Mouse Hepatitis Virus Infection Activates the IRE1/XBP1 Pathway of the Unfolded Protein Response

  • John Bechill
  • Zhongbin Chen
  • Joseph W. Brewer
  • Susan C. Baker
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 581)


Unfold Protein Response Lipid Biosynthesis Mouse Hepatitis Virus XBP1 mRNA Double Membrane Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Gosert, R., Kanjanahaluethai, A., Egger, D., and Baker, S. C., 2002, RNA replication of mouse hepatitis virus takes place at double-membrane vesicles, J. Virol. 76:3697-3708.CrossRefPubMedGoogle Scholar
  2. 2.
    Rutkowski, D. T., and Kaufman, R. J., 2004, A trip to the ER: coping with stress, Trends Cell Biol. 14:20-28.CrossRefPubMedGoogle Scholar
  3. 3.
    Tardif, K. D., Mori, K., Kaufman, R. J., and Siddiqui, A., 2004, Hepatitis C virus suppresses the Ire-XBP1 pathway of the unfolded protein response, J. Biol. Chem. 279:17158-17164.CrossRefPubMedGoogle Scholar
  4. 4.
    Tardif, K. D., Waris, G., and Siddiqui, A., 2005, Hepatitis C virus, ER stress, and oxidative stress, Trends Microbiol. 13:159-163.CrossRefPubMedGoogle Scholar
  5. 5.
    Isler, J. A., Skalet A., and Alwine, J. C., 2005, Human cytomegalovirus infection activates and regulates the unfolded protein response, J. Virol. 79:6890-6899.CrossRefPubMedGoogle Scholar
  6. 6.
    Schiller, J. J., Kanjanhaluethai, A., and Baker, S. C., 1998, Processing of the coronavirus MHV-JHM polymerase polyprotein: identification of precursors and proteolytic products spanning 400 kilodaltons of ORF1a, J. Virol. 242:288-302.CrossRefGoogle Scholar
  7. 7.
    Gass, J. N., Gifford, N. M., and Brewer, J. W., 2002, Activation of an unfolded protein response during differentiation of antibody-secreting B cells, J. Biol. Chem. 277:49047-49054.CrossRefPubMedGoogle Scholar
  8. 8.
    Shaffer, A. L., Shapiro-Shelef, M., Iwakoshi, N. N., Lee, A., Qian, S., Zhao, H., Yu, X., Yang, L., Tan, B. K., Rosenwald, A., Hurt, E. M., Petroulakis, E., Sonenberg, N., Yewdell, J. W., Calame, K., Glimcher, L. H., and Staudt, L. M., 2004, XBP1, downstream of BIMP-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation, Immunity 21:81-93.CrossRefPubMedGoogle Scholar
  9. 9.
    Sriburi, R., Jackawski, S., Mori, K., and Brewer, J. W., 2004, XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endplasmic reticulum, J. Cell Biol. 167:35-41.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • John Bechill
    • 1
  • Zhongbin Chen
    • 2
  • Joseph W. Brewer
    • 3
  • Susan C. Baker
    • 4
  1. 1.Loyola University ChicagoMaywoodUSA
  2. 2.Loyola University Chicago Stritch School of MedicineMaywoodUSA
  3. 3.Loyola University ChicagoMaywoodUSA
  4. 4.Loyola University Chicago Stritch School of MedicineMaywoodUSA

Personalised recommendations