Structure, Expression, and Intracellular Localization of the SARS-CoV Accessory Proteins 7a and 7b

  • Andrew Pekosz
  • Scott R. Schaecher
  • Michael S. Diamond
  • Daved H. Fremont
  • Amy C. Sims
  • Ralph S. Baric
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 581)


Vero Cell Severe Acute Respiratory Syndrome Severe Acute Respiratory Syndrome Patient Severe Acute Respiratory Syndrome Coronavirus Severe Acute Respiratory Distress Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Drosten, C., Gunther, S., et al., 2003, Identification of a novel coronavirus in patients with severe acute respiratory syndrome, N. Engl. J. Med. 348:1967-1976.CrossRefPubMedGoogle Scholar
  2. 2.
    Rota, P. A., Oberste, M. S., et al., 2003, Characterization of a novel coronavirus associated with severe acute respiratory syndrome, Science 300:1394-1399.CrossRefPubMedGoogle Scholar
  3. 3.
    Snijder, E. J., Bredenbeek, P. J., et al., 2003, Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage, J. Mol. Biol. 331:991-1004.CrossRefPubMedGoogle Scholar
  4. 4.
    Fielding, B. C., Tan, Y.-J., et al., 2004, Characterization of a unique group-specific protein (U122) of the severe acute respiratory syndrome coronavirus, J. Virol. 78:7311-7318.CrossRefPubMedGoogle Scholar
  5. 5.
    Chen, Y. Y., Shuang, B., et al., 2005, The protein X4 of severe acute respiratory syndrome-associated coronavirus is expressed on both virus-infected cells and lung tissue of severe acute respiratory syndrome patients and inhibits growth of Balb/c 3T3 cell line, Chin. Med. J. (Engl.) 118:267-274.Google Scholar
  6. 6.
    Nelson, C. A., Pekosz, A., et al., 2005, Structure and intracellular targeting of the SARS-coronavirus Orf7a accessory protein, Structure (Camb.) 13:75-85.CrossRefGoogle Scholar
  7. 7.
    Tan, Y.-J., Fielding, B. C., et al., 2004, Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway, J. Virol. 78:14043-14047.CrossRefPubMedGoogle Scholar
  8. 8.
    McCown, M., Diamond, M. S., et al., 2003, The utility of siRNA transcripts produced by RNA polymerase i in down regulating viral gene expression and replication of negative- and positive-strand RNA viruses, Virology 313:514-524.CrossRefPubMedGoogle Scholar
  9. 9.
    Pekosz, A., and Lamb, R. A., 1999, Cell surface expression of biologically active influenza C virus HEF glycoprotein expressed from cDNA, J. Virol. 73:8808-8812.PubMedGoogle Scholar
  10. 10.
    Yount, B., Curtis, K. M., et al., 2003, Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus, Proc. Natl. Acad. Sci. USA 100:12995-13000.CrossRefPubMedGoogle Scholar
  11. 11.
    Giraudo, C. G., and Maccioni, H. J., 2003, Endoplasmic reticulum export of glycosyltransferases depends on interaction of a cytoplasmic dibasic motif with Sar1, Mol. Biol. Cell 14:3753-3766.CrossRefPubMedGoogle Scholar
  12. 12.
    Hussain, S., Pan, J. A., et al., 2005, Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus, J. Virol. 79:5288-5295.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Andrew Pekosz
    • 1
  • Scott R. Schaecher
    • 2
  • Michael S. Diamond
    • 3
  • Daved H. Fremont
    • 4
  • Amy C. Sims
    • 5
  • Ralph S. Baric
    • 6
  1. 1.Washington University School of MedicineSt. LouisUSA
  2. 2.Washington University School of MedicineSt. LouisUSA
  3. 3.Washington University School of MedicineSt. LouisUSA
  4. 4.Washington University School of MedicineSt. LouisUSA
  5. 5.University of North CarolinaChapel HillUSA
  6. 6.University of North CarolinaChapel HillUSA

Personalised recommendations