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Cell Regeneration in Lung Injury

  • Z. Bromberg
  • C. S. Deutschman
  • Y. G. Weiss
Conference paper
  • 691 Downloads

Abstract

The acute respiratory distress syndrome (ARDS) is a lethal inflammatory disorder of the lung. Its incidence is estimated at 75 cases per 100,000 population and appears to be increasing [1]. Even with optimal treatment, mortality is about 30% [1, 2, 3]. As such, ARDS represents a major public health problem. The effects of two recent crises created by unusual viral infections of the respiratory tract — the severe acute respiratory syndrome (SARS) epidemic caused by the novel SARS coronavirus [4, 5] and the bird flu [6] highlight the importance of research into ARDS. Both viruses cause an ARDS-like picture. Because lung repair and regeneration contribute substantially to the pathophysiology of ARDS, understanding these processes is essential [7]. This chapter focuses on specific cell populations and markers involved in cell division and regeneration. In addition, a brief review of two pathways intimately associated with cell division is provided because of their potential for pharmacologic manipulation.

Keywords

Lung Injury Hepatocyte Growth Factor Acute Lung Injury Idiopathic Pulmonary Fibrosis Acute Respiratory Distress Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science + Business Media Inc. 2007

Authors and Affiliations

  • Z. Bromberg
    • 1
  • C. S. Deutschman
    • 2
  • Y. G. Weiss
    • 1
  1. 1.Department of Anesthesiology and Critical Care MedicineHadassah Medical OrganizationJerusalemIsrael
  2. 2.Department of Anesthesiology and Critical CareUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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