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Occlusive Arterial Disease and Blood Rheology

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Clinical Aspects of Blood Viscosity and Cell Deformability

Abstract

A variety of common and important clinical events are thought to arise from organ ischaemia secondary to obstructed blood flow in the major arteries which supply the heart, brain and lower limbs. It is our purpose to review the possible contribution of blood rheology to these events. Recent interest in this topic probably arises for three reasons. In the last decade a number of studies have been reported which associate blood rheology factors with clinical arterial events, not only retrospectively but also prospectively. Secondly, changes in blood viscosity and its major determinants (haematocrit, plasma viscosity, plasma fibrinogen level) have been related to changes in cerebral and limb blood flow in man. Thirdly, alteration of the flow properties of blood appears to be a possible therapeutic approach to problems against which we currently have a very limited armamentarium. Most patients with angina pectoris obtain some relief from glyceryl trinitrate and beta-adrenergic blocking drugs, and arterial reconstructive surgery also gives symptomatic improvement to selected subjects who have angina or transient symptoms of leg or brain ischaemia. There is, however, little evidence that any medical or surgical measures alter the natural history of occlusive arterial disease — with the exception of stopping cigarette-smoking (Doll and Hill, 1964).

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Authors
  1. G. D. O. Lowe
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  2. M. M. Drummond
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  3. C. D. Forbes
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  4. J. C. Barbenel
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Editors and Affiliations

  1. University Department of Medicine, Royal Infirmary, 86 Castle Street, G4 0SF, Glasgow, Scotland

    G. D. O. Lowe MB, ChB, MRCP (Lecturer in Medicine and Honorary Senior Registrar) & C. D. Forbes MD, FRCP (Senior Lecturer in Medicine and Honorary Consultant Physician) (Lecturer in Medicine and Honorary Senior Registrar) &  (Senior Lecturer in Medicine and Honorary Consultant Physician)

  2. Bioengineering Unit, University of Strathclyde, G4 0NW, Glasgow, Scotland

    J. C. Barbenel BDS, BSc, MSc, PhD, LDS, RCS, MInstP (Senior Lecturer) (Senior Lecturer)

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Lowe, G.D.O., Drummond, M.M., Forbes, C.D., Barbenel, J.C. (1981). Occlusive Arterial Disease and Blood Rheology. In: Lowe, G.D.O., Barbenel, J.C., Forbes, C.D. (eds) Clinical Aspects of Blood Viscosity and Cell Deformability. Springer, London. https://doi.org/10.1007/978-1-4471-3105-2_13

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  • DOI: https://doi.org/10.1007/978-1-4471-3105-2_13

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