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DNA in human cells is continuously subject to damage. It is in most cases appropriately repaired, leaving relatively few permanent changes. The various kinds of damage comprise chemical modification or loss of DNA bases, single strand or double strand breaks as well as intra- and interstrand crosslinks. Each type of damage can lead to mutations. An important source of mutations are DNA replication and recombination. DNA replication is a particular critical phase, during which misincorporation of nucleotides, DNA polymerase slippage or stalling of replication forks may occur. A further source of mutations are physiological recombination processes that go astray, e.g. in germ cells or lymphocytes.

Keywords

Mismatch Repair Nucleotide Excision Repair Fanconi Anemia Xeroderma Pigmentosum Homologous Recombination Repair 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer 2007

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