoglobulin in Chronic Lymphocytic Leukaemia (1988) Intravenous immunoglobulin for the prevention of infection in chronic lymphocytic leukaemia. N Eng J Med 319:902–907CrossRefGoogle Scholar
  39. 36.
    Cockerill FR, Wilson WR, Carpenter HA, Smith TF, Rosendow EC (1985) Open lung biopsy in immunocompromised patients. Arch Intern Med 145: 1398–1404PubMedCrossRefGoogle Scholar
  40. 37.
    Cox SC, Norwood SM, Duncan CA (1985) Acute respiratory failure: mortality associated with underlying disease. Crit Care Med 13: 1005–1008PubMedCrossRefGoogle Scholar
  41. 38.
    Clift RA, Sanders JE, Thomas ED, Williams B, Buckner CD (1978) Granulocyte transfusions for the prevention of infection in patients receiving bone-marrow transplants. N Engl J Med 298: 1052–1057PubMedCrossRefGoogle Scholar
  42. 38a.
    Crawford SW, Schwartz DA, Peterson F et al. (1988) Risk factors in mechanical ventilation after marrow transplantation. Am Rev Respir Dis 137: 682–687PubMedGoogle Scholar
  43. 39.
    Cunningham JH, Zavala DC, Corry RJ et al. (1977) Trephine air drill, bronchial brush and fibreoptic transbronchial lung biopsies in immunosuppressed patients. Am Rev Resp Dis 115: 213–220PubMedGoogle Scholar
  44. 40.
    Deeg HJ (1988) Acute graft vs host disease. In: Deeg HJ, Klingemann HG, Phillips GL (eds) Bone marrow transplantation. Springer-Verlag, Berlin, pp 86–98CrossRefGoogle Scholar
  45. 41.
    Delamore IW (1986) Multiple myeloma and other paraproteinaemias. Churchill Livingstone, Edinburgh, 324–325Google Scholar
  46. 41a.
    Devereux S, Linch DC, Patterson KP et al. (1989) Granulocyte-macrophage colony stimulating factor accelerates neutrophil recovery after autologous bone marrow transplantation in Hodgkin’s disease: bone marrow transplantation. 4: 49–54Google Scholar
  47. 42.
    Dick JD, Shull V, Karp JE, Valentine J (1988) Bacterial and host factors affecting Pseudomonas aeruginosa colonization versus bacteremia in granuloctyopenic patients. Eur J Cancer Clin Oncol 24 (suppl 1): S47–S54PubMedGoogle Scholar
  48. 42a.
    Dragsted L, Quist J, Madsen M (1989) Outcome from intensive care II. A 5 year study of 1308 patients: short term outcome. Eur J Anaesth 6: 131–144Google Scholar
  49. 43.
    Drapkin RL, Gee TS, Dowling MD et al. (1978) Prophylactic heparin therapy in acute promyelocytic leukemia. Cancer 41: 2484–2490PubMedCrossRefGoogle Scholar
  50. 44.
    Eisenberg RL (1985) Diagnostic imaging in internal medicine. McGraw-Hill, New YorkGoogle Scholar
  51. 45.
    Elvin KM, Bjorkman A, Linder E, Heurlin N, Hjerpe A (1988) Pneumocystis carinii pneumonia: detection of parasites in sputum and bronchoalveolar lavage fluid by monoclonal antibodies. Br Med J 297: 381–384CrossRefGoogle Scholar
  52. 46.
    Engelhard D, Aker M, Lugassy G et al. (1986) Combined therapy with intravenous immune globulin and granulocyte transfusions in uncontrolled overwhelming Pseudomonas aeruginosa septicaemia in neutropenic cancer patients. In: Proceedings of the 4th international symposium on infections in the immunocompromised host. Ronneby Brunn, Sweden, p 89Google Scholar
  53. 47.
    Ersek MT (1984) Clinical reviews in critical care: the adult leukemia patient in the intensive care unit. Heart Lung 13: 183–193PubMedGoogle Scholar
  54. 48.
    Estopa R, Marti AT, Kastanos N et al. (1984) Acute respiratory failure in severe hematological disorders. Crit Care Med 12: 26–29PubMedCrossRefGoogle Scholar
  55. 49.
    Ewer MS, Ali MK, Atta MS et al. (1986) Outcome of lung cancer patients requiring mechanical ventilation for pulmonary failure. JAMA 256: 3364–3366PubMedCrossRefGoogle Scholar
  56. 50.
    Fanta CH, Pennington JE (1981) Fever and new lung infiltrates in the immunocompromised host. Clin Chest Med 2: 19–39PubMedGoogle Scholar
  57. 51.
    Fisher DD, Armstrong D, Yu B, Gold JWM (1981) Invasive aspergillosis: prognosis in early diagnosis and treatment. Am J Med 71: 571–577PubMedCrossRefGoogle Scholar
  58. 52.
    Fishman LS, Griffin JR, Sapico FL et al. (1972) Hematogenous Candida endophthalmitis: a complication of candidemia. N Engl J Med 286: 675–681PubMedCrossRefGoogle Scholar
  59. 53.
    Ford JM, Brown LM, Cullen MH, Oliver RTD, Lister TA (1982) Prophylactic granulocyte transfusions: results of a randomised clinical trial in patients with acute myelogenous leukaemia. Transfusion 22: 498–501PubMedCrossRefGoogle Scholar
  60. 53a.
    Gabrilove JL, Jakubowski A (1990) Haemopoietic growth factors: biology and clinical application. J Nat Cancer Inst Monogr 10: 73–77Google Scholar
  61. 54.
    Garnick MB, Mayer RJ (1978) Acute renal failure associated with neoplatic disease and its treatment. Sem in Oncol 5: 155–166Google Scholar
  62. 54a.
    Gasson JC, Weisbart RH, Kaufman SE et al. (1984) Purified human granulocyte-macrophage colony stimulating factor: direct action on neutrophils. Science 226: 1339–1342PubMedCrossRefGoogle Scholar
  63. 55.
    Ginsberg SJ, Comis RL (1984) The pulmonary toxicity of antineoplastic agents. In: Perry MC, Yarbro JW (eds) Toxicity of chemotherapy. Grune & Stratton, New YorkGoogle Scholar
  64. 56.
    Girtanner RE, DeCampo T, Alleyn JN, Averette HE (1981) Routine intensive care for pelvic exenterative operations. Surg Gynaecol Obstet 153: 657–659Google Scholar
  65. 57.
    Goldiner PL, Carlon GC, Cvitkovic E et al. (1978) Factors influencing post operative morbidity and mortality in patients treated with bleomycin. Br Med J 1: 1664–1667PubMedCrossRefGoogle Scholar
  66. 58.
    Goldiner PL, Pinilla J, Turnbull A (1976) Acute respiratory failure in patients with advanced lymphoma. In: Lecker MJ (ed) Hodgkin’s disease. Wiley, New York, pp 371–376Google Scholar
  67. 59.
    Grady GF, Bennett AJE (1972) Risk of post-transfusion hepatitis in the United States: a prospective cooperative study. JAMA 220: 692–701PubMedCrossRefGoogle Scholar
  68. 60.
    Gralnick HR (1990) Hemostasis and thrombosis in acute and chronic leukaemia. In: Henderson E, Lister TA, (eds) William Dameshek and Frederick Gunz’s Leukemia, 5th edn. Saunders, Philadelphia, pp 711–731Google Scholar
  69. 61.
    Greenman RL, Goodall PT, King D (1975) Lung biopsy in immunocompromised hosts. Am J Med 59: 488–496PubMedCrossRefGoogle Scholar
  70. 62.
    Grob JP, Grundy JE, Prentice HE et al. (1987) Immune donors can protect marrow transplant recipients from severe cytomegalovirus infections. Lancet i:774–776CrossRefGoogle Scholar
  71. 62a.
    Groopman JE, Mitsuyasu RT, DeLeo MJ et al. (1987) Effect of recombinant human granulocyte-macrophage colony stimulating factor on myelopoiesis in the acquired immunodeficiency syndrome. N Eng J Med 317: 593–598CrossRefGoogle Scholar
  72. 63.
    Gross NJ (1977) Pulmonary effects of radiation therapy. Ann Int Med 86: 81–92PubMedGoogle Scholar
  73. 64.
    Guiot HFL, Van den Broek PJ, Van der Meer JWM, van Furth R (1983) Selective antimicrobial modulation of the intestinal flora of patients with acute nonlymphocytic leukaemia: a double blind placebo- controlled study. J Infect Dis 147: 615–623PubMedCrossRefGoogle Scholar
  74. 65.
    Gunther I, Kaben U, Dunker H, Brijmohan-Gunther R, Konrad H (1988) Selective decontamination of the digestive tract and fungal infection in acute leukaemia patients. Recent Results Cancer Res 108: 82–88PubMedCrossRefGoogle Scholar
  75. 66.
    Hagenbeek A, Brummelhuis HGJ, Donkers A et al. (1986) Rapid clearance of cytomegalovirus-specific IgG after repeated intravenous infusions of human immunoglobulin into allogeneic bone marrow transplant recipients. J Infect Dis 155: 897–902CrossRefGoogle Scholar
  76. 67.
    Hall R, Anderson J, Smart GA, Besser GM (1981) Fundamentals of clinical endocrinology. Pitman Medical, LondonGoogle Scholar
  77. 68.
    Haupt MH, Hutchins GM, Moore GW (1981) Ara-C lung: noncardiogenic pulmonary oedema complicating cytosine arabinoside therapy of leukaemia. Am J Med 70: 256–261PubMedCrossRefGoogle Scholar
  78. 69.
    Hauser MJ, Tabak J, Baier H (1982) Survival of patients with cancer in a medical critical care unit. Arch Intern Med 142: 527–529PubMedCrossRefGoogle Scholar
  79. 70.
    Heron EM, Gutterman JU, Mavlighit GM (1976) Effect of haematological malignancies and their treatment on host defence factors. Clin Haematol 5: 425Google Scholar
  80. 71.
    Hersmain J, Meyers JD, Thomas ED et al. (1982) The effect of granulocyte transfusion as the incidence of cytomegalovirus infection after allogenic marrow transplantation. Ann Intern Med 96: 149–152Google Scholar
  81. 72.
    Herzig RH, Herzig GP, Graw R et al. (1977) Successful granulocyte transfusion therapy for gram-negative septicemia. N Engl J Med 296: 701–705PubMedCrossRefGoogle Scholar
  82. 73.
    Hewlett RI, Archie F, Wilson AF (1977) Adult respiratory distress syndrome (ARDS) following aggressive management of extensive acute lymphoblastic leukaemia. Cancer 39: 2422–2425PubMedCrossRefGoogle Scholar
  83. 74.
    Hinds CJ, Watson JD (1985) Intensive Care. In: Shepherd JH, Monaghan JH (eds) Clinical gynaecological oncology. Blackwell, Oxford, pp 351–368Google Scholar
  84. 75.
    Hoagland CH (1984) Haematologic complications of cancer chemotherapy. In: Perry MC, Yarbro JW (eds) Toxicity of chemotherapy. Grune & Stratton, New York, pp 433–448Google Scholar
  85. 76.
    Holter AR, Fischer JE (1977) The effects of perioperative hyperalimentation on complications in patients with carcinoma and weight loss. J Surg Res 23: 31–34PubMedCrossRefGoogle Scholar
  86. 77.
    Hoye RG, Bennett SH, Geelhoed GW, Gorschboth C (1972) Fluid volume and albumin kinetics occurring with major surgery. JAMA 10: 1255–1259CrossRefGoogle Scholar
  87. 78.
    Hughes WT (1977) Pneumocystis carinii pneumonia. N Engl J Med 297: 1381–1383PubMedCrossRefGoogle Scholar
  88. 79.
    Hughes WT (1987) Pneumocystis carinii pneumonitis. N Engl J Med 317: 1021–1023PubMedCrossRefGoogle Scholar
  89. 80.
    Hughes WT, Feldman S, Aur RJA et al. (1975) Intensity of immunosuppressive therapy and the incidence of Pneumocystis carinii pneumonitis. Cancer 36: 2004–2009PubMedCrossRefGoogle Scholar
  90. 80a.
    Hurt SM, McEwen J, McKenna SP (1986) Measuring health status. Croom Helm, London, pp 163–202Google Scholar
  91. 81.
    Jehn U (1988) Managing fungal and viral infection in the immunocompromised host. Recent Results Cancer Res 108: 61–70PubMedCrossRefGoogle Scholar
  92. 82.
    Johnson MH, Gordon PW, Fitzgerald FT (1986) Stratification of prognosis in granulocytopenic patients with haematologic malignancies using the APACHE-II severity of illness score. Crit Care Med 14: 693–697PubMedCrossRefGoogle Scholar
  93. 83.
    Joshi JH, Schimpff SC, Tenney JH et al. (1984) Can antibacterial therapy be discontinued in persistantly febrile granulocytopenic cancer patients? Am J Med 76: 450–457PubMedCrossRefGoogle Scholar
  94. 84.
    Kanis JA, Yates AJP, Rüssel RGG (1986) Hypercal- caemia and skeletal complications of myeloma. In: Delaware W (ed) Multiple myeloma and other paraproteinemias. Churchill Livingstone, EdinburghGoogle Scholar
  95. 85.
    Kaplan RS, Wiernk PH (1984) Neurotoxicity of anti-tumour agents. In: Perry MC, Yarbro JW (eds) Toxicity of chemotherapy. Grune & Stratton, New York pp 365–431Google Scholar
  96. 86.
    Klastersky J (1979) Granulocyte transfusions as a therapy and a prophylaxis of infections in neutropenic patients. Eur J Cancer 15: 15–22PubMedGoogle Scholar
  97. 87.
    Klastersky J, Zinner SH, Calandra T et al. (1988) Empiric antimicrobial therapy for febrile granulocytopenic cancer patients: lessons from four EORTC trials. Eur J Clin Oncol 24: 35–45CrossRefGoogle Scholar
  98. 88.
    Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) APACHE II: a severity of disease classification system. Crit Care Med 13: 818–829PubMedCrossRefGoogle Scholar
  99. 89.
    Kovacs JA, Ng VL, Masur H et al. (1988) The diagnosis of Pneumocystis carinii pneumonia: improved detection in sputum with use of monoclonal antibodies. N Engl J Med 318: 589–593PubMedCrossRefGoogle Scholar
  100. 90.
    Krishnan EC, Menon CD, Krishnan L, Jewell WR (1980) Deficiency in maturation process of macrophages in human cancer. J Nat Cancer Inst 65: 273–276PubMedGoogle Scholar
  101. 91.
    Krowka MJ, Rosenow EC, Hoagland HC (1985) Pulmonary complications of bone marrow transplantation. Chest 87: 237–246PubMedCrossRefGoogle Scholar
  102. 92.
    Lau WK, Young LS, Black RE et al. (1977) Comparative efficacy and toxicity of amikacin/carbenicillin versus gentamicin/carbenicillin in leukopenic patients: a randomised prospective trial. Am J Med 62: 959–966PubMedCrossRefGoogle Scholar
  103. 92a.
    Lee EJ, Schiffer CA (1987) Serial measurement of lymphocytotoxic antibody and response to nonmatched platelet transfusions in alloimmunized patients. Blood 70: 1727–1729PubMedGoogle Scholar
  104. 93.
    Leight GS, Michaelis LL (1978) Open lung biopsy for the diagnosis of acute, diffuse pulmonary infiltrates in the immunosuppressed patient. Chest 73: 477–482PubMedCrossRefGoogle Scholar
  105. 94.
    Leonov Y, Golik A, Kaufman S, Gilboa Y (1987) Acute tumour lysis syndrome with extreme metabolic abnormalities. Clin Lab Haematol 9: 85–89PubMedGoogle Scholar
  106. 95.
    Levine AS, Schimpff SC, Graw RG Jr et al. (1974) Hematological malignancies and other marrow failure states: progress in the management of complicating infections. Semin Hematol 11: 141–203PubMedGoogle Scholar
  107. 96.
    Levy R, Kaplan HS (1974) Impaired lymphocyte function in untreated Hodgkin’s disease. N Engl J Med 290: 181–186PubMedCrossRefGoogle Scholar
  108. 97.
    Lishner M, Pomeranz A, Rozenbajm E, Korets Z, Srenkman L (1987) Hypercalcaemia induced acute renal failure as presenting feature of T cell leukaemia. Eur J Paediatr 146: 68–69CrossRefGoogle Scholar
  109. 98.
    Lisiewicz J (1978) Mechanism of haemorrhage in leukaemias. Semin Thromb Hemost 4: 241–267PubMedGoogle Scholar
  110. 99.
    Lister TA, Rohatiner AZS (1982) The treatment of acute myelogenous leukaemia in adults. Semin hematol 19: 172–191PubMedGoogle Scholar
  111. 100.
    Lloyd-Thomas AR, Dhaliwal HS, Lister TA, Hinds CJ (1986) Intensive therapy for life-threatening medical complications of haematological malignancy. Intensive Care Med 12: 317–324PubMedCrossRefGoogle Scholar
  112. 101.
    Lloyd-Thomas AR, Wright I, Lister TA, Hinds CJ (1988) Prognosis of patients receiving intensive care for life threatening medical complications of haematological malignancy. Br Med J 296: 1025–1029CrossRefGoogle Scholar
  113. 102.
    Lundy J, Sherlock P, Kurtz R, Fortner JG, Turnbull AD (1975) Spontaneous perforation of the gastrointestinal tract in patients with cancer. Am J Gastroenterol 63: 447–450PubMedGoogle Scholar
  114. 103.
    Markman M, Abeloff MD (1983) Management of hematologic and infectious complications of intensive induction therapy for small cell carcinoma of the lung. Am J Med 74: 741–746PubMedCrossRefGoogle Scholar
  115. 104.
    Mattay RA, Farmer WC, Odero D (1977) Diagnostic fibreoptic bronchoscopy in the immunocompromised host with pulmonary infiltrates. Thorax 32: 539–545CrossRefGoogle Scholar
  116. 105.
    Matthews RC, Burnie JP (1988) A prospective assessment of a reverse passive latex agglutination test in the serodiagnosis of systemic candidosis. Serodiagn Immunother Infect Dis 2: 95–101CrossRefGoogle Scholar
  117. 106.
    McCabe RE, Brooks RG, Mark JBD, Remington JS (1985) Open lung biopsy in patients with acute leukaemia. Am J Med 78: 609–616PubMedCrossRefGoogle Scholar
  118. 107.
    Meguid MM, Meguid V (1985) Preoperative identification of the surgical cancer patient in need of postoperative supportive total parenteral nutrition. Cancer 55: 258–262PubMedCrossRefGoogle Scholar
  119. 108.
    Merritt JA, Entracher MS (1985) The acute leukemias. In: Rippe JM, Irwin RS, Alpert JS, Dalen JE (eds) Intensive care medicine. Little, Brown & Co, Boston, pp 853–858Google Scholar
  120. 108a.
    Metealf D, Begley CG, Johnson GR et al. (1986) Biological properties in vitro of a recombinant human granulocyte-macrophage colony stimulating factor. Blood 67: 37–45Google Scholar
  121. 109.
    Meuwissen JH, Tauber I, Leeuwenberg ADEM et al. (1977) Parasitologic and serological observations of infection with Pneumocystis in humans. J Infect Dis 136: 43–49PubMedCrossRefGoogle Scholar
  122. 110.
    Meyers JD, Flournoy N, Thomas ED (1986) Risk factors for cytomegalovirus infection after human marrow transplantation. J Infect Dis 153: 478–488PubMedCrossRefGoogle Scholar
  123. 111.
    Milburn HL, Prentice HG, Du Bois RM (1987) Role of bronchoalveolar lavage in the evaluation on interstitial pneumonitis in recipients of bone marrow transplants. Thorax 42: 766–772PubMedCrossRefGoogle Scholar
  124. 112.
    Mitchell EP, Schein PS (1984) Gastrointestinal toxicity of chemotherapeutic agents. In: Perry MC, Yarbro JW (eds) Toxicity of chemotherapy. Grune & Stratton, New York pp 269–295Google Scholar
  125. 113.
    Möhler JL, Flanigan RC (1987) The effect of nutritional status and support on morbidity and mortality of bladder cancer patients treated by radical cystectomy. J Urol 137: 404–407PubMedGoogle Scholar
  126. 114.
    Morrison HM, Stockley RA (1988) The many uses of bronchoalveolar lavage. Br Med J 296: 1758CrossRefGoogle Scholar
  127. 115.
    Morton AR, Cantrill JA, Craig AE et al. (1988) Single dose versus daily intravenous amino-hydroxypropylidene biphosphonate (APD) for the hypercalcaemia of malignancy. Br Med J 296: 811–814CrossRefGoogle Scholar
  128. 116.
    Muller JM, Brenner U, Dienst C, Pichlmaier H (1982) Preoperative parenteral feeding in patients with gastrointestinal carcinoma. Lancet i:68CrossRefGoogle Scholar
  129. 117.
    Mundy GR, Martin TJ (1982) The hypercalaemia of malignancy: pathogenesis and management. Metabolism 31: 1247–1277PubMedCrossRefGoogle Scholar
  130. 118.
    Nauseff WM, Maki DG (1983) A study of the value of simple protective isolation in patients with granulocytopenia. N Engl J Med 304: 448–453CrossRefGoogle Scholar
  131. 119.
    Nedelkova M, Bacalova S, Georgieva B (1981) Infectious complications and host immune defence in acute leukaemia. Eur J Cancer 17: 617–622PubMedGoogle Scholar
  132. 120.
    Neiman PR, Reeves W, Ray G et al. (1977) A prospective analysis of interstitial pneumonia and opportunistic viral infection among recipients of allogenic bone marrow grafts. J Infect Dis 136: 754–767PubMedCrossRefGoogle Scholar
  133. 120a.
    Nemunaitis J, Singer JW, Buckner CD et al. (1988) Use of recombinant human granulocyte-macrophage colony stimulating factor in autologous bone marrow transplantation for lymphoid malignancies. Blood 72: 834–836PubMedGoogle Scholar
  134. 121.
    Nieto AF, Dofy DB (1986) Superior vena cava obstruction: clinical syndrome, aetiology and history. Curr Probl Cancer 10: 441–484PubMedCrossRefGoogle Scholar
  135. 122.
    Ognibene FP, Martin SE, Parker MM et al (1986) Adult respiratory distress syndrome in patients with severe neutropenia. N Engl J Med 315: 547–551PubMedCrossRefGoogle Scholar
  136. 123.
    Orr JW, Shingleton HM, Soong SJ et al. (1983) Hemodynamic parameters following pelvic exenteration. Am J Obstet Gynecol 146: 822–892Google Scholar
  137. 123a.
    Patrick DL, Davis M, Southerland LI et al. (1988) Quality of life following intensive care. J Gen Int Med 3: 218–223CrossRefGoogle Scholar
  138. 124.
    Pennington JE, Feldman NT (1977) Pulmonary infiltrates and fever in patients with hematologic malignancy: assessment of transbronchial biopsy. Am J Med 62: 581–587PubMedCrossRefGoogle Scholar
  139. 125.
    Pennington JE, Reynolds HY, Carbone PP (1973) Pseudomonas pneumonia: a restrospective study of 36 cases. Am J Med 55: 155–160PubMedCrossRefGoogle Scholar
  140. 126.
    Pennington JE, Small GJ (1987) Passive immune therapy for experimental Pseudomonas aeruginosa pneumonia in the neutropenic host. J Infect Dis 155: 973–978PubMedCrossRefGoogle Scholar
  141. 127.
    Perry MC (1984) Hepatotoxicity of chemotherapeutic agents. In: Perry MC, Yarbro JW (eds) Toxicity of chemotherapy. Grune & Stratton, New York, pp 297–315Google Scholar
  142. 128.
    Peters SG, Meadows JA, Gracey DR (1988) Outcome of respiratory failure in haematologic malignancy. Chest 94: 99–102PubMedCrossRefGoogle Scholar
  143. 129.
    Pizzo PA (1984) Granulocytopenia and cancer therapy: past problems, current solutions, future challenges. Cancer 54: 2649–2661PubMedCrossRefGoogle Scholar
  144. 130.
    Pizzo PA, Robinchaud KJ, Gill FA et al. (1979) Duration of empiric antibiotic therapy in granulocytopenic cancer patients. Am J Med 67: 194–200PubMedCrossRefGoogle Scholar
  145. 131.
    Pizzo PA, Robinchaud KJ, Gill FA et al. (1982) Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia. Am J Med 72: 101–111PubMedCrossRefGoogle Scholar
  146. 132.
    Pizzo PA, Robinchaud KJ, Wesley R et al. (1982) Fever in the paediatric and young adult patient with cancer. Medicine 61: 153–165PubMedCrossRefGoogle Scholar
  147. 133.
    Poe RH, Wahl GW, Qazi R et al. (1986) Predictors of mortality in the immunocompromised patient with pulmonary infiltrates. Arch Intern Med 146: 1304–1308PubMedCrossRefGoogle Scholar
  148. 134.
    Preisler HD, Hasenclever HF, Henderson ES (1971) Anti-Candida antibodies in patients with acute leukaemia: a prospective study. Am J Med 51: 352–361PubMedCrossRefGoogle Scholar
  149. 135.
    Press OW, Livingston R (1987) Management of malignant pericardial effusion and tamponade. JAMA 257: 1088–1092PubMedCrossRefGoogle Scholar
  150. 136.
    Price FW (ed) (1937) A textbook of the practice of medicine. Oxford University Press, OxfordGoogle Scholar
  151. 137.
    Reed EC, Bowden RA, Dandliker PS et al. (1987) Efficacy of cytomegalovirus immunoglobulin in marrow transplant recipients with cytomegalovirus pneumonia. J Infect Dis 156: 641–645PubMedCrossRefGoogle Scholar
  152. 138.
    Remington JS, Schimpff SC (1981) Please do not eat the salads. N Eng J Med 304: 433–435CrossRefGoogle Scholar
  153. 139.
    Rinaldo JE, Borovetz H (1985) Deterioration of oxygen-ation and abnormal lung microvascular permeability during resolution of leukopenia in patients with diffuse lung injury. Am Rev Respir Dis 131: 579–583PubMedGoogle Scholar
  154. 140.
    Rohatiner AZS, Gregory WM, Barnett MJ et al. (1988) Short term therapy for acute myelogenous leukaemia. J Clin Oncol 6: 218–226PubMedGoogle Scholar
  155. 141.
    Romainis WHC, Mitchiner PH (1937) The science and practice of surgery volume 1. Churchill, LondonGoogle Scholar
  156. 142.
    Rosch J, Bedell JE, Putnam J et al. (1987) Gianturco expandable wire stents in the treatment of superior vena cava syndrome recurring after maximum-tolerance radiotherapy. Cancer 60: 1243–1246PubMedCrossRefGoogle Scholar
  157. 143.
    Rosenheim MS, Farewell VT, Price TH et al. (1980) The cost effectiveness of therapeutic and prophylactic leukocyte transfusion. N Eng J Med 302: 1058–1062CrossRefGoogle Scholar
  158. 144.
    Rosenthal N, Insogna KL, Godsall JW et al. (1985) Elevations in circulating 1,25-dihydroxy vitamin D in three patients with lymphoma-associated hypercalcaemia. J Clin Endocrinol Metab 60: 29–33PubMedCrossRefGoogle Scholar
  159. 145.
    Rossiter SJ, Mille DC, Churg AM et al. (1979) Open lung biopsy in the immunosuppressed patient: is it really beneficial? J Thorac Cardiovasc Surg 77: 338–343PubMedGoogle Scholar
  160. 146.
    Rubinstein LJ, Herman MM, Long TF, Wilbur JR (1975) Disseminated necrotizing leukoencephalopathy: a complication of treated central nervous system leukaemia and lymphoma. Cancer 35: 291–305PubMedCrossRefGoogle Scholar
  161. 147.
    Sallerfors B, Gale RP (1987) A critical analysis of acute graft-versus-host disease in twins. In: Gale RP, Champlin R (eds) Prognosis in bone marrow transplantation. Liss, New York pp 281–293Google Scholar
  162. 148.
    Santosham M, Reid R, Ambrosino DM et al. (1987) Prevention of Haemophilus influenzae type B infections in high risk infants treated with bacterial polysaccharide immune globulin. N Engl J Med 317: 923–929PubMedCrossRefGoogle Scholar
  163. 149.
    Saral R, Burns W, Laskin OL, Santos GW, Lietman PS (1981) Acyclovir prophylaxis of herpes-simplex-virus infections. N Engl J Med 305: 63–67PubMedCrossRefGoogle Scholar
  164. 150.
    Saravolatz LD, Burch KH, Fisher E et al. (1979) The compromised host and Legionnaires disease. Ann Intern Med 90: 533–537PubMedGoogle Scholar
  165. 151.
    Satler LF, Rackley CE (1986) The medical emergency of cardiac tamponade: recognition and management. Cardiovasc Clin 16: 181–189PubMedGoogle Scholar
  166. 152.
    Satterfield JR, McLaughlin JS (1979) Open lung biopsy in diagnosing infiltrates in immunosuppressed patients. Ann Thorac Surg 28: 359–362PubMedCrossRefGoogle Scholar
  167. 153.
    Scher HI, Yagoda A (1987) Bone metastases: pathogenesis, treatment and rationale for use of resorption inhibitors. Am J Med 82: 6–28PubMedCrossRefGoogle Scholar
  168. 154.
    Schiffer CA, Aisner J, Daly PA et al. (1979) Alloimmunization following prophylactic granulocyte transfusion. Blood 54: 766–774PubMedGoogle Scholar
  169. 155.
    Schilsky RL (1984) Renal and metabolic toxicities of cancer treatment. In: Perry MC, Yarbro JW (eds) Toxicity of chemotherapy. Grune & Stratton, New York pp 317–342Google Scholar
  170. 156.
    Schimpff SC (1989) Infection in the leukaemia patient: diagnosis, therapy and prevention. In: Henderson E, Lister TA (eds) William Dameshek and Frederick Gunz’s Leukemia, 5th edn. Saunders, Philadelphia, pp 687–709Google Scholar
  171. 157.
    Schimpff SC, Greene WH, Young VM et al. (1975) Infection prevention in acute nonlymphocytic leukaemia: laminar air flow room reverse isolation with oral, non-absorbable antibiotic prophylaxis. Ann Intern Med 82: 351–358PubMedGoogle Scholar
  172. 158.
    Schimpff SC, Young VM, Greene WH et al. (1972) Origin of infection in acute nonlymphocytic leukemia: significance of hospital acquisition of potential pathogens. Ann Intern Med 77: 707–711PubMedGoogle Scholar
  173. 159.
    Schuster DP, Marion JM (1983) Precedents for meaningful recovery during treatment in a medical intensive care unit: outcome in patients with hematological malignancy. Am J Med 75: 402–408PubMedCrossRefGoogle Scholar
  174. 160.
    Scott RB (1957) Leukaemia. Lancet i:1053–1058Google Scholar
  175. 161.
    Sculier JP, Bron D, Verboven M, Klastersky J (1988) Multiple organ failure during interleukin-2 administration and LAK cells infusion. Intensive Care Med 14: 666–667PubMedCrossRefGoogle Scholar
  176. 162.
    Sculier JP, Ries F, Verboven N, Coune E, Klatersky] (1988) Role of intensive care unit in a medical oncology department. Eur J Cancer Clin Oncol 24: 513–517Google Scholar
  177. 163.
    Sherwood LM (1980) The multiple causes of hypercalcaemia in malignant disease. N Eng J Med 303: 1412–1413CrossRefGoogle Scholar
  178. 164.
    Shoemaker WC, Appel PL, Bland R, Hopkins JA, Change P (1982) Clinical trial of an algorithm for outcome prediction in acute circulatory failure. Crit Care Med 10: 390–397PubMedCrossRefGoogle Scholar
  179. 165.
    Shoemaker WC, Appel PL, Waxman K et al. (1982) Clinical trial of survivors’ cardiorespiratory patterns as therapeutic goals in critically ill postoperative patients. Crit Care Med 10: 398–403PubMedCrossRefGoogle Scholar
  180. 165a.
    Shoemaker WC, Appel P, Kram H et al. (1988) Prospective trial of supranormal values of survivors as therapeutic goals in high risk surgical patients. Chest 94: 1176–1186PubMedCrossRefGoogle Scholar
  181. 166.
    Sickles EA, Greene WH, Wiernik PH (1975) Clinical presentation of infection in granulocytopenic patients. Arch Intern Med 135: 715–719PubMedCrossRefGoogle Scholar
  182. 167.
    Sickles EA, Young VM, Greene WH et al. (1973) Pneumonia in acute leukaemia. Ann Intern Med 79: 528–534PubMedGoogle Scholar
  183. 168.
    Siegal T, Siegal T (1987) Treatment of metastatic epidural cord compression: state of the art. In: Lapis K, Eckhardt S (eds) UICC 14th international cancer congress, Budapest: Radiotherapy, Paediatric Oncology, Neurooncology, pp 329–336Google Scholar
  184. 169.
    Singer C, Armstrong D, Rosen PP et al. (1975) Pneumocystis Carinii pneumonia: a cluster of eleven cases. Ann Intern Med 82: 722–777Google Scholar
  185. 170.
    Singer C, Armstrong D, Rosen PP, Walzer PD, Yu B (1979) Diffuse pulmonary infiltrates in immuno-suppressed patients: Prospective study of 80 cases. Am J Med 6: 110–120CrossRefGoogle Scholar
  186. 171.
    Singer FR, Fernandez M (1987) Therapy of hyper-calcaemia of malignancy. Am J Med 82: 34–41PubMedCrossRefGoogle Scholar
  187. 172.
    Slevin ML, Cotterill AM, Bell R, Lister TA (1981) The “tumour overkill syndrome”: a potentially lethal complication of cancer chemotherapy. Postgrad Med J 57: 727–729PubMedCrossRefGoogle Scholar
  188. 173.
    Slevin ML, Knowles GK, Phillips HJ, Stansfeld AG, Lister TA (1982) The air crescent sign of invasive pulmonary aspergillosis in acute leukaemia. Thorax 37: 554–5PubMedCrossRefGoogle Scholar
  189. 174.
    Smith CR, Lipsky JJ, Laskin OL et al. (1980) Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin. N Engl J Med 302: 1106–1109PubMedCrossRefGoogle Scholar
  190. 175.
    Snow RM, Miller WC, Rice DL, Ali MK (1979) Respiratory failure in cancer patients. JAMA 241: 2039–2042PubMedCrossRefGoogle Scholar
  191. 176.
    Solomon MJ, Smith MF, Dowd JB, Bistrian BR, Blackburn GL (1978) Optimal nutritional support in surgery for bladder cancer: preservation of visceral protein by amino acid infusions. J Urol 119: 350–354PubMedGoogle Scholar
  192. 177.
    Springmeyer SC, Silverstri RC, Sale GE et al. (1982) The role of transbronchial biopsy for the diagnosis of diffuse pneumonias in immunocompromised marrow transplant recipients. Am Rev Resp Dis 126: 763–765PubMedGoogle Scholar
  193. 178.
    Strauss RG, Connett JE, Gale RP et al. (1981) A controlled trial of prophylactic granulocyte transfusions during initial induction chemotherapy for acute myelogenous leukaemia. N Engl J Med 305: 597–603PubMedCrossRefGoogle Scholar
  194. 179.
    Tenholder MF, Hooper RG (1980) Pulmonary infiltrates in leukaemia. Chest 78: 468–473PubMedCrossRefGoogle Scholar
  195. 180.
    Theologides A (1978) Neoplastic cardiac tamponade. Semin Oncol 5: 181–192PubMedGoogle Scholar
  196. 181.
    Thomas F, Burke JP, Parker J et al. (1983) The risk of infection related to radial versus femoral sites for arterial catheterization. Crit Care Med 11: 807–812PubMedCrossRefGoogle Scholar
  197. 182.
    Thompson BR, Julian TB, Streple JF (1981) Perioperative total parenteral nutrition in patients with gastrointestinal cancer. J Surg Res 30: 497–500PubMedCrossRefGoogle Scholar
  198. 183.
    Tokaz LK, Von Hoff DD (1984) The cardiotoxicity of anticancer drugs. In: Perry MC, Yarbro JW (eds) Toxicity of chemotherapy. Grune & Stratton, New YorkGoogle Scholar
  199. 184.
    Torrecilla C, Cortes JL, Chamorro C, Rubio JJ, Galdos P, De Villota ED (1988) Prognostic assessment of the acute complications of bone marrow transplantation requiring intensive therapy. Intensive Care Med 14: 393–398PubMedCrossRefGoogle Scholar
  200. 185.
    Turnbull AD, Goldiner P, Silverman D, Howland W (1976) The role of an intensive care unit in a cancer centre. Cancer 37: 82–84PubMedCrossRefGoogle Scholar
  201. 186.
    Turnbull AD, Carlon GC, Baron R, Sichel W, Young C, Howland W (1979) The inverse relationship between cost and survival in the critically ill cancer patient. Crit Care Med 7: 20–23PubMedCrossRefGoogle Scholar
  202. 186a.
    Vadhan-Raj S, Keating M, LeMaistre A et al. (1987) Effects of recombinant human granulocyte-macrophage colony stimulating factor in patients with myelo-dysplastic syndromes. N Eng J Med 317: 1545–1552CrossRefGoogle Scholar
  203. 187.
    Valdivieso M, Gil-Extremera B, Zornoza J et al. (1977) Gram-negative bacillary pneumonia in the compromised host. Medicine 56: 241–254PubMedCrossRefGoogle Scholar
  204. 188.
    Van Belle SJP, Volkaert A, Taeymans Y, Spapen H, Block P (1987) Treatment of malignant pericardial tamponade with sclerosis induced by instillation of bleomycin. Int J Cardiol 16: 155–160PubMedCrossRefGoogle Scholar
  205. 189.
    Van Der Waaij D (1988) Selective decontamination of the digestive tract: general principles. Eur J Clin Oncol 24 (Suppl 1): S1–S4CrossRefGoogle Scholar
  206. 190.
    Van Ness MM, Cattau EL (1987) Fulminant colitis complicating antibiotic associated pseudoembraneous colitis. Am J Gastroenterol 82: 374–377PubMedGoogle Scholar
  207. 191.
    Vernant JP, Brun B, Mannoni P, Dreyfus B (1979) Respiratory distress of hyperleukocytic granulocytic leukemias. Cancer 44: 264–268PubMedCrossRefGoogle Scholar
  208. 192.
    Wardman AG, Cooke NJ (1984) Pulmonary infiltrates in adult acute leukaemia: empirical treatment or lung biopsy? Thorax 34: 647–650CrossRefGoogle Scholar
  209. 193.
    Willson JKV (1978) Pulmonary toxicity of antineoplastic drugs. Cancer Treatment Rep 62: 2003–2008Google Scholar
  210. 194.
    Wimberley N, Faling LJ, Bartlett JG (1979) A fibreoptic bronchoscopy technique to obtain uncontaminated lower airway secretions for bacterial culture. Am Rev Resp Dis 119: 337–343PubMedGoogle Scholar
  211. 195.
    Winston DJ, Ho WG, Howell CL et al. (1980) Cytomegaloviruses associated with leukocyte transfusions. Ann Intern Med 93: 671–675PubMedGoogle Scholar
  212. 196.
    Winston DJ, Ho WG, Gale RP (1981) Prophylactic granulocyte transfusions during chemotherapy of acute non lymphocytic leukaemia. Ann Intern Med 94: 616–622PubMedGoogle Scholar
  213. 197.
    Winston DJ, Ho WG, Gale RP (1982) Therapeutic granulocyte transfusions for documented infections. Ann Intern Med 97: 509–515PubMedGoogle Scholar
  214. 198.
    Winston DJ, Ho WG, Lin CH et al. (1987) Intravenous immune globulin for prevention of cytomegalovirus infection and interstitial pneumonia after bone marrow transplantation. Ann Intern Med 106: 12–18PubMedGoogle Scholar
  215. 199.
    Winston DJ, Ho WG, Gale RP, Champlin RE (1988) Prophylaxis on infections in bone marrow transplants. Eur J Clin Oncol 24: 15–23CrossRefGoogle Scholar
  216. 200.
    Witherspoon RP, Sterb R, Ochs HD et al. (1981) Recovery of antibody production in human allogenic marrow graft recipients, influence of time post transplantation: the presence or absence of chronic graft-versus-host disease and antithymocyte globulin treatment. Blood 58: 360–368PubMedGoogle Scholar
  217. 201.
    Wright DG, Robinchaud KJ, Pizzo PA, Deisseroth AB (1981) Lethal pulmonary reactions associated with the combined use of amphotericin B and leukocyte transfusions. N Engl J Med 304: 1185–1189PubMedCrossRefGoogle Scholar
  218. 202.
    Young LS, Meyer RD, Armstrong D (1973) Pseudomonas aeruginosa vaccine in cancer patients. Ann Intern Med 79: 518–522PubMedGoogle Scholar
  219. 202a.
    Zigmond AS, Smith RP (1983) The Hospital Anxiety and Depression Scale. Acta Psychiatr Scand 67: 361–370PubMedCrossRefGoogle Scholar
  220. 203.
    Zusman J, Brown DM, Nesbit ME (1973) Hyperphosphatemia, hyperphosphaturia and hypocalcaemia in acute lymphoblastic leukaemia. N Eng J Med 289: 1335–1340CrossRefGoogle Scholar

Copyright information

© Springer-Verlag London Limited 1992

Authors and Affiliations

  • C. J. Hinds
  • A. M. Oza

There are no affiliations available

Personalised recommendations