Vaccine Containing Natural TLR Ligands Protects from Salmonella typhimurium Infection in Mice and Acute Respiratory Infections in Children

  • Boris SemenovEmail author
  • Vitaly Zverev
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 601)


It has been shown that a single parenteral administration of vaccine containing bacterial ligands for TLR1, TLR2, TLR4, TLR6, and TLR9 in mice induced rapid (24 h after administration) and effective (100%), but short-term (96 h) protection against lethal challenge with Salmonella typhimurium. Repeated mucosal applications of this vaccine stimulated long-term (up to 9 months) protection against acute respiratory infections in children of preschool age.


Innate Immunity Avian Influenza Avian Influenza Virus Acute Respiratory Infection Lethal Challenge 
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  1. Alibek, K. and Lobanova, K. (2006) Modulation of innate immunity to protect against biological weapon threat. In: B. Anderson, H. Fridman and M. Bendinelli (Eds.), Microorganisms and Bioterrorism. Springer Science Business Media, N.Y., N.Y. USA, pp. 39–61.CrossRefGoogle Scholar
  2. Balabolkin, I.I., Stepushina, M.A., Egorova, N.B., Krasnoproshina, L.I., Kurbatova, E.A., Skhodova, S.A. and Katosova, L.K. (1998) Use of polycomponent bacterial vaccine for treatment of asthma in children. Int. J. Immunorehabil. (Russ.) 10, 158–164.Google Scholar
  3. Hackett, C.J. (2003) Innate immune activation as a broad-spectrum biodefence strategy: prospects and research challenges. J. Allergy Clin. Immunol. 112, 686–694.CrossRefPubMedGoogle Scholar
  4. Ison, M.G., Mills, J., Openshaw, P., Zambon, M., Osterhaus, A. and Hayden, F. (2002) Current research on respiratory viral infections: Fourth International Symposium. Antivir. Res. 55, 227–278.CrossRefPubMedGoogle Scholar
  5. Semenov, B.F., Egorova, N.B., Semenova, I.B. and Kurbatova, E.A. (2000) Therapeutic vaccines. Ros. Med. Vestn. (Russ.)3, 26–32.Google Scholar
  6. Semenov, B.F. and Zverev, V.V. (2007) Concept of inducing of rapid immunological protection against pathogens. Zhurn. Microbiol. (Moscow), 4 (in press).Google Scholar
  7. Sergiev, V.P., Malyshev, M.A. and Drynov, I.D. (2000) Evolution of Infectious Diseases. Nauka, Moscow (in Russian).Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  1. 1.Mechnikov Research Institute of Vaccines and SeraMoscowRussia

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