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Role of Host Genes in Influenza Virus Replication

  • Megan L. Shaw
  • Silke Stertz
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 419)

Abstract

At every step of their replication cycle influenza viruses depend heavily on their host cells. The multifaceted interactions that occur between the virus and its host cell determine the outcome of the infection, including efficiency of progeny virus production, tropism, and pathogenicity. In order to understand viral disease and develop therapies for influenza it is therefore pertinent to study the intricate interplay between influenza viruses and their required host factors. Here, we review the current knowledge on host cell factors required by influenza virus at the different stages of the viral replication cycle. We also discuss the roles of host factors in zoonotic transmission of influenza viruses and their potential for developing novel antivirals.

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of MicrobiologyIcahn School of Medicine at Mount SinaiNew YorkUSA
  2. 2.Institute of Medical VirologyUniversity of ZurichZurichSwitzerland

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