Epithelial Repair and Regeneration

  • Steven L. Brody
  • Jeffrey J. Atkinson
Part of the Molecular Pathology Library book series (MPLB, volume 1)


Contact with the environment positions the respiratory epithelium at risk for acute and chronic injury from infectious pathogens, noxious agents, and inflammatory processes. Thus, to protect gas transfer within the lung the epithelium is programmed for routine maintenance and repair. Programs for repair are directed by epithelial, mesenchymal, and inflammatory signals that collectively constitute highly regulated networks. Principal components of the repair network are developmental morphogens, integrin and growth factor signaling molecules, and transcription factors. The epithelium responds to these signals with a remarkable plasticity and is bulwarked by a population of lung progenitor cells to ensure maintenance and repair for fluid balance and host defense functions.


Hepatocyte Growth Factor Acute Lung Injury Airway Epithelial Cell Alveolar Epithelial Cell Keratinocyte Growth Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC. 2008

Authors and Affiliations

  • Steven L. Brody
    • 1
  • Jeffrey J. Atkinson
    • 2
  1. 1.Division of Pulmonary and Critical Care Medicine, Department of Internal MedicineWashington University School of MedicineSt. LouisUSA
  2. 2.Department of Internal Medicine/Pulmonary and Critical CareWashington University School of MedicineSt. LouisUSA

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