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Regulation of Osteogenesis

  • J. M. Connor
Chapter

Abstract

Normally production of bone is restricted to the skeleton. The mechanisms which ensure this are not understood, but insight should be gained by the study of pathological situations in which soft tissue ossification occurs. Similarly, a knowledge of the mechanisms which are concerned with the regulation of normal osteogenesis will no doubt aid understanding of abnormal osteogenesis. In the production of both normal and ectopic bone the initial step is the synthesis of a highly ordered organic matrix. Subsequently this becomes mineralized. Control mechanisms may operate at all stages in this process but are likely to be involved in the initial phases of matrix production. Furthermore, therapy which aims to prevent the formation of ectopic bone needs to prevent this initial matrix synthesis. For these reasons this chapter will concentrate on the factors which can influence the synthetic aspects of bone matrix homeostasis, after briefly considering the origins of osteogenic cells and the normal requirements for ossification.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • J. M. Connor
    • 1
  1. 1.Duncan Guthrie Institute of Medical GeneticsYorkhill, GlasgowScotland

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