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CD8+ T-Cell Priming During a Central Nervous System Infection with Mouse Hepatitis Virus

  • Katherine C. MacNamara
  • Susan R. Weiss
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 581)

Keywords

Enhance Green Fluorescent Protein Mouse Hepatitis Virus Early Transfer Spike Glycoprotein Post Transfer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Ontiveros, E., Kim, T. S., et al., 2003, Enhanced virulence mediated by the murine coronavirus, mouse hepatitis virus strain JHM, is associated with a glycine at residue 310 of the spike glycoprotein. J. Virol. 77:10260-10269.CrossRefPubMedGoogle Scholar
  2. 2.
    MacNamara, K. C., Chua, M. M., et al., 2005, Increased epitope-specific CD8+ T cells prevent murine coronavirus spread to the spinal cord and subsequent demyelination, J. Virol. 79:3370-3381.CrossRefPubMedGoogle Scholar
  3. 3.
    Brandle, D., Burki, K., et al., 1991, Involvement of both T cell receptor V alpha and V beta variable region domains and alpha chain junctional region in viral antigen recognition, Eur. J. Immunol. 21: 2195-2202.CrossRefPubMedGoogle Scholar
  4. 4.
    DasSarma, J., Scheen, E., et al., 2002, Enhanced green fluorescent protein expression may be used to  monitor murine coronavirus spread in vitro and in the mouse central nervous system, J. Neurovirol. 8:1-11.Google Scholar
  5. 5.
    Phillips, J. J., Chua, M. M., et al., 1999, Pathogenesis of chimeric MHV4/MHV-A59 recombinant viruses: the murine coronavirus spike protein is a major determinant of neurovirulence, J. Virol. 73:7752-7760.PubMedGoogle Scholar
  6. 6.
    Macnamara, K. C., Chua, M. M., et al., 2005, Contributions of the viral genetic background and a single amino acid substitution in an immunodominant CD8+ T-cell epitope to murine coronavirus neurovirulence,  J. Virol. 79:9108-9118.CrossRefPubMedGoogle Scholar
  7. 7.
    Murali-Krishna, K., Altman, J. D., et al., 1998, Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection, Immunity 8:177-187.CrossRefPubMedGoogle Scholar
  8. 8.
    Phillips, J. J., Chua, M. M., et al., 2002, Murine coronavirus spike glycoprotein mediates degree of viral spread, inflammation, and virus-induced immunopathology in the central nervous system, Virology 301:109-120.CrossRefPubMedGoogle Scholar
  9. 9.
    Rempel, J. D., Murray, S. J., et al., 2004, Differential regulation of innate and adaptive immune responses in viral encephalitis, Virology 318:381-392.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Katherine C. MacNamara
    • 1
  • Susan R. Weiss
    • 2
  1. 1.University of PennsylvaniaPhiladelphiaUSA
  2. 2.University of PennsylvaniaPhiladelphiaUSA

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