Molecular Control of HIV and SIV Latency
The HIV latent reservoirs are considered as the main hurdle to viral eradication. Numerous mechanisms lead to the establishment of HIV latency and act at the transcriptional and post-transcriptional levels. A better understanding of latency is needed in order to ultimately achieve a cure for HIV. The mechanisms underlying latency vary between patients, tissues, anatomical compartments, and cell types. From this point of view, simian immunodeficiency virus (SIV) infection and the use of nonhuman primate (NHP) models that recapitulate many aspects of HIV-associated latency establishment and disease progression are essential tools since they allow extensive tissue sampling as well as a control of infection parameters (virus type, dose, route, and time).
This project has received funding from the Belgian Fund for Scientific Research (FRS-FNRS, Belgium), the European Union’s Horizon 2020 research and innovation programme (grant agreement N° 691119 EU4HIVCURE H2020-MSCA-RISE-2015), the ANRS (France Recherche Nord & Sud Sida-HIV Hépatites), the “Fondation Roi Baudouin”, the NEAT Program, the Walloon Region (the Excellence Program “Cibles” and the “Fond de maturation” program), the ARC program (ULB) and the Internationale Brachet Stiftung (IBS). BVD and SB are postdoctoral fellows (ARC program and PDR project from the FRS-FNRS, respectively). CVL is “Directeur de Recherches” of the FRS-FNRS (Belgium).
- Fortin JF, Barat C, Beausejour Y, Barbeau B, Tremblay MJ (2004) Hyper-responsiveness to stimulation of human immunodeficiency virus-infected CD4+ T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-kappaB, and AP-1 induction. J Biol Chem 279:39520–39531CrossRefGoogle Scholar
- Kula A, Marcello A (2012) Dynamic post-transcriptional regulation of HIV-1 gene expression. Biology (Basel) 1:116–133Google Scholar
- Nguyen K, Das B, Dobrowolski C, Karn J (2017) Multiple histone lysine methyltransferases are required for the establishment and maintenance of HIV-1 latency. MBio 8Google Scholar
- Ravimohan S, Gama L, Barber SA, Clements JE (2010) Regulation of SIV mac 239 basal long terminal repeat activity and viral replication in macrophages: functional roles of two CCAAT/enhancer-binding protein beta sites in activation and interferon beta-mediated suppression. J Biol Chem 285:2258–2273CrossRefGoogle Scholar
- Wong RW, Mamede JI, Hope TJ (2015) The impact of nucleoporin mediated chromatin localization and nuclear architecture on HIV integration site selection. J VirolGoogle Scholar