Viral Infections of the Respiratory Tract

  • George L. Kirkpatrick


Viral infections of the respiratory tract are responsible for large amounts of time lost from the workplace and significant morbidity and mortality in the very young and the very old. The worldwide pandemic of influenza in 1918 was alone responsible for nearly 30 million deaths in excess of those expected for influenza. Viral respiratory infections are the most frequent illnesses in human beings. The most frequent causes of respiratory infections are adenoviruses, influenza viruses, parainfluenza viruses, respiratory syncytial viruses, and rhinoviruses. Frequency and severity of infection are increased in the very young and the elderly, worsened by crowding and inhaling pollutants, and influenced by anatomic, metabolic, genetic, and immunologic disorders. Respiratory infections are the leading cause of death in children under age 5 living in underdeveloped countries.1


Chronic Obstructive pUlmonary Disease Influenza Virus Respiratory Syncytial Virus Sore Throat Common Cold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Denny FW. The clinical impact of human respiratory virus infections. Am J Respir Crit Care Med 1995; Oct. 152 (4PT2): 54–12.Google Scholar
  2. 2.
    Milinaric G. Epidemiological picture of respiratory viral infections in Croatia. Acta Med Iugosl 1991; 45: 203–11.Google Scholar
  3. 3.
    Jain A. An Indian hospital study of viral causes of acute respiratory infection in children. J Med Microbiol 1991; 35: 219–23.PubMedCrossRefGoogle Scholar
  4. 4.
    Falsey AR, Treanor JJ. Viral respiratory infections in the institutionalized elderly; clinical and epidemiology findings. J Am Geriatr Soc 1992; 40: 115–19.PubMedGoogle Scholar
  5. 5.
    Greenberg SB, Allen M. Respiratory viral infections in adults with and without chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000; 162: 167–73.PubMedGoogle Scholar
  6. 6.
    El-Sahly HM, Atmar RL. Spectrum of clinical illness in hospitalized patients with “common cold” virus infections. Clin Infect Dis 2000; 31: 96–100.PubMedCrossRefGoogle Scholar
  7. 7.
    Barenfanger J, Drake C. Clinical and financial benefits of rapid detection of respiratory viruses: an outcomes study. J Clin Microbiol 2000; 38: 2824–8.PubMedGoogle Scholar
  8. 8.
    Steininger C, Aberle SW. Early detection of acute rhinovirus infections by a rapid reverse transcription-PCR assay. J Clin Microbiol 2001; 39: 129–33.PubMedCrossRefGoogle Scholar
  9. 9.
    Tsai HP, Kuo PH. Respiratory viral infections among pediatric inpatients and outpatients in Taiwan from 1997 to 1999. J Clin Microbiol 2001; 39: 111–18.PubMedCrossRefGoogle Scholar
  10. 10.
    Glezen WP, Greenberg SB. Impact of respiratory virus infections on persons with chronic underlying conditions. JAMA 2000; 283: 499–505.PubMedCrossRefGoogle Scholar
  11. 11.
    Kim MR, Lee HR. Epidemiology of acute viral respiratory tract infections in Korean children. J Infect 2000; 41: 152–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Weigl JA, Puppe W. Epidemiological investigation of nine respiratory pathogens in hospitalized children in Germany using multiplex reverse-transcriptase polymerase chain reaction. Eur J Clin Microbiol Infect Dis 2000; 19: 336–43.PubMedCrossRefGoogle Scholar
  13. 13.
    Nasrallah GK, Meqdam MM. Prevalence of parainfluenza and influenza viruses amongst children with upper respiratory tract infection. Saudi Med J 2000; 21: 1024–9.PubMedGoogle Scholar
  14. 14.
    Hall CB, Douglas RG. Clinically useful method for the isolation of respiratory syncytial virus. J Infect Dis 1975; 131: 1–5.PubMedCrossRefGoogle Scholar
  15. 15.
    Irmen ICE, Kelleher JJ. Use of monoclonal antibodies for rapid diagnosis of respiratory viruses in a community hospital. Clin Diagn Lab Immunol 2000; 7: 396–403.PubMedGoogle Scholar
  16. 16.
    Kehl SC, Henrickson KJ. Evaluation of the hexaplex assay for detection of respiratory viruses in children. J Clin Microbiol 2001; 39: 1696–701.PubMedCrossRefGoogle Scholar
  17. 17.
    Shimizu H. The rapid detection kit based on neuraminidase activity of influenza virus. Nippon Rinsho 2000; 58: 2234–7.PubMedGoogle Scholar
  18. 18.
    Munoz FM, Glasso GJ. Current research on influenza and other respiratory viruses. Antiviral Res 2000; 46: 91–124.PubMedCrossRefGoogle Scholar
  19. 19.
    Laurichesse H, Dedman D. Epidemiological features of parainfluenza virus infections: laboratory surveillance in England and Wales, 1975–1997. Eur J Epidemiol 1999; 15: 475–84.PubMedCrossRefGoogle Scholar
  20. 20.
    Todd FJ, Drinka PJ. A serious outbreak of parainfluenza type 3 on a nursing unit. J Am Geriatr Soc 2000; 48: 1216–8.Google Scholar
  21. 21.
    Graman PS, Hall CB. Epidemiology and control of nosocomial viral infections. Infect Dis Clin North Am 1989; 3: 815–41.PubMedGoogle Scholar
  22. 22.
    Mygina N. The common cold as a trigger of asthma. Monaldi Arch Chest Dis 2000; 55: 478–83.Google Scholar
  23. 23.
    Van Kempen MJ, Bachert C. An update on the pathophysiology of rhinovirus upper respiratory tract infection. Rhinology 1999; 37: 97–103.PubMedGoogle Scholar
  24. 24.
    Hayden FG. Influenza virus and rhinovirus-related otitis media: potential for antiviral intervention. Vaccine 2000; 19 (suppl): 566–70.CrossRefGoogle Scholar
  25. 25.
    Rotbart HA. Antiviral therapy for enteroviruses and rhinoviruses. Antivir Chem Chemother 2000; 11: 261–71.PubMedGoogle Scholar
  26. 26.
    Isaacs D, Flowers D. Epidemiology of coronavirus respiratory infections. Arch Dis Child 1983; 58: 500–3.PubMedCrossRefGoogle Scholar
  27. 27.
    Falsey AR, McCann RM. The “common cold” in frail older persons: impact of rhinovirus and coronavirus in a senior day care center. J Am Geriatr Soc 1997; 45: 706–11.PubMedGoogle Scholar
  28. 28.
    Hyer RN, Howell MR. Cost-effectiveness analysis of reacquiring and using adenovirus types 4 and 7 vaccines in naval recruits. Am J Trop Med Hyg 2000; 62: 613–8.PubMedGoogle Scholar
  29. 29.
    Gwaltney JM Jr, Park J. Randomized controlled trial of clemastine fumarate for treatment of experimental rhinovirus colds. Clin Infect Dis 1996; 22: 656–62.PubMedCrossRefGoogle Scholar
  30. 30.
    Henneicke-Von Zepelin H. Efficacy and safety of a fixed combination phytomedicine in the treatment of the common cold: results of a randomized, double blind, placebo controlled, multicentre study. Curr Med Res Opin 1999; 15: 214–27.CrossRefGoogle Scholar
  31. 31.
    Jackson JL, Lesho E. Zinc and the common cold: a meta-analysis revisited. J Nutr 2000; 130 (55 suppl): 15125–55.Google Scholar
  32. 32.
    Schiff GM, Sherwood JR. Clinical activity of pleconaril in an experimentally induced coxsackievirus A21 respiratory infection. J Infect Dis 2000; 181: 2000–26.CrossRefGoogle Scholar
  33. 33.
    Meddiratta PK, Sharma KK. A review on recent development of common cold therapeutic agents. Indian J Med Sci 2000; 54: 485–90.Google Scholar
  34. 34.
    Raz E, Bursztyn M. Severe recurrent lupus laryngitis. Am J Med 1992; 92: 109–10.PubMedCrossRefGoogle Scholar
  35. 35.
    Macfarlane J, Holmes W. Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community. Thorax 2001; 56: 109–14.PubMedCrossRefGoogle Scholar
  36. 36.
    Falsey AR, Walsh EE. Respiratory syncytial virus infection in adults. Clin Microbiol Rev 2000; 13: 371–84.PubMedCrossRefGoogle Scholar
  37. 37.
    Munoz FM, Glasso GJ. Current research on influenza and other respiratory viruses Antiviral Res 2000; 46 (2): 91–124.Google Scholar

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© Springer Science+Business Media New York 2003

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  • George L. Kirkpatrick

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