Histoplasma Capsulatum: Mechanisms for Pathogenesis

  • Jamie Mittal
  • Maria G. Ponce
  • Inessa Gendlina
  • Joshua D. NosanchukEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 422)


Histoplasmosis, caused by the dimorphic environmental fungus Histoplasma capsulatum, is a major mycosis on the global stage. Acquisition of the fungus by mammalian hosts can be clinically silent or it can lead to life-threatening systemic disease, which can occur in immunologically intact or deficient hosts, albeit severe disease is more likely in the setting of compromised cellular immunity. H. capsulatum yeast cells are highly adapted to the mammalian host as they can effectively survive within intracellular niches in select phagocytic cells. Understanding the biological response by both the host and H. capsulatum will facilitate improved approaches to prevent and/or modify disease. This review presents our current understanding of the major pathogenic mechanisms involved in histoplasmosis.


Histoplasma capsulatum Histoplasmosis Intracellular survival Virulence Microbial pathogenesis 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Jamie Mittal
    • 1
  • Maria G. Ponce
    • 1
  • Inessa Gendlina
    • 2
  • Joshua D. Nosanchuk
    • 2
    • 3
    Email author
  1. 1.Department of Medicine (Infectious Diseases)Montefiore Medical CenterBronxUSA
  2. 2.Department of Medicine (Infectious Diseases)Albert Einstein College of MedicineBronxUSA
  3. 3.Department of Microbiology and ImmunologyAlbert Einstein College of MedicineBronxUSA

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