Viral Infections of the Lung

  • Sherif R. Zaki
  • Christopher D. Paddock


The lungs are among the most vulnerable to microbial assault of all organs in the body. From a contemporary vantage, lower respiratory tract infections are the greatest cause of infection-related mortality in the United States, and rank seventh among all causes of deaths in the United States.2,3 From a global and historic perspective, the scope and scale of lower respiratory tract infection is greater than any other infectious syndrome, and viral pneumonias have proven to be some of the most lethal and dramatic of human diseases. The 1918–1919 influenza pandemic, perhaps the most devastating infectious disease pandemic in recorded history, resulted in an estimated 40 million deaths worldwide, including 700,000 deaths in the U.S.4 The global outbreak of severe acute respiratory syndrome (SARS) during 2003, although considerably smaller in scale, resulted in 8098 cases and 774 deaths5 and is a dramatic contemporary example of the ability of viral pneumonias to rapidly disseminate and cause severe disease in human populations.


Respiratory Syncytial Virus Severe Acute Respiratory Syndrome Measle Virus Hemorrhagic Fever Hemorrhagic Fever With Renal Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Osler W. The principles and practice of medicine. 4th ed. New York: D. Appleton, 1901.Google Scholar
  2. 2.
    Perkins BA, Flood JM, Danila R, et al. Unexplained deaths due to possibly infectious causes in the United States: defining the problem and designing surveillance and laboratory approaches. The Unexplained Deaths Working Group. Emerg Infect Dis 1996;2(1):47–53.PubMedGoogle Scholar
  3. 3.
    Hoyert DL, Kung HC, Smith BL. Deaths: preliminary data for 2003. Natl Vital Stat Rep 2005;53(15):1–48.Google Scholar
  4. 4.
    Reid AH, Taubenberger JK. The origin of the 1918 pandemic influenza virus: a continuing enigma. J Gen Virol 2003;84(pt 9):2285–2292.PubMedGoogle Scholar
  5. 5.
    Update: Outbreak of severe acute respiratory syndrome—worldwide, 2003. MMWR Morb Mortal Wkly Rep 2003;52(12):241–246, 248.Google Scholar
  6. 6.
    Greenberg SB. Viral pneumonia. Infect Dis Clin North Am 1991;5(3):603–621.PubMedGoogle Scholar
  7. 7.
    Ortqvist A, Hedlund J, Grillner L, et al. Aetiology, outcome and prognostic factors in community-acquired pneumonia requiring hospitalization. Eur Respir J 1990;3(10):1105–1113.PubMedGoogle Scholar
  8. 8.
    Macfarlane JT, Finch RG, Ward MJ, Macrae AD. Hospital study of adult community-acquired pneumonia. Lancet 1982;2(8292):255–258.PubMedGoogle Scholar
  9. 9.
    Sullivan RJ Jr, Dowdle WR, Marine WM, Hierholzer JC. Adult pneumonia in a general hospital. Etiology and host risk factors. Arch Intern Med 1972;129(6):935–942.PubMedGoogle Scholar
  10. 10.
    Woodhead MA, Macfarlane JT, McCracken JS, Rose DH, Finch RG. Prospective study of the aetiology and outcome of pneumonia in the community. Lancet 1987;1(8534):671–674.PubMedGoogle Scholar
  11. 11.
    Fekety FR Jr, Caldwell J, Gump D, et al. Bacteria, viruses, and mycoplasmas in acute pneumonia in adults. Am Rev Respir Dis 1971;104(4):499–507.PubMedGoogle Scholar
  12. 12.
    de Roux A, Marcos MA, Garcia E, et al. Viral community-acquired pneumonia in nonimmunocompromised adults. Chest 2004;125(4):1343–1351.PubMedGoogle Scholar
  13. 13.
    Ksiazek TG, Erdman D, Goldsmith CS, et al. A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med 2003;348(20):1953–1966.PubMedGoogle Scholar
  14. 14.
    Bartlett J. Approach to the patient with pneumonia. In: Gorbach SL, Bartlett JG, Blacklow NR, ed. Infectious disease. 3rd ed. Philadelphia: Lippincott Williams & Wilkins, 2004:470–479.Google Scholar
  15. 15.
    Beadling C, Slifka MK. How do viral infections predispose patients to bacterial infections? Curr Opin Infect Dis 2004;17(3):185–191.PubMedGoogle Scholar
  16. 16.
    Takala AK, Meurman O, Kleemola M, et al. Preceding respiratory infection predisposing for primary and secondary invasive Haemophilus influenzae type b disease. Pediatr Infect Dis J 1993;12(3):189–195.PubMedGoogle Scholar
  17. 17.
    Babiuk LA, Lawman MJ, Ohmann HB. Viral-bacterial synergistic interaction in respiratory disease. Adv Virus Res 1988;35:219–249.PubMedGoogle Scholar
  18. 18.
    Jakab GJ. Immune impairment of alveolar macrophage phagocytosis during influenza virus pneumonia. Am Rev Respir Dis 1982;126(5):778–782.PubMedGoogle Scholar
  19. 19.
    Jakab GJ. Mechanisms of bacterial superinfections in viral pneumonias. Schweiz Med Wochenschr 1985;115(3):75–86.PubMedGoogle Scholar
  20. 20.
    Glezen WP, Greenberg SB, Atmar RL, Piedra PA, Couch RB. Impact of respiratory virus infections on persons with chronic underlying conditions. JAMA 2000;283(4):499–505.PubMedGoogle Scholar
  21. 21.
    Ksiazek TG, Peters CJ, Rollin PE, et al. Identification of a new North American hantavirus that causes acute pulmonary insufficiency. Am J Trop Med Hyg 1995;52(2):117–123.PubMedGoogle Scholar
  22. 22.
    Chua KB, Bellini WJ, Rota PA, et al. Nipah virus: a recently emergent deadly paramyxovirus. Science 2000;288(5470):1432–1435.PubMedGoogle Scholar
  23. 23.
    Nichol ST, Spiropoulou CF, Morzunov S, et al. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 1993;262(5135):914–917.PubMedGoogle Scholar
  24. 24.
    McCoy L, Sorvillo F, Simon P. Varicella-related mortality in California, 1988–2000. Pediatr Infect Dis J 2004;23(6):498–503.PubMedGoogle Scholar
  25. 25.
    Nguyen HQ, Jumaan AO, Seward JF. Decline in mortality due to varicella after implementation of varicella vaccination in the United States. N Engl J Med 2005;352(5):450–458.PubMedGoogle Scholar
  26. 26.
    Taplitz RA, Jordan MC. Pneumonia caused by herpesviruses in recipients of hematopoietic cell transplants. Semin Respir Infect 2002;17(2):121–129.PubMedGoogle Scholar
  27. 27.
    Taubenberger JK, Reid AH, Krafft AE, Bijwaard KE, Fanning TG. Initial genetic characterization of the 1918 “Spanish” influenza virus. Science 1997;275(5307):1793–1796.PubMedGoogle Scholar
  28. 28.
    Tumpey TM, Basler CF, Aguilar PV, et al. Characterization of the reconstructed 1918 Spanish influenza pandemic virus. Science 2005;310(5745):77–80.PubMedGoogle Scholar
  29. 29.
    Fischer SA, Graham MB, Kuehnert MJ, et al. Transmission of lymphocytic choriomeningitis virus by organ transplantation. N Engl J Med 2006;354(21):2235–2249.PubMedGoogle Scholar
  30. 30.
    Murray K, Selleck P, Hooper P, et al. A morbillivirus that caused fatal disease in horses and humans. Science 1995;268(5207):94–97.PubMedGoogle Scholar
  31. 31.
    Cushing MM, Brat DJ, Mosunjac MI, et al. Fatal West Nile virus encephalitis in a renal transplant recipient. Am J Clin Pathol 2004;121(1):26–31.PubMedGoogle Scholar
  32. 32.
    Iwamoto M, Jernigan DB, Guasch A, et al. Transmission of West Nile virus from an organ donor to four transplant recipients. N Engl J Med 2003;348(22):2196–2203.PubMedGoogle Scholar
  33. 33.
    Srinivasan A, Burton EC, Kuehnert MJ, et al. Transmission of rabies virus from an organ donor to four transplant recipients. N Engl J Med 2005;352(11):1103–1111.PubMedGoogle Scholar
  34. 34.
    Rowe WP, Huebner RJ, Gilmore LK, Parrott RH, Ward TG. Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture. Proc Soc Exp Biol Med 1953;84(3):570–573.PubMedGoogle Scholar
  35. 35.
    Hilleman MR, Werner JH. Recovery of new agent from patients with acute respiratory illness. Proc Soc Exp Biol Med 1954;85(1):183–188.PubMedGoogle Scholar
  36. 36.
    Enders JF, Bell JA, Dingle JH, et al. Adenoviruses: group name proposed for new respiratory-tract viruses. Science 1956;124(3212):119–120.PubMedGoogle Scholar
  37. 37.
    Hierholzer JC. Adenoviruses in the immunocompromised host. Clin Microbiol Rev 1992;5(3):262–274.PubMedGoogle Scholar
  38. 38.
    Pham TT, Burchette JL Jr, Hale LP. Fatal disseminated adenovirus infections in immunocompromised patients. Am J Clin Pathol 2003;120(4):575–583.PubMedGoogle Scholar
  39. 39.
    Buescher EL. Respiratory disease and the adenoviruses. Med Clin North Am 1967;51(3):769–779.PubMedGoogle Scholar
  40. 40.
    De Jong JC, Wermenbol AG, Verweij-Uijterwaal MW, et al. Adenoviruses from human immunodeficiency virus-infected individuals, including two strains that represent new candidate serotypes Ad50 and Ad51 of species B1 and D, respectively. J Clin Microbiol 1999;37(12):3940–3945.PubMedGoogle Scholar
  41. 41.
    Brandt CD, Kim HW, Vargosko AJ, et al. Infections in 18,000 infants and children in a controlled study of respiratory tract disease. I. Adenovirus pathogenicity in relation to serologic type and illness syndrome. Am J Epidemiol 1969;90(6):484–500.PubMedGoogle Scholar
  42. 42.
    Ruuskanen O, Meurman O, Sarkkinen H. Adenoviral diseases in children: a study of 105 hospital cases. Pediatrics 1985;76(1):79–83.PubMedGoogle Scholar
  43. 43.
    Carballal G, Videla C, Misirlian A, Requeijo PV, Aguilar Mdel C. Adenovirus type 7 associated with severe and fatal acute lower respiratory infections in Argentine children. BMC Pediatr 2002;2:6.PubMedGoogle Scholar
  44. 44.
    Simila S, Ylikorkala O, Wasz-Hockert O. Type 7 adenovirus pneumonia. J Pediatr 1971;79(4):605–611.PubMedGoogle Scholar
  45. 45.
    Lang WR, Howden CW, Laws J, Burton JF. Bronchopneumonia with serious sequelae in children with evidence of adenovirus type 21 infection. Br Med J 1969;1(636):73–79.PubMedGoogle Scholar
  46. 46.
    Munoz FM, Piedra PA, Demmler GJ. Disseminated adenovirus disease in immunocompromised and immunocompetent children. Clin Infect Dis 1998;27(5):1194–1200.PubMedGoogle Scholar
  47. 47.
    Zahradnik JM. Adenovirus pneumonia. Semin Respir Infect 1987;2(2):104–111.PubMedGoogle Scholar
  48. 48.
    Dudding BA, Wagner SC, Zeller JA, Gmelich JT, French GR, Top FH Jr. Fatal pneumonia associated with adenovirus type 7 in three military trainees. N Engl J Med 1972;286(24):1289–1292.PubMedGoogle Scholar
  49. 49.
    Two fatal cases of adenovirus-related illness in previously healthy young adults-Illinois, 2000. MMWR Morb Mortal Wkly Rep 2001;50(26):553–555.Google Scholar
  50. 50.
    Becroft DM. Histopathology of fatal adenovirus infection of the respiratory tract in young children. J Clin Pathol 1967;20(4):561–569.PubMedGoogle Scholar
  51. 51.
    Ohori NP, Michaels MG, Jaffe R, Williams P, Yousem SA. Adenovirus pneumonia in lung transplant recipients. Hum Pathol 1995;26(10):1073–1079.PubMedGoogle Scholar
  52. 52.
    Bayon MN, Drut R. Cytologic diagnosis of adenovirus bronchopneumonia. Acta Cytol 1991;35(2):181–182.PubMedGoogle Scholar
  53. 53.
    Rocholl C, Gerber K, Daly J, Pavia AT, Byington CL. Adenoviral infections in children: the impact of rapid diagnosis. Pediatrics 2004;113(1 pt 1):e51–56.PubMedGoogle Scholar
  54. 54.
    Pinto A, Beck R, Jadavji T. Fatal neonatal pneumonia caused by adenovirus type 35. Report of one case and review of the literature. Arch Pathol Lab Med 1992;116(1):95–99.PubMedGoogle Scholar
  55. 55.
    Garcia AG, Fonseca ME, de Bonis M, Ramos HI, Ferro ZP, Nascimento JP. Morphological and virological studies in six autopsies of children with adenovirus pneumonia. Mem Inst Oswaldo Cruz 1993;88(1):141–147.PubMedGoogle Scholar
  56. 56.
    Hierholzer JC, Stone YO, Broderson JR. Antigenic relationships among the 47 human adenoviruses determined in reference horse antisera. Arch Virol 1991;121(1–4):179–197.PubMedGoogle Scholar
  57. 57.
    Turner PC, Bailey AS, Cooper RJ, Morris DJ. The polymerase chain reaction for detecting adenovirus DNA in formalin-fixed, paraffin-embedded tissue obtained post mortem. J Infect 1993;27(1):43–46.PubMedGoogle Scholar
  58. 58.
    Tran PL, Weinbach J, Opolon P, et al. Prevention of bleomycin-induced pulmonary fibrosis after adenovirus-mediated transfer of the bacterial bleomycin resistance gene. J Clin Invest 1997;99(4):608–617.PubMedGoogle Scholar
  59. 59.
    Demmler GJ. Adenoviruses. In: Balows A, ed. Manual of clinical microbiology. Washington, DC: American Society for Microbiology, 1994:947–955.Google Scholar
  60. 60.
    Schmaljohn CS. Nucleotide sequence of the L genome segment of Hantaan virus. Nucleic Acids Res 1990;18(22):6728.PubMedGoogle Scholar
  61. 61.
    Schmaljohn CS, Dalrymple JM. Analysis of Hantaan virus RNA: evidence for a new genus of bunyaviridae. Virology 1983;131(2):482–491.PubMedGoogle Scholar
  62. 62.
    Xiao SY, Leduc JW, Chu YK, Schmaljohn CS. Phylogenetic analyses of virus isolates in the genus Hantavirus, family Bunyaviridae. Virology 1994;198(1):205–217.PubMedGoogle Scholar
  63. 63.
    Hung T, Chou ZY, Zhao TX, Gan S, Yanagihara R. Morphology and morphogenesis of viruses of hemorrhagic fever with renal syndrome: inclusion bodies-ultrastructure marker of hantavirus-infected cells. Intervirology 1987;27:45–52.Google Scholar
  64. 64.
    Goldsmith CS, Elliott LH, Peters CJ, Zaki SR. Ultrastructural characteristics of Sin Nombre virus, causative agent of hantavirus pulmonary syndrome. Arch Virol 1995;140(12):2107–2122.PubMedGoogle Scholar
  65. 65.
    Martin ML, Lindsey-Regnery H, Sasso DR, McCormick JB, Palmer E. Distinction between Bunyaviridae genera by surface structure and comparison with Hantaan virus using negative stain electron microscopy. Arch Virol 1985;86(1–2):17–28.PubMedGoogle Scholar
  66. 66.
    Elliott LH, Ksiazek TG, Rollin PE, et al. Isolation of the causative agent of hantavirus pulmonary syndrome. Am J Trop Med Hyg 1994;51(1):102–108.PubMedGoogle Scholar
  67. 67.
    Update: hantavirus pulmonary syndrome-United States, 1993. Centers for Disease Control and Prevention, 1993.Google Scholar
  68. 68.
    Lee HW. World Health Organization (WHO) collaborating center for virus reference and research. In: Lee HW, Dalrymple JM, ed. Manual of hemorrhagic fever with renal syndrome. Seoul: Korea University, 1989:11–18.Google Scholar
  69. 69.
    Duchin JS, Koster FT, Peters CJ, et al. Hantavirus pulmonary syndrome: a clinical description of 17 patients with a newly recognized disease. The Hantavirus Study Group. N Engl J Med 1994;330(14):949–955.PubMedGoogle Scholar
  70. 70.
    Lee HW, Lee PW, Johnson KM. Isolation of the etiologic agent of Korean Hemorrhagic fever. J Infect Dis 1978;137(3):298–308.PubMedGoogle Scholar
  71. 71.
    Centers for Disease Control and Prevention. Outbreak of acute illness-southwestern United States, 1993. MMWR 1993;42:421–424.Google Scholar
  72. 71.
    Centers for Disease Control and Prevention. Outbreak of acute illness-southwestern United States, 1993. MMWR 1993;42:421–424.Google Scholar
  73. 72.
    Zaki SR, Greer PW, Coffield LM, et al. Hantavirus pulmonary syndrome. Pathogenesis of an emerging infectious disease. Am J Pathol 1995;146(3):552–579.PubMedGoogle Scholar
  74. 73.
    Zaki SR. Hantavirus-associated diseases. In: Connor DH, Chandler FW, Schwartz DA, Manz HJ, Lack EE, ed. Diagnostic pathology of infectious diseases. Stamford: Apple-ton and Lange, 1997:125–136.Google Scholar
  75. 74.
    Nolte KB, Feddersen RM, Foucar K, et al. Hantavirus pulmonary syndrome in the United States: a pathological description of a disease caused by a new agent. Hum Pathol 1995;26(1):110–120.PubMedGoogle Scholar
  76. 75.
    Lukes RJ. The pathology of thirty-nine fatal cases of epidemic hemorrhagic fever. Am J Med 1954;16(5):639–650.PubMedGoogle Scholar
  77. 76.
    Hullinghorst RL, Steer A. Pathology of epidemic hemorrhagic fever. Ann Intern Med 1953;38(1):77–101.PubMedGoogle Scholar
  78. 77.
    Kessler WH. Gross anatomic features found in 27 autopsies of epidemic hemorrhagic fever. Ann Intern Med 1953;38(1):73–76.PubMedGoogle Scholar
  79. 78.
    Steer A. Pathology of hemorrhagic fever: a comparison of the findings, 1951 and 1952. Am J Pathol 1955;31(2):201–221.PubMedGoogle Scholar
  80. 79.
    Hung T, Zhou JY, Tang YM, Zhao TX, Baek LJ, Lee HW. Identification of Hantaan virus-related structures in kidneys of cadavers with haemorrhagic fever with renal syndrome. Arch Virol 1992;122:187–199.PubMedGoogle Scholar
  81. 80.
    Kikuchi K, Imamura M, Ueno H, et al. An autopsy case of epidemic hemorrhagic fever (Korean hemorrhagic fever). Sapporo Medical Journal 1982;51:K17–K31.Google Scholar
  82. 81.
    Schmaljohn CS, Sugiyama K, Schmaljohn AL, Bishop DH. Baculovirus expression of the small genome segment of Hantaan virus and potential use of the expressed nucleocapsid protein as a diagnostic antigen. J Gen Virol 1988;69 (pt 4):777–786.PubMedGoogle Scholar
  83. 82.
    Feldmann H, Sanchez A, Morzunov S, et al. Utilization of autopsy RNA for the synthesis of the nucleocapsid antigen of a newly recognized virus associated with hantavirus pulmonary syndrome. Virus Res 1993;30(3):351–367.PubMedGoogle Scholar
  84. 83.
    Schwarz TF, Zaki SR, Morzunov S, Peters CJ, Nichol ST. Detection and sequence confirmation of Sin Nombre virus RNA in paraffin-embedded human tissues using one-step RT-PCR. J Virol Methods 1995;51(2–3):349–356.PubMedGoogle Scholar
  85. 84.
    Zaki SR, Khan AS, Goodman RA, et al. Retrospective diagnosis of hantavirus pulmonary syndrome, 1978–1993: implications for emerging infectious diseases. Arch Pathol Lab Med 1996;120(2):134–139.PubMedGoogle Scholar
  86. 85.
    Zaki SR, Albers RC, Greer PW, et al. Retrospective diagnosis of a 1983 case of fatal hantavirus pulmonary syndrome. Lancet 1994;343(8904):1037–1038.PubMedGoogle Scholar
  87. 86.
    Goldsmith CS, Tatti KM, Ksiazek TG, et al. Ultrastructural characterization of SARS coronavirus. Emerg Infect Dis 2004;10(2):320–326.PubMedGoogle Scholar
  88. 87.
    Ng ML, Tan SH, See EE, Ooi EE, Ling AE. Proliferative growth of SARS coronavirus in Vero E6 cells. J Gen Virol 2003;84 (pt 12):3291–3303.PubMedGoogle Scholar
  89. 88.
    Becker WB, Mcintosh K, Dees JH, Chanock RM. Morphogenesis of avian infectious bronchitis virus and a related human virus (strain 229E). J Virol 1967;1(5):1019–1027.PubMedGoogle Scholar
  90. 89.
    Dubois-Dalcq M, Holmes KV, Rentier B. Assembly of enveloped RNA viruses. New York: Springer-Verlag, 1984:100–119.Google Scholar
  91. 90.
    Oshiro LS, Schieble JH, Lennette EH. Electron microscopic studies of coronavirus. J Gen Virol 1971;12:161–168.PubMedGoogle Scholar
  92. 91.
    Peiris JS, Lai ST, Poon LL, et al. Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet 2003;361(9366):1319–1325.PubMedGoogle Scholar
  93. 92.
    Chong PY, Chui P, Ling AE, et al. Analysis of deaths during the severe acute respiratory syndrome (SARS) epidemic in Singapore: challenges in determining a SARS diagnosis. Arch Pathol Lab Med 2004;128(2):195–204.PubMedGoogle Scholar
  94. 93.
    Ding Y, Wang H, Shen H, et al. The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J Pathol 2003;200(3):282–289.PubMedGoogle Scholar
  95. 94.
    Franks TJ, Chong PY, Chui P, et al. Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore. Hum Pathol 2003;34(8):743–748.PubMedGoogle Scholar
  96. 95.
    Lang ZW, Zhang LJ, Zhang SJ, et al. A clinicopath-ological study on 3 cases of severe acute respiratory syndrome. Zhonghua Bing Li Xue Za Zhi 2003;32(3):201–204.PubMedGoogle Scholar
  97. 96.
    Leung WK, To KF, Chan PK, et al. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology 2003;125(4):1011–1017.PubMedGoogle Scholar
  98. 97.
    Nicholls JM, Poon LL, Lee KC, et al. Lung pathology of fatal severe acute respiratory syndrome. Lancet 2003;361(9371):1773–1778.PubMedGoogle Scholar
  99. 98.
    Hwang DM, Chamberlain DW, Poutanen SM, Low DE, Asa SL, Butany J. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol 2005;18(1):1–10.PubMedGoogle Scholar
  100. 99.
    Nakajima N, Asahi-Ozaki Y, Nagata N, et al. SARS coronavirus-infected cells in lung detected by new in situ hybridization technique. Jpn J Infect Dis 2003;56(3):139–141.PubMedGoogle Scholar
  101. 100.
    Shieh WJ, Hsiao CH, Paddock CD, et al. Immunohistochemical, in situ hybridization, and ultrastructural localization of SARS-associated coronavirus in lung of a fatal case of severe acute respiratory syndrome in Taiwan. Hum Pathol 2005;36(3):303–309.PubMedGoogle Scholar
  102. 101.
    To KF, Tong JH, Chan PK, et al. Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in-situ hybridization study of fatal cases. J Pathol 2004;202(2):157–163.PubMedGoogle Scholar
  103. 102.
    Katzenstein AL. Acute lung injury patterns: diffuse alveolar damage and bronchiolitis obliterans-organizing pneumonia. In: Katzenstein AL, ed. Katzenstein and Askin’s surgical pathology of non-neoplastic lung diseases. Philadelphia: Saunders, 1997:14–47.Google Scholar
  104. 103.
    Zaki SR. Measles. In: Connor DH, Chandler FW, Schwartz DA, Manz HJ, Lack EE, eds. Pathology of infectious diseases. Stamford, CT: Appleton and Lange, 1997:233–244.Google Scholar
  105. 104.
    Wong KT, Shieh WJ, Kumar S, et al. Nipah virus infection: pathology and pathogenesis of an emerging paramyxoviral zoonosis. Am J Pathol 2002;161(6):2153–2167.PubMedGoogle Scholar
  106. 105.
    Guarner J, Shieh WJ, Dawson J, et al. Immunohistochemical and in situ hybridization studies of influenza A virus infection in human lungs. Am J Clin Pathol 2000;114(2):227–233.PubMedGoogle Scholar
  107. 106.
    Kuiken T, Fouchier RA, Schutten M, et al. Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 2003;362(9380):263–270.PubMedGoogle Scholar
  108. 107.
    Haagmans BL, Kuiken T, Martina BE, et al. Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques. Nat Med 2004;10(3):290–293.PubMedGoogle Scholar
  109. 108.
    McAuliffe J, Vogel L, Roberts A, et al. Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys. Virology 2004;330(1):8–15.PubMedGoogle Scholar
  110. 109.
    Subbarao K, McAuliffe J, Vogel L, et al. Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice. J Virol 2004;78(7):3572–3577.PubMedGoogle Scholar
  111. 110.
    Roberts A, Vogel L, Guarner J, et al. Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters. J Virol 2005;79(1):503–511.PubMedGoogle Scholar
  112. 111.
    Ribbert D. Uber protozoenartige Zellen in der Niere eines syphilitischen Neugoborenen und in der Parotis von Kindern. Zentralbl Allg Pathol 1904;15:945–948.Google Scholar
  113. 112.
    Goodpasture EW, Talbot FB. Concerning the nature of “protozoan-like” cells in certain lesions of infancy. Am J Dis Child 1921;21:415–425.Google Scholar
  114. 113.
    Farber S, Wolback SB. Intranuclear and cytoplasmic inclusions (“protozoan-like bodies”) in the salivary glands and other organs of infants. Am J Pathol 1932;8:123–135.PubMedGoogle Scholar
  115. 114.
    Weller TH, Hanshaw JB, Scott DE. Serologic differentiation of viruses responsible for cytomegalic inclusion disease. Virology 1960;12:130–132.PubMedGoogle Scholar
  116. 115.
    Perot K, Walker CM, Spaete RR. Primary chimpanzee skin fibroblast cells are fully permissive for human cytomegalovirus replication. J Gen Virol 1992;73 (pt 12):3281–3284.PubMedGoogle Scholar
  117. 116.
    Riegler S, Hebart H, Einsele H, Brossart P, Jahn G, Sinzger C. Monocyte-derived dendritic cells are permissive to the complete replicative cycle of human cytomegalovirus. J Gen Virol 2000;81 (pt 2):393–399.PubMedGoogle Scholar
  118. 117.
    Mocarski ES. Cytomegaloviruses and their replication. In: Fields BN, Knipe DM, Howley PM, eds. Fields virology. 3rd ed. Philadelphia: Lippincott-Raven, 1996:2447–2492.Google Scholar
  119. 118.
    Wright HT Jr, Goodheart CR, Lielausis A. Human cytomegalovirus. Morphology by negative staining. Virology 1964;23:419–424.PubMedGoogle Scholar
  120. 119.
    Klemola E, Von Essen R, Henle G, Henle W. Infectious-mononucleosis-like disease with negative heterophil agglutination test. Clinical features in relation to Epstein-Barr virus and cytomegalovirus antibodies. J Infect Dis 1970;121(6):608–614.PubMedGoogle Scholar
  121. 120.
    Cohen JI, Corey GR. Cytomegalovirus infection in the normal host. Medicine (Baltimore) 1985;64(2):100–114.PubMedGoogle Scholar
  122. 121.
    Medearis DN Jr. Cytomegalic inclusion disease; an analysis of the clinical features based on the literature and six additional cases. Pediatrics 1957;19(3):467–480.PubMedGoogle Scholar
  123. 122.
    Ison MG, Fishman JA. Cytomegalovirus pneumonia in transplant recipients. Clin Chest Med 2005;26(4):691–705, viii.PubMedGoogle Scholar
  124. 123.
    Meyers JD, Flournoy N, Thomas ED. Nonbacterial pneumonia after allogeneic marrow transplantation: a review of ten years’ experience. Rev Infect Dis 1982;4(6):1119–1132.PubMedGoogle Scholar
  125. 124.
    Kotloff RM, Ahya VN, Crawford SW. Pulmonary complications of solid organ and hematopoietic stem cell transplantation. Am J Respir Crit Care Med 2004;170(1):22–48.PubMedGoogle Scholar
  126. 125.
    Balthesen M, Messerle M, Reddehase MJ. Lungs are a major organ site of cytomegalovirus latency and recurrence. J Virol 1993;67(9):5360–5366.PubMedGoogle Scholar
  127. 126.
    Stover DE, White DA, Romano PA, Gellene RA, Robeson WA. Spectrum of pulmonary diseases associated with the acquired immune deficiency syndrome. Am J Med 1985;78(3):429–437.PubMedGoogle Scholar
  128. 127.
    Herry I, Cadranel J, Antoine M, et al. Cytomegalo-virus-induced alveolar hemorrhage in patients with AIDS: a new clinical entity? Clin Infect Dis 1996;22(4):616–620.PubMedGoogle Scholar
  129. 128.
    Myerson D, Hackman RC, Nelson JA, Ward DC, McDougall JK. Widespread presence of histologically occult cytomegalovirus. Hum Pathol 1984;15(5):430–439.PubMedGoogle Scholar
  130. 129.
    Beschorner WE, Hutchins GM, Burns WH, Saral R, Tutschka PJ, Santos GW. Cytomegalovirus pneumonia in bone marrow transplant recipients: miliary and diffuse patterns. Am Rev Respir Dis 1980;122(1):107–114.PubMedGoogle Scholar
  131. 130.
    Wallace JM, Hannah J. Cytomegalovirus pneumonitis in patients with AIDS. Findings in an autopsy series. Chest 1987;92(2):198–203.PubMedGoogle Scholar
  132. 131.
    Strano AJ. Light microscopy of selected viral diseases (morphology of viral inclusion bodies). Pathol Annu 1976;11:53–75.PubMedGoogle Scholar
  133. 132.
    Kanich RE, Craighead JE. Human cytomegalovirus infection of cultured fibroblasts. II. Viral replicative sequence of a wild and an adapted strain. Lab Invest 1972;27(3):273–282.PubMedGoogle Scholar
  134. 133.
    Gorelkin L, Chandler FW, Ewing EP Jr. Staining qualities of cytomegalovirus inclusions in the lungs of patients with the acquired immunodeficiency syndrome: a potential source of diagnostic misinterpretation. Hum Pathol 1986;17(9):926–929.PubMedGoogle Scholar
  135. 134.
    Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis 2002;34(8):1094–1097.PubMedGoogle Scholar
  136. 135.
    Gleaves CA, Myerson D, Bowden RA, Hackman RC, Meyers JD. Direct detection of cytomegalovirus from bronchoalveolar lavage samples by using a rapid in situ DNA hybridization assay. J Clin Microbiol 1989;27(11):2429–2432.PubMedGoogle Scholar
  137. 136.
    Singer DB. Pathology of neonatal Herpes simplex virus infection. Perspect Pediatr Pathol 1981;6:243–278.PubMedGoogle Scholar
  138. 137.
    Feldman S, Stokes DC. Varicella zoster and herpes simplex virus pneumonias. Semin Respir Infect 1987;2(2):84–94.PubMedGoogle Scholar
  139. 138.
    Whitley RJ. Herpes simplex viruses. In: Fields BN, Knipe DM, Howley PM, eds. Fields virology. 3rd ed. Philadelphia: Lippincott-Raven, 1996:2297–2342.Google Scholar
  140. 139.
    Baringer JR. Recovery of herpes simplex virus from human sacral ganglions. N Engl J Med 1974;291(16):828–830.PubMedGoogle Scholar
  141. 140.
    Bastain FO, Rabson AS, Yee CL. Herpesvirus hominis: isolation from human trigeminal ganglion. Science 1972;178:306–307.Google Scholar
  142. 141.
    Corey L, Spear PG. Infections with herpes simplex viruses (1). N Engl J Med 1986;314(11):686–691.PubMedGoogle Scholar
  143. 142.
    Corey L, Spear PG. Infections with herpes simplex viruses (2). N Engl J Med 1986;314(12):749–757.PubMedGoogle Scholar
  144. 143.
    Nash G, Foley FD. Herpetic infection of the middle and lower respiratory tract. Am J Clin Pathol 1970;54(6):857–863.PubMedGoogle Scholar
  145. 144.
    Ramsey PG, Fife KH, Hackman RC, Meyers JD, Corey L. Herpes simplex virus pneumonia: clinical, virologic, and pathologic features in 20 patients. Ann Intern Med 1982;97(6):813–820.PubMedGoogle Scholar
  146. 145.
    Cherr GS, Meredith JW, Chang M. Herpes simplex virus pneumonia in trauma patients. J Trauma 2000;49(3):547–549.PubMedGoogle Scholar
  147. 146.
    Ferrari A, Luppi M, Potenza L, et al. Herpes simplex virus pneumonia during standard induction chemotherapy for acute leukemia: case report and review of literature. Leukemia 2005;19(11):2019–2021.PubMedGoogle Scholar
  148. 147.
    Hass GM. Hepato-adrenal necrosis with intranuclear inclusion bodies. Am J Pathol 1935;11:127–147.PubMedGoogle Scholar
  149. 148.
    Raga J, Chrystal V, Coovadia HM. Usefulness of clinical features and liver biopsy in diagnosis of disseminated herpes simplex infection. Arch Dis Child 1984;59(9):820–824.PubMedGoogle Scholar
  150. 149.
    Kimberlin DW. Neonatal herpes simplex infection. Clin Microbiol Rev 2004;17(1):1–13.PubMedGoogle Scholar
  151. 150.
    Lissauer TJ, Shaw PJ, Underhill G. Neonatal herpes simplex pneumonia. Arch Dis Child 1984;59(7):668–670.PubMedGoogle Scholar
  152. 151.
    Morrison SC, Comisky E, Fletcher BD. Calcification in the adrenal glands associated with disseminated herpes simplex infection. Pediatr Radiol 1988;18(3):240–241.PubMedGoogle Scholar
  153. 152.
    Nash G. Necrotizing tracheobronchitis and bronchopneumonia consistent with herpetic infection. Hum Pathol 1972;3(2):283–291.PubMedGoogle Scholar
  154. 153.
    Sherry MK, Klainer AS, Wolff M, Gerhard H. Herpetic tracheobronchitis. Ann Intern Med 1988;109(3):229–233.PubMedGoogle Scholar
  155. 154.
    Graham BS, Snell JD Jr. Herpes simplex virus infection of the adult lower respiratory tract. Medicine (Baltimore) 1983;62(6):384–393.PubMedGoogle Scholar
  156. 155.
    Morgan HR, Finland M. Isolation of herpes virus from a case of atypical pneumonia and erythema multiforme exu-dativum. Am J Med Sci 1949;217:92–95.PubMedGoogle Scholar
  157. 156.
    Prellner T, Flamholc L, Haidl S, Lindholm K, Widell A. Herpes simplex virus-the most frequently isolated pathogen in the lungs of patients with severe respiratory distress. Scand J Infect Dis 1992;24(3):283–292.PubMedGoogle Scholar
  158. 157.
    Tuxen DV, Cade JF, McDonald MI, Buchanan MR, Clark RJ, Pain MC. Herpes simplex virus from the lower respiratory tract in adult respiratory distress syndrome. Am Rev Respir Dis 1982;126(3):416–419.PubMedGoogle Scholar
  159. 158.
    Cowdry EV. The problem of intranuclear inclusions in virus diseases. Arch Pathol 1934;18:527–540.Google Scholar
  160. 159.
    Strickler JG, Manivel JC, Copenhaver CM, Kubic VL. Comparison of in situ hybridization and immunohistochemistry for detection of cytomegalovirus and herpes simplex virus. Hum Pathol 1990;21(4):443–448.PubMedGoogle Scholar
  161. 160.
    Arvin A. Varicella-zoster virus. In: Fields BN, Knipe DM, Howley PM, eds. Fields virology. 3rd ed. Philadelphia: Lippincott-Raven, 1996.Google Scholar
  162. 161.
    Silverstein S, Straus SE. Varicella-zoster virus: pathogenesis of latency and reactivation. In: Arvin AM, Gershon AA, eds. Varicella-zoster virus: virology and clinical practice. Cambridge, UK: Cambridge University Press, 2000:123–141.Google Scholar
  163. 162.
    Varicella-related deaths among adults-United States, 1997. MMWR Morb Mortal Wkly Rep 1997;46(19):409–412.Google Scholar
  164. 163.
    Kaneko T, Ishigatsubo Y. Varicella pneumonia in adults. Intern Med 2004;43(12):1105–1106.PubMedGoogle Scholar
  165. 164.
    Waring JJ, Neubuerger K, Geever EF. Severe forms of chickenpox in adults. Arch Intern Med 1942:384–408.Google Scholar
  166. 165.
    Choo PW, Donahue JG, Manson JE, Platt R. The epidemiology of varicella and its complications. J Infect Dis 1995;172(3):706–712.PubMedGoogle Scholar
  167. 166.
    Weber DM, Pellecchia JA. Varicella pneumonia: study of prevalence in adult men. JAMA 1965;192:572–573.PubMedGoogle Scholar
  168. 167.
    Triebwasser JH, Harris RE, Bryant RE, Rhoades ER. Varicella pneumonia in adults. Report of seven cases and a review of literature. Medicine (Baltimore) 1967;46(5):409–423.PubMedGoogle Scholar
  169. 168.
    Mermelstein RH, Freireich AW. Varicella pneumonia. Ann Intern Med 1961;55:456–463.PubMedGoogle Scholar
  170. 169.
    Feldman S. Varicella-zoster virus pneumonitis. Chest 1994;106(1 suppl):22S–27S.PubMedGoogle Scholar
  171. 170.
    Fehr T, Bossart W, Wahl C, Binswanger U. Disseminated varicella infection in adult renal allograft recipients: four cases and a review of the literature. Transplantation 2002;73(4):608–611.PubMedGoogle Scholar
  172. 171.
    Harger JH, Ernest JM, Thurnau GR, et al. Risk factors and outcome of varicella-zoster virus pneumonia in pregnant women. J Infect Dis 2002;185(4):422–427.PubMedGoogle Scholar
  173. 172.
    Miliauskas JR, Webber BL. Disseminated varicella at autopsy in children with cancer. Cancer 1984;53(7):1518–1525.PubMedGoogle Scholar
  174. 173.
    Sargent EN, Carson MJ, Reilly ED. Roentgenographic manifestations of varicella pneumonia with postmortem correlation. Am J Roentgenol Radium Ther Nucl Med 1966;98(2):305–317.PubMedGoogle Scholar
  175. 174.
    Johnson HN. Visceral lesions associated with varicella. Arch Pathol 1940:30:292–307.Google Scholar
  176. 175.
    Raider L. Calcification in chickenpox pneumonia. Chest 1971;60(5):504–507.PubMedGoogle Scholar
  177. 176.
    Brunton FJ, Moore ME. A survey of pulmonary calcification following adult chicken-pox. Br J Radiol 1969;42(496):256–259.PubMedGoogle Scholar
  178. 177.
    Grant RM, Weitzman SS, Sherman CG, Sirkin WL, Petric M, Tellier R. Fulminant disseminated varicella zoster virus infection without skin involvement. J Clin Virol 2002;24(1–2):7–12.PubMedGoogle Scholar
  179. 178.
    Grose C, Perrotta DM, Brunell PA, Smith GC. Cell-free varicella-zoster virus in cultured human melanoma cells. J Gen Virol 1979;43(1):15–27.PubMedGoogle Scholar
  180. 179.
    Wright PF, Webster RG. Orthomyxoviruses. In: Knipe DM, Howley PM, eds. Fields virology. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2001:1533–1579.Google Scholar
  181. 180.
    Cox NJ, Kawaoka, Y. Orthomyxoviruses: Influenza. In: Mahy BWJ, Collier L, eds. Topley and Wilson’s microbiology and microbial infections. London: Arnold, 1998:385–433.Google Scholar
  182. 181.
    Hers JFP. Changes in the respiratory mucosa resulting from infection with influenza virus. Br J Pathol Bacteriol 1957;73:565–568.Google Scholar
  183. 182.
    Hers JF, Masurel N, Mulder J. Bacteriology and histopa-thology of the respiratory tract and lungs in fatal Asian influenza. Lancet 1958;2(7057):1141–1143.PubMedGoogle Scholar
  184. 183.
    Martin CM, Kunin CM, Gottlieb LS, Barnes MW, Liu C, Finland M. Asian influenza A in Boston, 1957–1958. I. Observations in thirty-two influenza-associated fatal cases. AMA Arch Intern Med 1959;103(4):515–531.PubMedGoogle Scholar
  185. 184.
    Martin CM, Kunin CM, Gottlieb LS, Finland M. Asian influenza A in Boston, 1957–1958. II. Severe staphylococcal pneumonia complicating influenza. AMA Arch Intern Med 1959;103(4):532–542.PubMedGoogle Scholar
  186. 185.
    Noble RL, Lillington GA, Kempson RL. Fatal diffuse influenzal pneumonia: premortem diagnosis by lung biopsy. Chest 1973;63(4):644–646.PubMedGoogle Scholar
  187. 186.
    Oseasohn R, Adelson L, Kaji M. Clinicopathologic study of thirty-three fatal cases of Asian influenza. N Engl J Med 1959;260(11):509–518.PubMedGoogle Scholar
  188. 187.
    Yeldandi AV, Colby TV. Pathologic features of lung biopsy specimens from influenza pneumonia cases. Hum Pathol 1994;25(1):47–53.PubMedGoogle Scholar
  189. 188.
    Walsh JJ, Dietlein LF, Low FN, Burch GE, Mogabgab WJ. Bronchotracheal response in human influenza. Type A, Asian strain, as studied by light and electron microscopic examination of bronchoscopic biopsies. Arch Intern Med 1961;108:376–388.PubMedGoogle Scholar
  190. 189.
    Nolte KB, Alakija P, Oty G, et al. Influenza A virus infection complicated by fatal myocarditis. Am J Forensic Med Pathol 2000;21(4):375–379.PubMedGoogle Scholar
  191. 190.
    Guarner J, Paddock CD, Shieh WJ, et al. Histopathologic and immunohistochemical features of fatal influenza virus infections in children during the 2003–2004 season. Clin Infect Dis 2006;43:132–140.PubMedGoogle Scholar
  192. 191.
    Ungchusak K, Auewarakul P, Dowell SF, et al. Probable person-to-person transmission of avian influenza A (H5N1). N Engl J Med 2005;352(4):333–340.PubMedGoogle Scholar
  193. 192.
    Mulder J, Hers JFPh. Influenza. Groningen: Wolters-Noordhoff, 1972.Google Scholar
  194. 193.
    Bhat N, Wright JG, Broder KR, et al. Influenza-associated deaths among children in the United States, 2003–2004. N Engl J Med 2005;353(24):2559–2567.PubMedGoogle Scholar
  195. 194.
    van Riel D, Munster VJ, de Wit E, et al. H5N1 virus attachment to lower respiratory tract. Science 2006;312(5772):399.PubMedGoogle Scholar
  196. 195.
    Shinya K, Ebina M, Yamada S, Ono M, Kasai N, Kawaoka Y. Avian flu: influenza virus receptors in the human airway. Nature 2006;440(7083):435–436.PubMedGoogle Scholar
  197. 196.
    Uyeki TM. Influenza diagnosis and treatment in children: a review of studies on clinically useful tests and antiviral treatment for influenza. Pediatr Infect Dis J 2003;22(2):164–177.PubMedGoogle Scholar
  198. 197.
    Ruest A, Michaud S, Deslandes S, Frost EH. Comparison of the Directigen flu A+B test, the Quick Vue influenza test, and clinical case definition to viral culture and reverse transcription-PCR for rapid diagnosis of influenza virus infection. J Clin Microbiol 2003;41(8):3487–3493.PubMedGoogle Scholar
  199. 198.
    Kingsbury DW. Paromyxoviridae and their replication. In: Fields BN, Knipe DM, eds. Fields virology. 2nd ed. New York: Raven Press, 1990:945–962.Google Scholar
  200. 199.
    Kingsbury DW, Bratt MA, Choppin PW, et al,. Paramyxo-viridae. Intervirology 1978;10:137–152.Google Scholar
  201. 200.
    Palmer EL, Martin ML. Electron microscopy in viral diagnosis. Boca Raton, FL: CRC Press, 1988.Google Scholar
  202. 201.
    Centers for Disease Control and Prevention. Measles surveillance-United States. MMWR 1991;41(SS-6):1–7.Google Scholar
  203. 202.
    Babbott FL Jr, Gordon JE. Modern measles. Am J Med Sci 1954;228(3):334–361.PubMedGoogle Scholar
  204. 203.
    Goldberger J, Anderson JF. An experimental demonstration of the presence of the virus of measles in the mixed buccal and nasal secretions. JAMA 1911;57:476–478.Google Scholar
  205. 204.
    Norrby E, Oxman MN. Measles virus. In: Fields BN, Knipe DM, Chanock RM, Hirsch MS, Melnick JL, Monath TP, Roizman B, eds. Virology. 2nd ed. New York: Raven, 1990:1013–1044.Google Scholar
  206. 205.
    Centers for Disease Control and Prevention. Measles-Duval County, Florida, 1991–1992. MMWR 1993;42:81–83.Google Scholar
  207. 206.
    Gremillion DH, Crawford GE. Measles pneumonia in young adults. An analysis of 106 cases. Am J Med 1981;71(4):539–542.PubMedGoogle Scholar
  208. 207.
    Kipps A, Kaschula RO. Virus pneumonia following measles: a virological and histological study of autopsy material. S Afr Med J 1976;50(28):1083–1088.PubMedGoogle Scholar
  209. 208.
    Archibald RW, Weller RO, Meadow SR. Measles pneumonia and the nature of the inclusion-bearing giant cells: a light-and electron-microscope study. J Pathol 1971;103(1):27–34.PubMedGoogle Scholar
  210. 209.
    Breitfeld V, Hashida Y, Sherman FE, Odagiri K, Yunis EJ. Fatal measles infection in children with leukemia. Lab Invest 1973;28(3):279–291.PubMedGoogle Scholar
  211. 210.
    Monafo WJ, Haslam DB, Roberts RL, Zaki SR, Bellini WJ, Coffin CM. Disseminated measles infection after vaccination in a child with a congenital immunodeficiency. J Pediatr 1994;124(2):273–276.PubMedGoogle Scholar
  212. 211.
    Akhtar M, Young I. Measles giant cell pneumonia in an adult following long-term chemotherapy. Arch Pathol 1973;96(3):145–148.PubMedGoogle Scholar
  213. 212.
    Christensen PE, Schmidt H, Bang HO, Andersen V, Jordal B, Jensen O. An epidemic of measles in southern Greenland, 1951; measles in virgin soil. II. The epidemic proper. Acta Med Scand 1953;144(6):408–429.Google Scholar
  214. 213.
    Naniche D, Varior-Krishnan G, Cervoni F, et al. Human membrane cofactor protein (CD46) acts as a cellular receptor for measles virus. J Virol 1993;67(10):6025–6032.PubMedGoogle Scholar
  215. 214.
    Wild TF, Malvoisin E, Buckland R. Measles virus: both the haemagglutinin and fusion glycoproteins are required for fusion. J Gen Virol 1991;72 (pt 2):439–442.PubMedGoogle Scholar
  216. 215.
    Robbins FC. Measles: clinical features. Pathogenesis, pathology and complications. Am J Dis Child 1962;103:266–273.PubMedGoogle Scholar
  217. 216.
    Sherman FE, Ruckle G. In vivo and in vitro cellular changes specific for measles. AMA Arch Pathol 1958;65(6):587–599.PubMedGoogle Scholar
  218. 217.
    Lewis MJ, Cameron AH, Shah KJ, Purdham DR, Mann JR. Giant-cell pneumonia caused by measles and methotrexate in childhood leukaemia in remission. Br Med J 1978;1(6109):330–331.PubMedGoogle Scholar
  219. 218.
    Joliat G, Abetel G, Schindler AM, Kapanci Y. Measles giant cell pneumonia without rash in a case of lymphocytic lymphosarcoma. An electron microscopic study. Virchows Arch A Pathol Pathol Anat 1973;358(3):215–224.PubMedGoogle Scholar
  220. 219.
    Merz DC, Scheid A, Choppin PW. Importance of antibodies to the fusion glycoprotein of paramyxoviruses in the prevention of spread of infection. J Exp Med 1980;151(2):275–288.PubMedGoogle Scholar
  221. 220.
    Rauh LW, Schmidt R. Measles immunization with killed virus vaccine. Serum antibody titers and experience with exposure to measles epidemic. Am J Dis Child 1965;109:232–237.PubMedGoogle Scholar
  222. 221.
    Fulginiti VA, Eller JJ, Downie AW, Kempe CH. Altered reactivity to measles virus. Atypical measles in children previously immunized with inactivated measles virus vaccines. JAMA 1967;202(12):1075–1080.PubMedGoogle Scholar
  223. 222.
    Laptook A, Wind E, Nussbaum M, Shenker IR. Pulmonary lesions in atypical measles. Pediatrics 1978;62(1):42–46.PubMedGoogle Scholar
  224. 223.
    Norrby E, Enders-Ruckle G, ter Meulen V. Difference in the appearance of antibodies to structural components of measles virus after immunization with inactivated and live virus. J Infect Dis 1975;132:262–269.PubMedGoogle Scholar
  225. 224.
    Mallory FB, Medlar EM. The skin lesion in measles. J Med Res 1920;41:327–348.PubMedGoogle Scholar
  226. 225.
    Enders JF, McCarthy K, Mitus A, Cheatham WJ. Isolation of measles virus at autopsy in cases of giant-cell pneumonia without rash. N Engl J Med 1959;261:875–881.PubMedGoogle Scholar
  227. 226.
    Radoycich GE, Zuppan CW, Weeks DA, Krous HF, Langston C. Patterns of measles pneumonitis. Pediatr Pathol 1992;12(6):773–786.PubMedGoogle Scholar
  228. 227.
    Sobonya RE, Hiller FC, Pingleton W, Watanabe I. Fatal measles (rubeola) pneumonia in adults. Arch Pathol Lab Med 1978;102(7):366–371.PubMedGoogle Scholar
  229. 228.
    Suringa DW, Bank LJ, Ackerman AB. Role of measles virus in skin lesions and Koplik’s spots. N Engl J Med 1970;283(21):1139–1142.PubMedGoogle Scholar
  230. 229.
    Strano AJ. Viral pneumonias (viral interstitial pneumonitis). In: Binford DH, Connor DH, eds. Pathology of tropical and extraordinary diseases. Washington, DC: Armed Forces Institute of Pathology, 1976:57–64.Google Scholar
  231. 230.
    Becroft DM, Osborne DR. The lungs in fatal measles infection in childhood: pathological, radiological and immunological correlations. Histopathology 1980;4(4):401–412.PubMedGoogle Scholar
  232. 231.
    Kimura A, Tosaka K, Nakao T. Measles rash. Light and electron microscopic study of skin eruptions. Arch Virol 1975;47:295–307.PubMedGoogle Scholar
  233. 232.
    Allen MS, Talbot WH, McDonald RM. Atypical lymph-node hyperplasia after administration of attenuated, live measles vaccine. N Engl J Med 1966;274:667–678.Google Scholar
  234. 233.
    Dorfman RF, Warnke R. Lymphadenopathy simulating the malignant lymphomas. Hum Pathol 1974;5(5):519–550.PubMedGoogle Scholar
  235. 234.
    Stejskal J. Measles lymphadenopathy. Ultrastruct Pathol 1980;1(2):243–247.PubMedGoogle Scholar
  236. 235.
    Koffler D. Giant cell pneumonia; fluorescent antibody and histochemical studies on alveolar giant cells. Arch Pathol 1964;78:267–273.PubMedGoogle Scholar
  237. 236.
    McQuillin J, Bell TM, Gardner PS, Downham PS. Application of immunofluorescence to a study of measles. Arch Dis Child 1976;51(6):411–419.PubMedGoogle Scholar
  238. 237.
    Sata T, Kurata T, Aoyama Y, Sakaguchi M, Yamanouchi K, Takeda K. Analysis of viral antigens in giant cells of measles pneumonia by immunoperoxidase method. Virchows Arch A Pathol Anat Histopathol 1986;410(2):133–138.PubMedGoogle Scholar
  239. 238.
    Delage G, Brochu P, Robillard L, Jasmin G, Joncas JH, Lapointe N. Giant cell pneumonia due to respiratory syncytial virus. Occurrence in severe combined immunodeficiency syndrome. Arch Pathol Lab Med 1984;108(8):623–625.PubMedGoogle Scholar
  240. 239.
    Little BW, Tihen WS, Dickerman JD, Craighead JE. Giant cell pneumonia associated with parainfluenza virus type 3 infection. Hum Pathol 1981;12(5):478–481.PubMedGoogle Scholar
  241. 240.
    Weintrub PS, Sullender WM, Lombard C, Link MP, Arvin A. Giant cell pneumonia caused by parainfluenza type 3 in a patient with acute myelomonocytic leukemia. Arch Pathol Lab Med 1987;111(6):569–570.PubMedGoogle Scholar
  242. 241.
    Saito F, Yutani C, Imakita M, Ishibashi-Ueda H, Kanzaki T, Chiba Y. Giant cell pneumonia caused by varicella zoster virus in a neonate. Arch Pathol Lab Med 1989;113(2):201–203.PubMedGoogle Scholar
  243. 242.
    Murray K, Rogers R, Selvey L, et al. A novel morbillivirus pneumonia of horses and its transmission to humans. Emerg Infect Dis 1995;1(1):31–33.PubMedGoogle Scholar
  244. 243.
    McQuaid S, Isserte S, Allan GM, Taylor MJ, Allen IV, Cosby SL. Use of immunocytochemistry and biotiny-lated in situ hybridization for detecting measles virus in central nervous system tissue. J Clin Pathol 1990;43(4):329–333.PubMedGoogle Scholar
  245. 244.
    Kim TM, Brown HR, Lee SH, et al. Delayed acute measles inclusion body encephalitis in a 9-year-old girl: ultrastruc-tural, immunohistochemical, and in situ hybridization studies. Mod Pathol 1992;5(3):348–352.PubMedGoogle Scholar
  246. 245.
    Hummel KB, Erdman DD, Heath J, Bellini WJ. Baculovirus expression of the nucleoprotein gene of measles virus and utility of the recombinant protein in diagnostic enzyme immunoassays. J Clin Microbiol 1992;30(11):2874–2880.PubMedGoogle Scholar
  247. 246.
    Collins PL, Chanock RM, Mcintosh K. Parainfluenza viruses. In: Fields BN, Knipe DM, Howley PM, eds. Fields virology. 3rd ed. Philadelphia: Lippincott-Raven, 1996:1205–1241.Google Scholar
  248. 247.
    Glezen WP, Denny FW. Parainfluenza viruses. In: Evans A, Kaslow R, eds. Viral infections in humans: epidemiology and control. 4th ed. New York: Plenum, 1997:551–567.Google Scholar
  249. 248.
    Wendt CH, Weisdorf DJ, Jordan MC, Balfour HH Jr, Hertz MI. Parainfluenza virus respiratory infection after bone marrow transplantation. N Engl J Med 1992;326(14):921–926.PubMedGoogle Scholar
  250. 249.
    Lewis VA, Champlin R, Englund J, et al. Respiratory disease due to parainfluenza virus in adult bone marrow transplant recipients. Clin Infect Dis 1996;23(5):1033–1037.PubMedGoogle Scholar
  251. 250.
    Ljungman P. Respiratory virus infections in bone marrow transplant recipients: the European perspective. Am J Med 1997;102(3A):44–47.PubMedGoogle Scholar
  252. 251.
    Matar LD, McAdams HP, Palmer SM, et al. Respiratory viral infections in lung transplant recipients: radiologic findings with clinical correlation. Radiology 1999;213(3):735–742.PubMedGoogle Scholar
  253. 252.
    Cortez KJ, Erdman DD, Peret TC, et al. Outbreak of human parainfluenza virus 3 infections in a hematopoietic stem cell transplant population. J Infect Dis 2001;184(9):1093–1097.PubMedGoogle Scholar
  254. 253.
    Elizaga J, Olavarria E, Apperley J, Goldman J, Ward K. Parainfluenza virus 3 infection after stem cell transplant: relevance to outcome of rapid diagnosis and ribavirin treatment. Clin Infect Dis 2001;32(3):413–418.PubMedGoogle Scholar
  255. 254.
    Chakrabarti S, Collingham KE, Holder K, Fegan CD, Osman H, Milligan DW. Pre-emptive oral ribavirin therapy of paramyxovirus infections after haematopoietic stem cell transplantation: a pilot study. Bone Marrow Transplant 2001;28(8):759–763.PubMedGoogle Scholar
  256. 255.
    Akizuki S, Nasu N, Setoguchi M, Yoshida S, Higuchi Y, Yamamoto S. Parainfluenza virus pneumonitis in an adult. Arch Pathol Lab Med 1991;115(8):824–826.PubMedGoogle Scholar
  257. 256.
    Apalsch AM, Green M, Ledesma-Medina J, Nour B, Wald ER. Parainfluenza and influenza virus infections in pediatric organ transplant recipients. Clin Infect Dis 1995;20(2):394–399.PubMedGoogle Scholar
  258. 257.
    Butnor KJ, Sporn TA. Human parainfluenza virus giant cell pneumonia following cord blood transplant associated with pulmonary alveolar proteinosis. Arch Pathol Lab Med 2003;127(2):235–238.PubMedGoogle Scholar
  259. 258.
    Madden JF, Burchette JL Jr, Hale LP. Pathology of parainfluenza virus infection in patients with congenital immunodeficiency syndromes. Hum Pathol 2004;35(5):594–603.PubMedGoogle Scholar
  260. 259.
    Jarvis WR, Middleton PJ, Gelfand EW. Parainfluenza pneumonia in severe combined immunodeficiency disease. J Pediatr 1979;94(3):423–425.PubMedGoogle Scholar
  261. 260.
    Frank JA Jr, Warren RW, Tucker JA, Zeller J, Wilfert CM. Disseminated parainfluenza infection in a child with severe combined immunodeficiency. Am J Dis Child 1983;137(12):1172–1174.PubMedGoogle Scholar
  262. 261.
    Gardner PS, McQuillin J, McGuckin R, Ditchburn RK. Observations on clinical and immunofluorescent diagnosis of parainfluenza virus infections. Br Med J 1971;2(752):7–12.PubMedGoogle Scholar
  263. 262.
    Welliver RC, Wong DT, Sun M, McCarthy N. Parainfluenza virus bronchiolitis. Epidemiology and pathogenesis. Am J Dis Child 1986;140(1):34–40.PubMedGoogle Scholar
  264. 263.
    Waner JL, Whitehurst NJ, Downs T, Graves DG. Production of monoclonal antibodies against parainfluenza 3 virus and their use in diagnosis by immunofluorescence. J Clin Microbiol 1985;22(4):535–538.PubMedGoogle Scholar
  265. 264.
    Minnich L, Ray CG. Comparison of direct immunofluorescent staining of clinical specimens for respiratory virus antigens with conventional isolation techniques. J Clin Microbiol 1980;12(3):391–394.PubMedGoogle Scholar
  266. 265.
    Collins PL, Mcintosh K, Chanock RM. Respiratory syncytial virus. In: Fields BN, Knipe DM, Howley PM, eds. Fields virology. 3rd ed. Philadelphia: Lippincott-Raven, 1996:1313–1351.Google Scholar
  267. 266.
    Mcintosh K. Respiratory syncytial virus. In: Evans A, Kaslow R, eds. Viral infections in humans: epidemiology and control. 4th ed. New York: Plenum, 1997:691–705.Google Scholar
  268. 267.
    Adams JM. Primary virus infection with cytoplasmic inclusion bodies. Study of an epidemic involving thirty-two infants with nine deaths. JAMA 1947;116:1037–1039.Google Scholar
  269. 268.
    Aherne W, Bird T, Court SD, Gardner PS, McQuillin J. Pathological changes in virus infections of the lower respiratory tract in children. J Clin Pathol 1970;23(1):7–18.PubMedGoogle Scholar
  270. 269.
    Englund JA, Sullivan CJ, Jordan MC, Dehner LP, Vercellotti GM, Balfour HH Jr. Respiratory syncytial virus infection in immunocompromised adults. Ann Intern Med 1988;109(3):203–208.PubMedGoogle Scholar
  271. 270.
    Hall CB, Kopelman AE, Douglas RG Jr, Geiman JM, Meagher MP. Neonatal respiratory syncytial virus infection. N Engl J Med 1979;300(8):393–396.PubMedGoogle Scholar
  272. 271.
    Kurlandsky LE, French G, Webb PM, Porter DD. Fatal respiratory syncytial virus pneumonitis in a previously healthy child. Am Rev Respir Dis 1988;138(2):468–472.PubMedGoogle Scholar
  273. 272.
    Levenson RM, Kantor OS. Fatal pneumonia in an adult due to respiratory syncytial virus. Arch Intern Med 1987;147(4):791–792.PubMedGoogle Scholar
  274. 273.
    Neilson KA, Yunis EJ. Demonstration of respiratory syncytial virus in an autopsy series. Pediatr Pathol 1990;10(4):491–502.PubMedGoogle Scholar
  275. 274.
    Zaki SR, Bellini WJ. Measles. In: Connor DH, Chandler FW, Schwartz DA, Manz HJ, Lack EE, eds. Pathology of infectious diseases. Stamford, CT: Appleton and Lange, 1997:233–244.Google Scholar
  276. 275.
    Ahluwalia GS, Hammond GW. Comparison of cell culture and three enzyme-linked immunosorbent assays for the rapid diagnosis of respiratory syncytial virus from nasopharyngeal aspirate and tracheal secretion specimens. Diagn Microbiol Infect Dis 1988;9(3):187–192.PubMedGoogle Scholar
  277. 276.
    Bustamante-Calvillo ME, Velazquez FR, Cabrera-Munoz L, et al. Molecular detection of respiratory syncytial virus in postmortem lung tissue samples from Mexican children deceased with pneumonia. Pediatr Infect Dis J 2001;20(5):495–501.PubMedGoogle Scholar
  278. 277.
    Hall CB, Douglas RG Jr. Clinically useful method for the isolation of respiratory syncytial virus. J Infect Dis 1975;131(1):1–5.PubMedGoogle Scholar
  279. 278.
    Hall CB, Douglas RG Jr, Geiman JM. Respiratory syncytial virus infections in infants: quantitation and duration of shedding. J Pediatr 1976;89(1):11–15.PubMedGoogle Scholar
  280. 279.
    Kao CL, Mcintosh K, Fernie B, Talis A, Pierik L, Anderson L. Monoclonal antibodies for the rapid diagnosis of respiratory syncytial virus infection by immunofluorescence. Diagn Microbiol Infect Dis 1984;2(3):199–206.PubMedGoogle Scholar
  281. 280.
    Kim HW, Wyatt RG, Fernie BF, et al. Respiratory syncytial virus detection by immunofluorescence in nasal secretions with monoclonal antibodies against selected surface and internal proteins. J Clin Microbiol 1983;18(6):1399–1404.PubMedGoogle Scholar
  282. 281.
    King JC Jr, Burke AR, Clemens JD, et al. Respiratory syncytial virus illnesses in human immunodeficiency virus-and noninfected children. Pediatr Infect Dis J 1993;12(9):733–739.PubMedGoogle Scholar
  283. 282.
    van den Hoogen BG, de Jong JC, Groen J, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 2001;7(6):719–724.PubMedGoogle Scholar
  284. 283.
    van den Hoogen BG, van Doornum GJ, Fockens JC, et al. Prevalence and clinical symptoms of human metapneumo-virus infection in hospitalized patients. J Infect Dis 2003;188(10):1571–1577.PubMedGoogle Scholar
  285. 284.
    Boivin G, Abed Y, Pelletier G, et al. Virological features and clinical manifestations associated with human meta-pneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis 2002;186(9):1330–1334.PubMedGoogle Scholar
  286. 285.
    Esper F, Boucher D, Weibel C, Martinello RA, Kahn JS. Human metapneumovirus infection in the United States: clinical manifestations associated with a newly emerging respiratory infection in children. Pediatrics 2003;111(6 pt 1):1407–1410.PubMedGoogle Scholar
  287. 286.
    Peiris JS, Tang WH, Chan KH, et al. Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis 2003;9(6):628–633.PubMedGoogle Scholar
  288. 287.
    Williams JV, Harris PA, Tollefson SJ, et al. Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 2004;350(5):443–450.PubMedGoogle Scholar
  289. 288.
    Williams JV, Martino R, Rabella N, et al. A prospective study comparing human metapneumovirus with other respiratory viruses in adults with hematologic malignancies and respiratory tract infections. J Infect Dis 2005;192(6):1061–1065.PubMedGoogle Scholar
  290. 289.
    Cane PA, van den Hoogen BG, Chakrabarti S, Fegan CD, Osterhaus AD. Human metapneumovirus in a haematopoietic stem cell transplant recipient with fatal lower respiratory tract disease. Bone Marrow Transplant 2003;31(4):309–310.PubMedGoogle Scholar
  291. 290.
    Pelletier G, Dery P, Abed Y, Boivin G. Respiratory tract reinfections by the new human Metapneumovirus in an immunocompromised child. Emerg Infect Dis 2002;8(9):976–978.PubMedGoogle Scholar
  292. 291.
    Kuiken T, van den Hoogen BG, van Riel DA, et al. Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract. Am J Pathol 2004;164(6):1893–1900.PubMedGoogle Scholar
  293. 292.
    Sumino KC, Agapov E, Pierce RA, et al. Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. J Infect Dis 2005;192(6):1052–1060.PubMedGoogle Scholar
  294. 293.
    Vargas SO, Kozakewich HP, Perez-Atayde AR, McAdam AJ. Pathology of human metapneumovirus infection: insights into the pathogenesis of a newly identified respiratory virus. Pediatr Dev Pathol 2004;7(5):478–486; discussion 421.PubMedGoogle Scholar
  295. 294.
    Chan PK, To KF, Wu A, et al. Human metapneumovirus-associated atypical pneumonia and SARS. Emerg Infect Dis 2004;10(3):497–500.PubMedGoogle Scholar
  296. 295.
    From the Centers for Disease Control and Prevention. Outbreak of Hendra-like virus—Malaysia and Singapore, 1998–1999. JAMA 1999;281(19):1787–1788.Google Scholar
  297. 296.
    Chua KB, Goh KJ, Wong KT, et al. Fatal encephalitis due to Nipah virus among pig-farmers in Malaysia. Lancet 1999;354(9186):1257–1259.PubMedGoogle Scholar
  298. 297.
    Paton NI, Leo YS, Zaki SR, et al. Outbreak of Nipah-virus infection among abattoir workers in Singapore. Lancet 1999;354(9186):1253–1256.PubMedGoogle Scholar
  299. 298.
    Tambyah PA, Tan JH, Ong BK, Ho KH, Chan KP. First case of Nipah virus encephalitis in Singapore. Intern Med J 2001;31(2):132–133.PubMedGoogle Scholar
  300. 299.
    Parashar UD, Sunn LM, Ong F, et al. Case-control study of risk factors for human infection with a new zoonotic paramyxovirus, Nipah virus, during a 1998–1999 outbreak of severe encephalitis in Malaysia. J Infect Dis 2000;181(5):1755–1759.PubMedGoogle Scholar
  301. 300.
    Goh KJ, Tan CT, Chew NK, et al. Clinical features of Nipah virus encephalitis among pig farmers in Malaysia. N Engl J Med 2000;342(17):1229–1235.PubMedGoogle Scholar
  302. 301.
    Lee KE, Umapathi T, Tan CB, et al. The neurological manifestations of Nipah virus encephalitis, a novel paramyxovirus. Ann Neurol 1999;46(3):428–432.PubMedGoogle Scholar
  303. 302.
    Harcourt BH, Tamin A, Ksiazek TG, et al. Molecular characterization of Nipah virus, a newly emergent paramyxovirus. Virology 2000;271(2):334–349.PubMedGoogle Scholar
  304. 303.
    Hsu VP, Hossain MJ, Parashar UD, et al. Nipah virus encephalitis reemergence, Bangladesh. Emerg Infect Dis 2004;10(12):2082–2087.PubMedGoogle Scholar
  305. 304.
    Chadha MS, Comer JA, Lowe L, et al. Nipah virus-associated encephalitis outbreak, Siliguri, India. Emerg Infect Dis 2006;12(2):235–240.PubMedGoogle Scholar
  306. 305.
    Yob JM, Field H, Rashdi AM, et al. Nipah virus infection in bats (order Chiroptera) in peninsular Malaysia. Emerg Infect Dis 2001;7(3):439–441.PubMedGoogle Scholar
  307. 306.
    Halpin K, Young PL, Field HE, Mackenzie JS. Isolation of Hendra virus from pteropid bats: a natural reservoir of Hendra virus. J Gen Virol 2000;81(pt 8):1927–1932.PubMedGoogle Scholar
  308. 307.
    Olson JG, Rupprecht C, Rollin PE, et al. Antibodies to Nipah-like virus in bats (Pteropus lylei), Cambodia. Emerg Infect Dis 2002;8(9):987–988.PubMedGoogle Scholar
  309. 308.
    Reynes JM, Counor D, Ong S, et al. Nipah virus in Lyle’s flying foxes, Cambodia. Emerg Infect Dis 2005;11(7):1042–1047.PubMedGoogle Scholar
  310. 309.
    Field H, Young P, Yob JM, Mills J, Hall L, Mackenzie J. The natural history of Hendra and Nipah viruses. Microbes Infect 2001;3(4):307–314.PubMedGoogle Scholar
  311. 310.
    Lamb RA, Kolakofsky D. Paramyxoviridae. In: Knipe DM, Howley PM, eds. Fields virology. 4th ed. Philadelphia: Lippincott Williams & Wilkins, 2001:1305–1340.Google Scholar
  312. 311.
    Goldsmith CS, Whistler T, Rollin PE, et al. Elucidation of Nipah virus morphogenesis and replication using ultra-structural and molecular approaches. Virus Res 2003;92(1):89–98.PubMedGoogle Scholar
  313. 312.
    Hyatt AD, Zaki SR, Goldsmith CS, Wise TG, Hengstberger SG. Ultrastructure of Hendra virus and Nipah virus within cultured cells and host animals. Microbes Infect 2001;3(4):297–306.PubMedGoogle Scholar
  314. 313.
    Selvey LA, Wells RM, McCormack JG, et al. Infection of humans and horses by a newly described morbillivirus. Med J Aust 1995;162(12):642–645.PubMedGoogle Scholar
  315. 314.
    O’Sullivan JD, Allworth AM, Paterson DL, et al. Fatal encephalitis due to novel paramyxovirus transmitted from horses. Lancet 1997;349(9045):93–95.PubMedGoogle Scholar
  316. 315.
    Hooper P, Zaki S, Daniels P, Middleton D. Comparative pathology of the diseases caused by Hendra and Nipah viruses. Microbes Infect 2001;3(4):315–322.PubMedGoogle Scholar
  317. 316.
    Tanimura N, Imada T, Kashiwazaki Y, et al. Reactivity of anti-Nipah virus monoclonal antibodies to formalin-fixed, paraffin-embedded lung tissues from experimental Nipah and Hendra virus infections. J Vet Med Sci 2004;66(10):1263–1266.PubMedGoogle Scholar
  318. 317.
    Harcourt BH, Lowe L, Tamin A, et al. Genetic characterization of Nipah virus, Bangladesh, 2004. Emerg Infect Dis 2005;11(10):1594–1597.PubMedGoogle Scholar
  319. 318.
    Smith IL, Halpin K, Warrilow D, Smith GA. Development of a fluorogenic RT-PCR assay (TaqMan) for the detection of Hendra virus. J Virol Methods 2001;98(1):33–40.PubMedGoogle Scholar
  320. 319.
    Guillaume V, Lefeuvre A, Faure C, et al. Specific detection of Nipah virus using real-time RT-PCR (TaqMan). J Virol Methods 2004;120(2):229–237.PubMedGoogle Scholar
  321. 320.
    Allander T, Tammi MT, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B. Cloning of a human parvovirus by molecular screening of respiratory tract samples. Proc Natl Acad Sci USA 2005;102(36):12891–12896.PubMedGoogle Scholar
  322. 321.
    Heegaard ED, Brown KE. Human parvovirus B19. Clin Microbiol Rev 2002;15(3):485–505.PubMedGoogle Scholar
  323. 322.
    Anderson L, Zaki SR, Török TJ. Parvovirus infections (Erythema infectiosum). In: Wilfert CM, ed. Pediatric Infectious Diseases. Philadelphia: Current Medicine, 1999: 3.1–3.20.Google Scholar
  324. 323.
    Schwarz TF, Nerlich A, Hottentrager B, et al. Parvovirus B19 infection of the fetus. Histology and in situ hybridization. Am J Clin Pathol 1991;96(1):121–126.PubMedGoogle Scholar
  325. 324.
    Anand A, Gray ES, Brown T, Clewley JP, Cohen BJ. Human parvovirus infection in pregnancy and hydrops fetalis. N Engl J Med 1987;316(4):183–186.PubMedGoogle Scholar
  326. 325.
    Caul EO, Usher MJ, Burton PA. Intrauterine infection with human parvovirus B19: a light and electron microscopy study. J Med Virol 1988;24(1):55–66.PubMedGoogle Scholar
  327. 326.
    Krause JR, Penchansky L, Knisely AS. Morphological diagnosis of parvovirus B19 infection. A cytopathic effect easily recognized in air-dried, formalin-fixed bone marrow smears stained with hematoxylin-eosin or Wright-Giemsa. Arch Pathol Lab Med 1992;116(2):178–180.PubMedGoogle Scholar
  328. 327.
    Morey AL, Keeling JW, Porter HJ, Fleming KA. Clinical and histopathological features of parvovirus B19 infection in the human fetus. Br J Obstet Gynaecol 1992;99(7):566–574.PubMedGoogle Scholar
  329. 328.
    Salimans MM, van de Rijke FM, Raap AK, van Elsacker-Niele AM. Detection of parvovirus B19 DNA in fetal tissues by in situ hybridisation and polymerase chain reaction. J Clin Pathol 1989;42(5):525–530.PubMedGoogle Scholar
  330. 329.
    Morey AL, O’Neill HJ, Coyle PV, Fleming KA. Immuno-histological detection of human parvovirus B19 in formalin-fixed, paraffin-embedded tissues. J Pathol 1992;166(2):105–108.PubMedGoogle Scholar
  331. 330.
    Morey AL, Ferguson DJ, Fleming KA. Combined immu-nocytochemistry and non-isotopic in situ hybridization for the ultrastructural investigation of human parvovirus B19 infection. Histochem J 1995;27(1):46–53.PubMedGoogle Scholar
  332. 331.
    Morey AL, Ferguson DJ, Leslie KO, Taatjes DJ, Fleming KA. Intracellular localization of parvovirus B19 nucleic acid at the ultrastructural level by in situ hybridization with digoxigenin-labelled probes. Histochem J 1993;25(6):421–429.PubMedGoogle Scholar
  333. 332.
    Musiani M, Roda A, Zerbini M, et al. Detection of parvovirus B19 DNA in bone marrow cells by chemilumines-cence in situ hybridization. J Clin Microbiol 1996;34(5):1313–1316.PubMedGoogle Scholar
  334. 333.
    Zaki SR, Peters CJ. Viral hemorrhagic fevers. In: Connor DH, Chandler FW, Schwartz DA, Manz HJ, Lack EE, eds. Pathology of infectious diseases. Stamford, CT: Appleton and Lange, 1997:347–364.Google Scholar
  335. 334.
    Edington GM, White HA. The pathology of Lassa fever. Trans R Soc Trop Med Hyg 1972;66(3):381–389.PubMedGoogle Scholar
  336. 335.
    McCormick JB, Walker DH, King IJ, et al. Lassa virus hepatitis: a study of fatal Lassa fever in humans. Am J Trop Med Hyg 1986;35(2):401–407.PubMedGoogle Scholar
  337. 336.
    Walker DH, McCormick JB, Johnson KM, et al. Pathologic and virologic study of fatal Lassa fever in man. Am J Pathol 1982;107(3):349–356.PubMedGoogle Scholar
  338. 337.
    Eisner B, Schwarz E, Mando OG, Maiztegui J, Vilches A. Pathology of 12 fatal cases of Argentine hemorrhagic fever. Am J Trop Med Hyg 1973;22(2):229–236.Google Scholar
  339. 338.
    Child PL, MacKenzie RB, Valverde LR, Johnson KM. Bolivian hemorrhagic fever. A pathologic description. Arch Pathol 1967;83(5):434–445.PubMedGoogle Scholar
  340. 339.
    Baskerville A, Satti A, Murphy FA, Simpson DI. Congo-Crimean haemorrhagic fever in Dubai: histopathological studies. J Clin Pathol 1981;34(8):871–874.PubMedGoogle Scholar
  341. 340.
    Joubert JR, King JB, Rossouw DJ, Cooper R. A nosocomial outbreak of Crimean-Congo haemorrhagic fever at Tygerberg Hospital. Part III. Clinical pathology and pathogenesis. S Afr Med J 1985;68(10):722–728.PubMedGoogle Scholar
  342. 341.
    Abdel-Wahab KS, El Baz LM, El-Tayeb EM, Omar H, Ossman MA, Yasin W. Rift Valley Fever virus infections in Egypt: pathological and virological findings in man. Trans R Soc Trop Med Hyg 1978;72(4):392–396.PubMedGoogle Scholar
  343. 342.
    Burt FJ, Swanepoel R, Shieh WJ, et al. Immunohistochemi-cal and in situ localization of Crimean-Congo hemorrhagic fever (CCHF) virus in human tissues and implications for CCHF pathogenesis. Arch Pathol Lab Med 1997;121(8):839–846.PubMedGoogle Scholar
  344. 343.
    Strano AJ. Yellow fever. In: Binford CH, Connor DH, eds. Pathology of tropical and extraordinary diseases. Washington, DC: Armed Forces Institute of Pathology, 1976:1–4.Google Scholar
  345. 344.
    Burke T. Dengue haemorrhagic fever: a pathological study. Trans R Soc Trop Med Hyg 1968;62(5):682–692.PubMedGoogle Scholar
  346. 345.
    Maiztegui JI, Laguens RP, Cossio PM, et al. Ultrastru-ctural and immunohistochemical studies in five cases of Argentine hemorrhagic fever. J Infect Dis 1975;132(1):35–53.PubMedGoogle Scholar
  347. 346.
    Salas R, de Manzione N, Tesh RB, et al. Venezuelan haemorrhagic fever. Lancet 1991;338(8774):1033–1036.PubMedGoogle Scholar
  348. 347.
    van Velden DJ, Meyer JD, Olivier J, Gear JH, Mcintosh B. Rift Valley fever affecting humans in South Africa: a clini-copathological study. S Afr Med J 1977;51(24):867–871.PubMedGoogle Scholar
  349. 348.
    Bhamarapravati N, Tuchinda P, Boonyapaknavik V. Pathology of Thailand haemorrhagic fever: a study of 100 autopsy cases. Ann Trop Med Parasitol 1967;61(4):500–510.PubMedGoogle Scholar
  350. 349.
    Gubler DJ, Zaki SR. Dengue and other viral hemorrhagic fevers. In: Horsburgh CR, Nelson AM, eds. Pathology of emerging infections. Washington, DC: American Society for Microbiology, 1998:43–72.Google Scholar
  351. 350.
    Paddock CD, Nicholson WL, Bhatnagar J, et al. Fatal hemorrhagic fever caused by West Nile virus in the United States. Clin Infect Dis 2006;42(11):1527–1535.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Sherif R. Zaki
    • 1
  • Christopher D. Paddock
    • 2
  1. 1.Infectious Disease Pathology Activity, Department of Infectious Disease Pathology ActivityCenters for Disease Control and PreventionAtlantaUSA
  2. 2.Department of Infectious Disease Pathology ActivityCenters for Disease Control and PreventionAtlantaUSA

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