Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases

  • Harald zur HausenEmail author
  • Timo Bund
  • Ethel-Michele de VilliersEmail author
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 407)


Red meat and dairy products have frequently been suggested to represent risk factors for certain cancers, chronic neurodegenerative diseases, and autoimmune and cardiovascular disorders. This review summarizes the evidence and investigates the possible involvement of infectious factors in these diseases. The isolation of small circular single-stranded DNA molecules from serum and dairy products of Eurasian Aurochs (Bos taurus)-derived cattle, obviously persisting as episomes in infected cells, provides the basis for further investigations. Gene expression of these agents in human cells has been demonstrated, and frequent infection of humans is implicated by the detection of antibodies in a high percentage of healthy individuals. Epidemiological observations suggest their relationship to the development multiple sclerosis, to heterophile antibodies, and to N-glycolylneuraminic acid (Neu5Gc) containing cell surface receptors.


Bovine zoonoses Multiple sclerosis Colon cancer N-glycolylneuraminic acid Hodgkin‘s disease 



We thank Prof. Dr. Hermann Müller (Veterinary Faculty, University of Leipzig, Germany) for providing the serum samples from cattle.

An unrestricted grant was provided by Oryx, München.


  1. Abbott RD, Ross GW, Petrovitch H, Masaki KH, Launer LJ, Nelson JS, White LR, Tanner CM (2016) Midlife milk consumption and substantia nigra neuron density at death. Neurology 86:512–519PubMedPubMedCentralCrossRefGoogle Scholar
  2. Abou-Dakn M, Scheele M, Strecker JR (2003) Vorbeugung von Brustkrebs durch Stillen? Zentralbl Gynäkol 125:48–52 ReviewGoogle Scholar
  3. Alisson-Silva F, Kawanishi K, Varki A (2016) Human risk of diseases associated with red meat intake: analysis of current theories and proposed role for metabolic incorporation of a non-human sialic acid. Mol Aspects Med pii: S0098-2997(16)30040-1. doi: 10.1016/j.mam.2016.07.002
  4. Amin M, Jeyaganth S, Fahmy N, Bégin LR, Aronson S, Jacobson S, Tanguay S, Kassouf W, Aprikian A (2008) Dietary habits and prostate cancer detection: a case-control study. Can Urol Assoc J 2:510–515PubMedPubMedCentralCrossRefGoogle Scholar
  5. Andersen V, Vogel U (2015) Interactions between meat intake and genetic variation in relation to colorectal cancer. Genes Nutr 10:448. doi: 10.1007/s12263-014-0448-9
  6. Aykan NF (2015) Red meat and colorectal cancer. Oncol Rev 9:b288 E-collectionGoogle Scholar
  7. Bagdonaite I, Nordén R, Joshi HJ, King SL, Vakhrushev SY, Olofsson S, Wandall HH (2016) Global mapping of O-glycosylation of varicella zoster virus, human cytomegalovirus, and Epstein-Barr virus. J Biol Chem 291:12014–12028PubMedPubMedCentralCrossRefGoogle Scholar
  8. Baron T, Biacabe AG, Arsac JN, Benestad S, Groschup MH (2007) Atypical transmissible spongiform encephalopathies (TSEs) in ruminants. Vaccine 25:5625–5630PubMedCrossRefGoogle Scholar
  9. Battaglia Richi E, Baumer B, Conrad B, Darioli R, Schmid A, Keller U (2015) Health risks associated with meat consumption: a review of epidemiological studies. Int J Vitam Nutr Res 85:70–78Google Scholar
  10. Bauer G, Höfler P, zur Hausen H (1982) Epstein-Barr virus induction by a serum factor. I. Induction and cooperation with additional inducers. Virology 121:184–194Google Scholar
  11. Bauer G, Götschl M, Höfler P (1991) Tumor-promoting activity of Epstein-Barr-virus-inducing factor transforming growth factor type beta (EIF/TGF-beta) is due to the induction of irreversible transformation. Int J Cancer 47:881–888PubMedCrossRefGoogle Scholar
  12. Beilfuss A, Sowa JP, Sydor S, Beste M, Bechmann LP, Schlattjan M, Syn WK, Wedemeyer I, Mathé Z, Jochum C, Gerken G, Gieseler RK, Canbay A (2015) Vitamin D counteracts fibrogenic TGF-β signalling in human hepatic stellate cells both receptor-dependently and independently. Gut 64:791–799PubMedCrossRefGoogle Scholar
  13. Bener A, Denic S, Galadari S (2001) Longer breast-feeding and protection against childhood leukaemia and lymphomas. Eur J Cancer 37:234–238PubMedCrossRefGoogle Scholar
  14. Bener A, Hoffmann GF, Afify Z, Rasul K, Tewfik I (2008) Does prolonged breastfeeding reduce the risk for childhood leukemia and lymphomas? Minerva Pediatr 60:155–161PubMedGoogle Scholar
  15. Boleij A, van Gelder MM, Swinkels DW, Tjalsma H (2011) Clinical importance of Streptococcus gallolyticus infection among colorectal cancer patients: systematic review and meta-analysis. Clin Infect Dis 53:870–878 ReviewGoogle Scholar
  16. Borkosky SS, Whitley C, Kopp-Schneider A, zur Hausen H, de Villiers EM (2012) Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis. PLoS One 7(2):e32160. doi: 10.1371/journal.pone.0032160
  17. Bosetti C, Micelotta S, Dal Maso L, Talamini R, Montella M, Negri E, Conti E, Franceschi S, La Vecchia C (2004) Food groups and risk of prostate cancer in Italy. Int J Cancer 110:424–428PubMedCrossRefGoogle Scholar
  18. Botsios S, Manuelidis L (2016) CJD and Scrapie require agent-associated nucleic acids for infection. J Cell Biochem 117(8):1947–1958 doi: 10.1002/jcb.25495
  19. Bouvard V, Loomis D, Guyton KZ, Grosse Y, Ghissassi FE, Benbrahim-Tallaa L, Guha N, Mattock H, Straif K, International Agency for Research on Cancer Monograph Working Group (2015) Carcinogenicity of consumption of red and processed meat. Lancet Oncol 16:1599–1600PubMedCrossRefGoogle Scholar
  20. Bovalino S, Charleson G, Szoeke C (2016) The impact of red and processed meat consumption on cardiovascular disease risk in women. Nutrition 32:349–354PubMedCrossRefGoogle Scholar
  21. Butcher J (1976) The distribution of multiple sclerosis in relation to the dairy industry and milk consumption. N Z Med J 83:427–430PubMedGoogle Scholar
  22. Caini S, Masala G, Gnagnarella P, Ermini I, Russell-Edu W, Palli D, Gandini S (2016) Food of animal origin and risk of non-Hodgkin lymphoma and multiple myeloma: a review of the literature and meta-analysis. Crit Rev Oncol Hematol 100:16–24PubMedCrossRefGoogle Scholar
  23. Cantorna MT, Mahon BD (2004) Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence. Expo Biol Med (Maywood) 229:1136–1142CrossRefGoogle Scholar
  24. Cao S, Wendl MC, Wyczalkowski MA, Wylie K, Ye K, Jayasinghe R, Xie M, Wu S, Niu B, Grubb R 3rd, Johnson KJ, Gay H, Chen K, Rader JS, Dipersio JF, Chen F, Ding L (2016) Divergent viral presentation among human tumors and adjacent normal tissues. Sci Rep 6:28294. doi: 10.1038/srep28294
  25. Carr PR, Walter V, Brenner H, Hoffmeister M (2016) Meat subtypes and their association with colorectal cancer: systematic review and meta-analysis. Int J Cancer 138:293–302 ReviewGoogle Scholar
  26. Castellon X, Bogdanova V (2016) Chronic inflammatory diseases and endothelial dysfunction. Aging Dis 7:81–89PubMedPubMedCentralCrossRefGoogle Scholar
  27. Chattoraj DK (2000) Control of plasmid DNA replication by iterons: no longer paradoxical. Mol Microbiol 37:467–476PubMedCrossRefGoogle Scholar
  28. Chen H, O’Reilly E, McCullough ML, Rodriguez C, Schwarzschild MA, Calle EE, Thun MJ, Ascherio A (2007) Consumption of dairy products and risk of Parkinson’s disease. Am J Epidemiol 165:998–1006PubMedPubMedCentralCrossRefGoogle Scholar
  29. Chen WW, Zhang X, Huang WJ (2016) Role of physical exercise in Alzheimer’s disease. Biomed Rep 4:403–407PubMedPubMedCentralCrossRefGoogle Scholar
  30. Choi Y, Song S, Song Y, Lee JE (2013) Consumption of red and processed meat and esophageal cancer risk: meta-analysis. World J Gastroenterol 19:1020–1029 ReviewGoogle Scholar
  31. Comoy EE, Mikol J, Luccantoni-Freire S, Correia E, Lescoutra-Etchegaray N, Durand V, Dehen C, Andreoletti O, Casalone C, Richt JA, Greenlee JJ, Baron T, Benestad SL, Brown P, Deslys JP (2015) Transmission of scrapie prions to primate after an extended silent incubation period. Sci Rep 5:11573. doi: 10.1038/srep11573
  32. Conradi S, Malzahn U, Paul F, Quill S, Harms L, Then Bergh F, Ditzenbach A, Georgi T, Heuschmann P, Rosche B (2013) Breastfeeding is associated with lower risk for multiple sclerosis. Mult Scler 19:553–558PubMedCrossRefGoogle Scholar
  33. Cross AJ, Lim U (2006) The role of dietary factors in the epidemiology of non-Hodgkin’s lymphoma. Leuk Lymphoma 47:2477–2487 ReviewGoogle Scholar
  34. Daniels JL, Olshan AF, Pollock BH, Shah NR, Stram DO (2002) Breast-feeding and neuroblastoma, USA and Canada. Cancer Causes Control 13:401–405PubMedCrossRefGoogle Scholar
  35. Davenport KA, Henderson DM, Bian J, Telling GC, Mathiason CK, Hoover EA (2015) Insights into chronic wasting disease and bovine spongiform encephalopathy species barriers by use of real-time conversion. J Virol 89:9524–9531PubMedPubMedCentralCrossRefGoogle Scholar
  36. de Bruyn JR, van Heeckeren R, Ponsioen CY, van den Brink GR, Löwenberg M, Bredenoord AJ, Frijstein G, D’Haens GRJ (2014) Vitamin D deficiency in Crohn’s disease and healthy controls: a prospective case-control study in the Netherlands. Crohns Colitis 8:1267–1273CrossRefGoogle Scholar
  37. Dechamma HJ, Natarajan C, Suryanarayanan VV, Rasool TJ (1998) Nucleotide sequence of DR-B exon of major histocompatibility complex from an Indian zebu cattle breed. Ind J Exp Biol 36:879–886Google Scholar
  38. Deicher H (1926) Über die Erzeugung heterospezifischer Hämagglutinine durch Injektion artfremden Serums. Z Hyg 106:561–579CrossRefGoogle Scholar
  39. Diack AB, Head MW, McCutcheon S, Boyle A, Knight R, Ironside JW, Manson JC, Will RG (2014) Variant CJD. 18 years of research and surveillance. Prion 8:286–295 ReviewGoogle Scholar
  40. Dou R, Ng K, Giovannucci EL, Manson JE, Qian ZR, Ogino S (2016) Vitamin D and colorectal cancer: molecular, epidemiological and clinical evidence. Br J Nutr 115:1643–1660PubMedPubMedCentralCrossRefGoogle Scholar
  41. D’Souza S, Levy E, Mack D, Israel D, Lambrette P, Ghadirian P, Deslandres C, Morgan K, Seidman EG, Amre DK (2008) Dietary patterns and risk for Crohn’s disease in children. Inflamm Bowel Dis 14:367–373PubMedCrossRefGoogle Scholar
  42. Dunmire SK, Hogquist KA, Balfour HH (2015) Infectious mononucleosis. Curr Top Microbiol Immunol 390:211–240 ReviewGoogle Scholar
  43. Durusoy R, Boffetta P, Mannetje A, Zaridze D, Szeszenia-Dabrowska N, Rudnai P, Lissowska J, Fabiánová E, Cassidy A, Mates D, Bencko V, Salajka F, Janout V, Fevotte J, Fletcher T, Brennan P (2006) Lung cancer risk and occupational exposure to meat and live animals. Int J Cancer 118:2543–2547PubMedCrossRefGoogle Scholar
  44. Dziewit L, Cegielski A, Romaniuk K, Uhrynowski W, Szych A, Niesiobedzki P, Zmuda-Baranowska MJ, Zdanowski MK, Bartosik D (2013) Plasmid diversity in arctic strains of Psychrobacter spp. Extremophiles 17(3):433–444PubMedPubMedCentralCrossRefGoogle Scholar
  45. Elwood PC, Morgan G, Pickering JE, Galante J, Weightman AL, Morris D, Kelson M, Dolwani S (2016) Aspirin in the treatment of cancer: reductions in metastatic spread and in mortality: a systematic review and meta-analyses of published studies. PLoS One 11(4):e0152402. doi: 10.1371/journal.pone.0152402. eCollection 2016 Review
  46. Epplein M, Zheng W, Li H, Peek RM Jr, Correa P, Gao J, Michel A, Pawlita M, Cai Q, Xiang YB, Shu XO (2014) Diet, Helicobacter pylori strain-specific infection, and gastric cancer risk among Chinese men. Nutr Cancer 66:550–557PubMedPubMedCentralCrossRefGoogle Scholar
  47. Epstein MM, Chang ET, Zhang Y, Fung TT, Batista JL, Ambinder RF, Zheng T, Mueller NE, Birmann BM (2015) Dietary pattern and risk of Hodgkin lymphoma in a population-based case-control study. Am J Epidemiol 182:405–416PubMedPubMedCentralCrossRefGoogle Scholar
  48. Etzold S, Bode L (2014) Glycan-dependent viral infection in infants and the role of human milk oligosaccharides. Curr Opin Virol 7:101–107 ReviewGoogle Scholar
  49. Farvid MS, Cho E, Chen WY, Eliassen AH, Willett WC (2015) Adolescent meat intake and breast cancer risk. Int J Cancer 136:1909–1920PubMedCrossRefGoogle Scholar
  50. Felmus MT, Patten BM, Swanke L (1976) Antecedent events in amyotrophic lateral sclerosis. Neurology 26:167–172PubMedCrossRefGoogle Scholar
  51. Ferrís i Tortajada J, Ortega García JA, García i Castell J, López Andreu JA, Berbel Tornero O, Crehuá Gaudiza E (2005) Risk factors for neuroblastoma [Article in Spanish]. An Pediatr (Barc) 63:50–60Google Scholar
  52. Fiorina L, Ricotti M, Vanoli A, Luinetti O, Dallera E, Riboni R, Paolucci S, Brugnatelli S, Paulli M, Pedrazzoli P, Baldanti F, Perfetti V (2014) Systematic analysis of human oncogenic viruses in colon cancer revealed EBV latency in lymphoid infiltrates. Infect Agent Cancer 9:18. doi: 10.1186/1750-9378-9-18
  53. Flynn KJ, Baxter NT, Schloss PD (2016) Metabolic and community synergy of oral bacteria in colorectal cancer. mSphere 1(3).pii:e00102-16. doi: 10.1128/mSphere.00102-16. eCollection. Review
  54. Fonseca-Nunes A, Jakszyn P, Agudo A (2014) Iron and cancer risk—a systematic review and meta-analysis of the epidemiological evidence. Cancer Epidemiol Biomarkers Prev 23:12–31PubMedCrossRefGoogle Scholar
  55. Funk M, Gunst K, Lucansky V, Müller H, zur Hausen H, de Villiers EM (2014) Isolation of protein-associated circular DNA from healthy cattle serum. Genome Announc 2(4):e00846-14Google Scholar
  56. Gołaszewska E, Kurowska E, Duk M, Kościelak J (2003) Paul-Bunnell antigen and a possible mechanism of formation of heterophile antibodies in patients with infectious mononucleosis. Acta Biochim Pol 50:1205–1211PubMedGoogle Scholar
  57. Gonia S, Tuepker M, Heisel T, Autran C, Bode L, Gale CA (2015) Human milk oligosaccharides inhibit Candida albicans invasion of human premature intestinal epithelial cells. J Nutr 145:1992–1998PubMedCrossRefGoogle Scholar
  58. González CA, López-Carrillo L (2010) Helicobacter pylori, nutrition and smoking interactions: their impact in gastric carcinogenesis. Scand J Gastroenterol 45:6–14 ReviewGoogle Scholar
  59. Gouveri E, Papanas N, Hatzitolios AI, Maltezos E (2011) Breastfeeding and diabetes. Curr Diabetes Rev 7:135–142 ReviewGoogle Scholar
  60. Graf R, Grüntzig K, Boo G, Hässig M, Axhausen KW, Fabrikant S, Welle M, Meier D, Guscetti F, Folkers G, Otto V, Pospischil A (2016) Swiss Feline Cancer Registry 1965–2008: the influence of sex, breed and age on tumour types and tumour locations. J Comp Pathol 154:195–210PubMedCrossRefGoogle Scholar
  61. Grant WB (2013) The role of milk protein in increasing risk of Parkinson’s disease. Eur J Epidemiol 28:357PubMedCrossRefGoogle Scholar
  62. Graves J, Grandhe S, Weinfurtner K, Krupp L, Belman A, Chitnis T, Ness J, Weinstock-Guttman B, Gorman M, Patterson M, Rodriguez M, Lotze T, Aaen G, Mowry EM, Rose JW, Simmons T, Casper TC, James J, Waubant E, US Network of Pediatric Multiple Sclerosis Centers (2014) Protective environmental factors for neuromyelitis optica. Neurology 83:1923–1929Google Scholar
  63. Greenop KR, Bailey HD, Miller M, Scott RJ, Attia J, Ashton LJ, Downie P, Armstrong BK, Milne E (2015) Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors. Nutr Cancer 67:431–441PubMedCrossRefGoogle Scholar
  64. Greenspan D, Greenspan JS, Conant M, Petersen V, Silverman S Jr, de Souza Y (1984) Oral “hairy” leucoplakia in male homosexuals: evidence of association with both papillomavirus and a herpes-group virus. Lancet 2(8407):831–834PubMedCrossRefGoogle Scholar
  65. Gu Y, Nieves JW, Stern Y, Luchsinger JA, Scarmeas N (2010) Food combination and Alzheimer disease risk: a protective diet. Arch Neurol 67:699–706PubMedPubMedCentralCrossRefGoogle Scholar
  66. Guise JM, Austin D, Morris CD (2005) Review of case-control studies related to breastfeeding and reduced risk of childhood leukemia. Pediatrics 116:e724–e731PubMedCrossRefGoogle Scholar
  67. Gunst K, zur Hausen H, de Villiers EM (2014) Isolation of bacterial plasmid-related replication-associated circular DNA from serum sample of a multiple sclerosis patient. Genome Announc 2(4):e00847-14Google Scholar
  68. Haahr S, Koch-Henriksen N, Møller-Larsen A, Eriksen LS, Andersen HM (1995) Increased risk of multiple sclerosis after late Epstein-Barr virus infection: a historical prospective study. Mult Scler 1:73–77PubMedCrossRefGoogle Scholar
  69. Halary S, Duraisamy R, Fancello L, Monteil-Bouchard S, Jardot P, Biagini P, Gouriet F, Raoult D, Desnues C (2016) Novel single-stranded DNA circular viruses in pericardial fluid of patient with recurrent pericarditis. Emerg Infect Dis 22:1839–1841PubMedPubMedCentralCrossRefGoogle Scholar
  70. Halme L, Loginov R, Arola J, Turunen U, Lautenschlager I (2013) HHV-6 antigen and HHV-6 DNA expression in sporadic adenomatous polyps of the colon. Scand J Gastroenterol 1448:1423–1427CrossRefGoogle Scholar
  71. Han YW (2015) Fusobacterium nucleatum: a commensal-turned pathogen. Curr Opin Microbiol 23:141–147 ReviewGoogle Scholar
  72. Hanganutziu M (1924) Hémagglutinines hétérogénétiques après injection de sérum de cheval. CR Séances Soc Biol 91:1457–1459Google Scholar
  73. Hanley-Bowdoin L, Bejarano ER, Robertson D, Mansoor S (2013) Geminiviruses: masters in redirecting and reprogramming plant processes. Nature Rev Microbiol 11:777–788CrossRefGoogle Scholar
  74. Harrison PM, Chan HS, Prusiner SB, Cohen FE (2001) Conformational propagation with prion-like characteristics in a simple model of protein folding. Protein Sci 10:819–835PubMedPubMedCentralCrossRefGoogle Scholar
  75. Heilbronn R, zur Hausen H (1989). A subset of herpes simplex virus replication genes induces DNA amplification within the host cell genome. J Virol 63:3683–3692Google Scholar
  76. Heilbronn R, Bürkle A, Stephan S, zur Hausen H (1990) The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification. J Virol 64:3012–3018Google Scholar
  77. Hendrix DV, Newkirk KM (2014) Expression of epidermal growth factor receptor and human epidermal growth factor receptor 2 in periocular squamous cell carcinomas of horses. Am J Vet Res 75:912–917. doi: 10.2460/ajvr.75.10.912
  78. Hernández ÁR, Boada LD, Almeida-González M, Mendoza Z, Ruiz-Suárez N, Valeron PF, Camacho M, Zumbado M, Henríquez-Hernández LA, Luzardo OP (2015) An estimation of the carcinogenic risk associated with the intake of multiple relevant carcinogens found in meat and charcuterie products. Sci Total Environ 514:33–41PubMedCrossRefGoogle Scholar
  79. Higashi H, Ikuta K, Ueda S, Kato S, Hirabayashi Y, Matsumoto M, Naiki M (1984) Characterization of N-glycolyneuraminic acid-containing glycosphingolipids from a Marek’s disease lymphoma-derived chicken cell line, MSB1, as tumor-associated heterophile Hanganutziu-Deicher antigens. J Biochem 95:785–794PubMedCrossRefGoogle Scholar
  80. Hou JK, Abraham B, El-Serag H (2011) Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am J Gastroenterol 106:563–573PubMedCrossRefGoogle Scholar
  81. Hu H, Luo ML, Desmedt C, Nabavi S, Yadegarynia S, Hong A, Konstantinopoulos PA, Gabrielson E, Hines-Boykin R, Pihan G, Yuan X, Sotirious C, Dittmer DP, Fingeroth JD, Wulf GM (2016) Epstein-Barr Virus infection of mammary epithelial cells promotes malignant transformation. EBioMedicine pii:S2352-3964(16)30209-2. doi: 10.1016/j.ebiom.2016.05.025
  82. Huisman MH, Seelen M, van Doormaal PT, de Jong SW, de Vries JH, van der Kooi AJ, de Visser M, Schelhaas HJ, van den Berg LH, Veldink JH (2015) Effect of presymptomatic body mass index and consumption of fat and alcohol on amyotrophic lateral sclerosis. JAMA Neurol 72:1155–1162PubMedCrossRefGoogle Scholar
  83. Hurt C, Tammaro D (2007) Diagnostic evaluation of mononucleosis-like illnesses. Am J Med 120:911.e1-8Google Scholar
  84. Huxley RR, Ansary-Moghaddam A, Clifton P, Czernichow S, Parr CL, Woodward M (2009) The impact of dietary and lifestyle risk factors on risk of colorectal cancer: a quantitative overview of the epidemiological evidence. Int J Cancer 125:171–180PubMedCrossRefGoogle Scholar
  85. Inoue S, Sato C, Kitajima K (2010) Extensive enrichment of N-glycolylneuraminic acid in extracellular sialoglycoproteins abundantly synthesized and secreted by human cancer cells. Glycobiology 20:752–762PubMedCrossRefGoogle Scholar
  86. Ip S, Chung M, Raman G, Chew P, Magula N, DeVine D, Trikalinos T, Lau J (2007) Breastfeeding and maternal and infant health outcomes in developed countries. Evid Rep Technol Assess (Full Rep) 153:1–186Google Scholar
  87. Jans H, Heltberg A, Raun NE (1982) Circulating immune complexes and complement in the course of multiple sclerosis. Acta Neurol Scand 66:488–496PubMedCrossRefGoogle Scholar
  88. Jantchou P, Morois S, Clavel-Chapelon F, Boutron-Ruault MC, Carbonnel F (2010) Animal protein intake and risk of inflammatory bowel disease: the E3 N prospective study. Am J Gastroenterol 105:2195–2201PubMedCrossRefGoogle Scholar
  89. Ji J, Sundquist J, Sundquist K (2015) Lactose intolerance and risk of lung, breast and ovarian cancers: aetiological clues from a population-based study in Sweden. Br J Cancer 112:149–152PubMedCrossRefGoogle Scholar
  90. Jiang W, Ju C, Jiang H, Zhang D (2014) Dairy foods intake and risk of Parkinson’s disease: a dose-response meta-analysis of prospective cohort studies. Eur J Epidemiol 29:613–619PubMedCrossRefGoogle Scholar
  91. Juste RA (2010) Crohn’s disease and ruminant farming. Got lactase? Med Hypotheses 75:7–13PubMedCrossRefGoogle Scholar
  92. Kabat GC, Cross AJ, Park Y, Schatzkin A, Hollenbeck AR, Rohan TE, Sinha R (2009) Meat intake and meat preparation in relation to risk of postmenopausal breast cancer in the NIH-AARP diet and health study. Int J Cancer 124:2430–2435PubMedPubMedCentralCrossRefGoogle Scholar
  93. Kang H, Cha ES, Choi GJ, Lee WJ (2014) Amyotrophic lateral sclerosis and agricultural environments: a systematic review. J Korean Med Sci 29:1610–1617PubMedPubMedCentralCrossRefGoogle Scholar
  94. Kangro HO, Chong SK, Hardiman A, Heath RB, Walker-Smith JA (1990) A prospective study of viral and mycoplasma infections in chronic inflammatory bowel disease. Gastroenterology 98:549–553PubMedCrossRefGoogle Scholar
  95. Kao TH, Chen S, Huang CW, Chen CJ, Chen BH (2014) Occurrence and exposure to polycyclic aromatic hydrocarbons in kindling-free-charcoal grilled meat products in Taiwan. Food Chem Toxicol 71:149–158PubMedCrossRefGoogle Scholar
  96. Khan ZM, Liu Y, Neu U, Gilbert M, Ehlers B, Feizi T, Stehle T (2014) Crystallographic and glycan microarray analysis of human polyomavirus 9 VP1 identifies N-glycolyl neuraminic acid as a receptor candidate. J Virol 88:6100–6111PubMedPubMedCentralCrossRefGoogle Scholar
  97. Khuder SA, Mutgi AB, Schaub EA, Tano BD (1999) Meta-analysis of Hodgkin’s disease among farmers. Scand J Work Environ Health 25(5):436–441PubMedCrossRefGoogle Scholar
  98. Knize MG, Salmon CP, Pais P, Felton JS (1999) Food heating and the formation of heterocyclic aromatic amine and polycyclic aromatic hydrocarbon mutagens/carcinogens. Adv Exp Med Biol 459:179–193 ReviewGoogle Scholar
  99. Kolonel LN (2001) Fat, meat, and prostate cancer. Epidemiol Rev 23:72–81 ReviewGoogle Scholar
  100. Krupovic M, Ghabrial SA, Jiang D, Varsani A (2016) Genomoviridae: a new family of widespread single-stranded DNA viruses. Arch Virol 161:2633–2643PubMedCrossRefGoogle Scholar
  101. Lamberto I, Gunst K, Müller H, zur Hausen H, de Villiers EM (2014) Mycovirus-like DNA virus sequences from cattle serum, human brain, and serum from multiple sclerosis patients. Genome Announc 2(4):e00848-14Google Scholar
  102. Larsson SC, Orsini N (2014) Red meat and processed meat consumption and all-cause mortality: a meta-analysis. Am J Epidemiol 179:282–289PubMedCrossRefGoogle Scholar
  103. Larsson SC, Wolk A (2012) Red and processed meat consumption and risk of pancreatic cancer: meta-analysis of prospective studies. Br J Cancer 106:603–607PubMedPubMedCentralCrossRefGoogle Scholar
  104. Le Guern R, Wallet F, Vega E, Courcol RJ, Loiez C (2014) Psychrobacter sanguinis: an unusual bacterium for nosocomial meningitis. J Clin Microbiol 52:3475–3477PubMedPubMedCentralCrossRefGoogle Scholar
  105. Leunda A, Van Vaerenbergh B, Baldo A, Roels S, Herman P (2013) Laboratory activities involving transmissible spongiform encephalopathy causing agents: risk assessment and biosafety recommendations in Belgium. Prion 7:420–433 ReviewGoogle Scholar
  106. Li Z, Zheng Z, Ruan J, Li Z, Tzeng CM (2016) Chronic Inflammation links cancer and Parkinson’s disease. Front Aging Neurosci 8:126. doi: 10.3389/fnagi.2016.00126. eCollection 2016 Review
  107. Limongi D, Baldelli S (2016) Redox imbalance and viral infections in neuro-degenerative diseases. Oxid Med Cell Longev 2016:6547248. doi: 10.1155/2016/6547248
  108. Linos E, Willett WC, Cho E, Colditz G, Frazier LA (2008) Red meat consumption during adolescence among premenopausal women and risk of breast cancer. Cancer Epidemiol Biomarkers Prev 17:2146–2151PubMedPubMedCentralCrossRefGoogle Scholar
  109. Lippi G, Mattiuzzi C, Cervellin G (2016) Meat consumption and cancer risk: a critical review of published meta-analyses. Crit Rev Oncol Hematol 97:1–14PubMedCrossRefGoogle Scholar
  110. Lloyd-Puryear M, Wallace D, Baldwin T, Hollis DG (1991) Meningitis caused by Psychrobacter immobilis in an infant. J Clin Microbiol 29:2014–2042Google Scholar
  111. Löfling J, Lyi SM, Parrish CR, Varki A (2013) Canine and feline parvoviruses preferentially recognize the non-human cell surface sialic acid N-glycolylneuraminic acid. Virology 440:89–96PubMedPubMedCentralCrossRefGoogle Scholar
  112. Lohman-Payne B, Slyker JA, Moore S, Maleche-Obimbo E, Wamalwa DC, Richardson BA, Rowland-Jones S, Mbori-Ngacha D, Farquhar C, Overbaugh J, John-Stewart G (2012) Breast milk cellular HIV-specific interferon γ responses are associated with protection from peripartum HIV transmission. AIDS 26:2007–2016PubMedPubMedCentralCrossRefGoogle Scholar
  113. Luethy D, Habecker P, Murphy B, Nolen-Walston R (2016) Computed tomographic appearance of melanomas in the equine head: 13cases. Vet Radiol Ultrasound 57:246–252CrossRefGoogle Scholar
  114. Machado NO, Chopra PJ, Hamdani AA (2010) Crohn’s disease of the appendix with enterocutaneous fistula post-appendicectomy: an approach to management. N Am J Med Sci 2:158–161PubMedPubMedCentralGoogle Scholar
  115. Małolepsza EB (2008) Modeling of protein misfolding in disease. Methods Mol Biol 443:297–330 ReviewGoogle Scholar
  116. Malosse D, Perron H (1993) Correlation analysis between bovine populations, other farm animals, house pets, and multiple sclerosis prevalence. Neuroepidemiology 12:15–27PubMedCrossRefGoogle Scholar
  117. Malosse D, Perron H, Sasco A, Seigneurin JM (1992) Correlation between milk and dairy product consumption and multiple sclerosis prevalence: a worldwide study. Neuroepidemiology 11:304–312PubMedCrossRefGoogle Scholar
  118. Malykh YN, Schauer R, Shaw L (2001) N-Glycolylneuraminic acid in human tumours. Biochimie 83:623–634 ReviewGoogle Scholar
  119. Manuelidis L (2011) Nuclease resistant circular DNAs copurify with infectivity in scrapie and CJD. J Neurovirol 17:131–145PubMedCrossRefGoogle Scholar
  120. Manuelidis L (2013) Infectious particles, stress, and induced prion amyloids: a unifying perspective. Virulence 4:373–383PubMedPubMedCentralCrossRefGoogle Scholar
  121. Martin RM, Gunnell D, Owen CG, Smith GD (2005a) Breast-feeding and childhood cancer: a systematic review with meta-analysis. Int J Cancer 117:1020–1031 ReviewGoogle Scholar
  122. Martin RM, Middleton N, Gunnell D, Owen CG, Smith GD (2005b) Breast-feeding and cancer: the Boyd Orr cohort and a systematic review with meta-analysis. J Natl Cancer Inst 97:1446–1457PubMedCrossRefGoogle Scholar
  123. Masaki M, Kano K, Merrick JM, Milgrom F (1981) Studies on Paul-Bunnell (P-B) antigen-antibody system. II. P-B antigens in extracts of lymphoma-leukemia spleens and pathologic sera. J Immunol 127:5–8PubMedGoogle Scholar
  124. Matos E, Brandani A (2002) Review on meat consumption and cancer in South America. Mutat Res 506–507:243–249 ReviewGoogle Scholar
  125. Maytsetseg B, Riichiro I (2006) Changes and actual state of Mongolian meat market and distribution system: a case study of Ulaanbaatar City’s “Khuchit Shondor” Food Market. International Association of Agricultural Economists, Annual Meeting, August 12–18, 2006 Queensland, Australia.
  126. Mayuri M, Garg V, Mukherji C, Aggarwal D, Ganguly S (2012) Bovine milk usage and feeding practices for infants in India. Ind J Public Health 56:75–81CrossRefGoogle Scholar
  127. McElroy MC, Bassett HF (2010) Mammary carcinoma in a ewe. J Vet Diagn Invest 22:1006–1007PubMedCrossRefGoogle Scholar
  128. McNally RJ, Parker L (2006) Environmental factors and childhood acute leukemias and lymphomas. Leuk Lymphoma 47:583–598 ReviewGoogle Scholar
  129. Meeker S, Seamons A, Maggio-Price L, Paik J (2016) Protective links between vitamin D, inflammatory bowel disease and colon cancer. World J Gastroenterol 22:933–948PubMedPubMedCentralCrossRefGoogle Scholar
  130. Mehta SK, Pierson DL, Cooley H, Dubow R, Lugg D (2000) Epstein-Barr virus reactivation associated with diminished cell-mediated immunity in antarctic expeditioners. J Med Virol 61:235–240PubMedCrossRefGoogle Scholar
  131. Merlo DF, Rossi L, Pellegrino C, Ceppi M, Cardellino U, Capurro C, Ratto A, Sambucco PL, Sestito V, Tanara G, Bocchini V (2008) Cancer incidence in pet dogs: findings of the Animal Tumor Registry of Genoa, Italy. J Vet Intern Med 22:976–984PubMedCrossRefGoogle Scholar
  132. Meyer T, Brink U, Unterberg C, Stöhr S, Kreuzer H, Buchwald AB (1994) Expression of meta-vinculin in human coronary arteriosclerosis is related to the histological grade of plaque formation. Atherosclerosis 111:111–119PubMedCrossRefGoogle Scholar
  133. Micha R, Michas G, Mozaffarian D (2012) Unprocessed red and processed meats and risk of coronary artery disease and type 2 diabetes—an updated review of the evidence. Curr Atheroscler Rep 14:515–524PubMedPubMedCentralCrossRefGoogle Scholar
  134. Michels KB, Trichopoulos D, Rosner BA, Hunter DJ, Colditz GA, Hankinson SE, Speizer FE, Willett WC (2001) Being breastfed in infancy and breast cancer incidence in adult life: results from the two nurses’ health studies. Am J Epidemiol 153:275–283PubMedCrossRefGoogle Scholar
  135. Miller MA, Moore GE, Bertin FR, Kritchevsky JE (2016) What’s new in old horses? Postmortem diagnoses in mature and aged equids. Vet Pathol 53:390–398PubMedCrossRefGoogle Scholar
  136. Mistry N, Abdel-Fahim R, Samaraweera A, Mougin O, Tallantyre E, Tench C, Jaspan T, Morris P, Morgan PS, Evangelou N (2015) Imaging central veins in brain lesions with 3-T T2*-weighted magnetic resonance imaging differentiates multiple sclerosis from microangiopathic brain lesions. Mult Scler 22:1289–1296. doi: 10.1177/1352458515616700 Epub 2015
  137. Monti L, Cattaneo TM, Orlandi M, Curadi MC (2015) Capillary electrophoresis of sialylated oligosaccharides in milk from different species. J Chromatogr A 1409:288–291PubMedCrossRefGoogle Scholar
  138. Munger KL, Chitnis T, Frazier AL, Giovannucci E, Spiegelman D, Ascherio A (2011) Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. J Neurol 258:479–485PubMedCrossRefGoogle Scholar
  139. Munson L, Moresco A (2007) Comparative pathology of mammary gland cancers in domestic and wild animals. Breast Dis 28:7–21PubMedCrossRefGoogle Scholar
  140. Ng PS, Böhm R, Hartley-Tassell LE, Steen JA, Wang H, Lukowski SW, Hawthorne PL, Trezise AE, Coloe PJ, Grimmond SM, Haselhorst T, von Itzstein M, Paton AW, Paton JC, Jennings MP (2014) Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors. Nat Commun 5:5750PubMedPubMedCentralCrossRefGoogle Scholar
  141. Nishimaki T, Kano K, Milgrom F (1979) Paul-Bunnell antigen in malignancies and rheumatoid arthritis. Int Arch Allergy Appl Immunol 60:115–119PubMedCrossRefGoogle Scholar
  142. Norat T, Bingham S, Ferrari P, Slimani N, Jenab M, Mazuir M, Overvad K, Olsen A, Tjønneland A, Clavel F, Boutron-Ruault MC, Kesse E, Boeing H, Bergmann MM, Nieters A, Linseisen J, Trichopoulou A, Trichopoulos D, Tountas Y, Berrino F, Palli D, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Engeset D, Lund E, Skeie G, Ardanaz E, González C, Navarro C, Quirós JR, Sanchez MJ, Berglund G, Mattisson I, Hallmans G, Palmqvist R, Day NE, Khaw KT, Key TJ, San Joaquin M, Hémon B, Saracci R, Kaaks R, Riboli E (2005) Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J Natl Cancer Inst 97:906–916PubMedPubMedCentralCrossRefGoogle Scholar
  143. Ortiz-Alcántara JM, Segura-Candelas JM, Garcés-Ayala F, Gonzalez-Durán E, Rodríguez-Castillo A, Alcántara-Pérez P, Wong-Arámbula C, González-Villa M, León-Ávila G, García-Chéquer AJ, Diaz-Quiñonez JA, Méndez-Tenorio A, Ramírez-González JE (2016) Fatal Psychrobacter sp. infection in a pediatric patient with meningitis identified by metagenomic next-generation sequencing in cerebrospinal fluid. Arch Microbiol 198:129–135PubMedCrossRefGoogle Scholar
  144. Otaegui D, Mostafavi S, Bernard CC, Lopez de Munain A, Mousavi P, Oksenberg JR, Baranzini SE (2007) Increased transcriptional activity of milk-related genes following the active phase of experimental autoimmune encephalomyelitis and multiple sclerosis. J Immunol 179:4074–4082PubMedCrossRefGoogle Scholar
  145. Owston MA, Ramsay EC, Rotstein DS (2008) Neoplasia in felids at the Knoxville Zoological Gardens, 1979–2003. J Zoo Wildl Med 39:608–613PubMedCrossRefGoogle Scholar
  146. Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Willett WC, Hu FB (2011) Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis. Am J Clin Nutr 94:1088–1096PubMedPubMedCentralCrossRefGoogle Scholar
  147. Pan A, Sun Q, Bernstein AM, Schulze MB, Manson JE, Stampfer MJ, Willett WC, Hu FB (2012) Red meat consumption and mortality: results from 2 prospective cohort studies. Arch Intern Med 172:555–563PubMedPubMedCentralCrossRefGoogle Scholar
  148. Park M, Ross GW, Petrovitch H, White LR, Masaki KH, Nelson JS, Tanner CM, Curb JD, Blanchette PL, Abbott RD (2005) Consumption of milk and calcium in midlife and the future risk of Parkinson disease. Neurology 64:1047–1051PubMedCrossRefGoogle Scholar
  149. Paul JR, Bunnell WW (1932) The presence of heterophile antibodies in infectious mononucleosis. Am J Med Sci 183:91–104CrossRefGoogle Scholar
  150. Pedditizi E, Peters R, Beckett N (2016) The risk of overweight/obesity in mid-life and late life for the development of dementia: a systematic review and meta-analysis of longitudinal studies. Age Ageing 45:14–21CrossRefGoogle Scholar
  151. Peterson JA, Patton S, Hamosh M (1998) Glycoproteins of the human milk fat globule in the protection of the breast-fed infant against infections. Biol Neonate 74:143–162 ReviewGoogle Scholar
  152. Peterson R, Cheah WY, Grinyer J, Packer N (2013) Glycoconjugates in human milk: protecting infants from disease. Glycobiology 23(12):1425–1438PubMedCrossRefGoogle Scholar
  153. Phan TG, Mori D, Deng X, Rajindrajith S, Ranawaka U, Fan Ng TF, Bucardo-Rivera F, Orlandi P, Ahmed K, Delwart E (2015) Small circular single stranded DNA viral genomes in unexplained cases of human encephalitis, diarrhea, and in untreated sewage. Virology 482:98–104PubMedPubMedCentralCrossRefGoogle Scholar
  154. Pisacane A, Impagliazzo N, Russo M, Valiani R, Mandarini A, Florio C, Vivo P (1994) Breast feeding and multiple sclerosis. BMJ 308:1411–1412PubMedPubMedCentralCrossRefGoogle Scholar
  155. Price AB, Morson BC (1975) Inflammatory bowel disease: the surgical pathology of Crohn’s disease and ulcerative colitis. Hum Pathol 6:7–29 ReviewGoogle Scholar
  156. Prusiner SB (1982) Novel proteinaceous infectious particles cause scrapie. Science 216:136–144PubMedCrossRefGoogle Scholar
  157. Ragnedda G, Leoni S, Parpinel M, Casetta I, Riise T, Myhr KM, Wolfson C, Pugliatti M (2015) Reduced duration of breastfeeding is associated with a higher risk of multiple sclerosis in both Italian and Norwegian adult males: the EnvIMS study. J Neurol 262:1271–1277PubMedCrossRefGoogle Scholar
  158. Richardson AK, Currie MJ, Robinson BA, Morrin H, Phung Y, Pearson JF, Anderson TP, Potter JD, Walker LC (2015) Cytomegalovirus and Epstein-Barr virus in breast cancer. PLoS One 10(2):e0118989. doi: 10.1371/journal.pone.0118989. eCollection 2015 Review
  159. Rizvi I, Choudhury NR, Tuteja N (2015) Insights into the functional characteristics of geminivirus rolling-circle replication initiator protein and its interaction with host factors affecting viral DNA replication. Arch Virol 160:375–387PubMedCrossRefGoogle Scholar
  160. Rohrmann S, Linseisen J, Nöthlings U, Overvad K, Egeberg R, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Cottet V, Pala V, Tumino R, Palli D, Panico S, Vineis P, Boeing H, Pischon T, Grote V, Teucher B, Khaw KT, Wareham NJ, Crowe FL, Goufa I, Orfanos P, Trichopoulou A, Jeurnink SM, Siersema PD, Peeters PH, Brustad M, Engeset D, Skeie G, Duell EJ, Amiano P, Barricarte A, Molina-Montes E, Rodríguez L, Tormo MJ, Sund M, Ye W, Lindkvist B, Johansen D, Ferrari P, Jenab M, Slimani N, Ward H, Riboli E, Norat T, Bueno-de-Mesquita HB (2013) Meat and fish consumption and risk of pancreatic cancer: results from the European Prospective Investigation into Cancer and Nutrition. Int J Cancer 132:617–624PubMedCrossRefGoogle Scholar
  161. Roizman B (1974) Herpesviruses, latency and cancer: a biochemical approach. J Reticuloendothel Soc 15:312–321 ReviewGoogle Scholar
  162. Røsjø E, Lossius A, Abdelmagid N, Lindstrøm JC, Kampman MT, Jørgensen L, Sundström P, Olsson T, Steffensen LH, Torkildsen Ø, Holmøy T (2016) Effect of high-dose vitamin D3 supplementation on antibody responses against Epstein-Barr virus in relapsing-remitting multiple sclerosis. Mult Scler pii:1352458516654310Google Scholar
  163. Sadeghian M, Saneei P, Siassi F, Esmaillzadeh A (2016) Vitamin D status in relation to Crohn’s disease: meta-analysis of observational studies. Nutrition 32:505–514 ReviewGoogle Scholar
  164. Samraj AN, Pearce OM, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A (2015) A red meat-derived glycan promotes inflammation and cancer progression. Proc Natl Acad Sci U S A 112:542–547PubMedCrossRefGoogle Scholar
  165. Sepcić J, Mesaros E, Materljan E, Sepić-Grahovac D (1993) Nutritional factors and multiple sclerosis in Gorski Kotar, Croatia. Neuroepidemiology 12:234–240PubMedCrossRefGoogle Scholar
  166. Sharma RL, Godara R, Thilagar MB (2011) Epizootiology, pathogenesis and immunoprophylactic trends to control tropical bubaline fasciolosis: an overview. J Parasit Dis 35:1–9PubMedPubMedCentralCrossRefGoogle Scholar
  167. Silva MA, Menezes J, Dionne S, Levy E, Amre DK, Seidman EG (2012) Herpes simplex virus-1 infection of colonic explants as a model of viral-induced activation of Crohn’s disease. J Crohns Colitis 6:454–463PubMedCrossRefGoogle Scholar
  168. Simmons MM, Spiropoulos J, Hawkins SA, Bellworthy SJ, Tongue SC (2008) Approaches to investigating transmission of spongiform encephalopathies in domestic animals using BSE as an example. Vet Res 39:34PubMedCrossRefGoogle Scholar
  169. Simon MW (1998) Anorexia and failure to grow associated with Epstein-Barr virus infection. J Ky Med Assoc 96:13–15PubMedGoogle Scholar
  170. Sipponen T, Turunen U, Lautenschlager I, Nieminen U, Arola J, Halme L (2011) Human herpesvirus 6 and cytomegalovirus in ileocolonic mucosa in inflammatory bowel disease. Scand J Gastroenterol 46:1324–1333PubMedCrossRefGoogle Scholar
  171. Söderberg-Nauclér C (2006) Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer? J Intern Med 259:219–246 ReviewGoogle Scholar
  172. Song X, Yu H, Chen X, Lasanajak Y, Tappert MM, Air GM, Tiwari VK, Cao H, Chokhawala HA, Zheng H, Cummings RD, Smith DF (2011) A sialylated glycan microarray reveals novel interactions of modified sialic acids with proteins and viruses. J Biol Chem 286:31610–31622PubMedPubMedCentralCrossRefGoogle Scholar
  173. Song P, Lu M, Yin Q, Wu L, Zhang D, Fu B, Wang B, Zhao Q (2014) Red meat consumption and stomach cancer risk: a meta-analysis. J Cancer Res Clin Oncol 140:979–992PubMedCrossRefGoogle Scholar
  174. Springer SA, Diaz SL, Gagneux P (2014) Parallel evolution of a self-signal: humans and new world monkeys independently lost the cell surface sugar Neu5Gc. Immunogenetics 66:671–674PubMedPubMedCentralCrossRefGoogle Scholar
  175. Steel O, Kraberger S, Sikorski A, Young LM, Catchpole RJ, Steven AJ, Ladley JJ, Coray DS, Stainton D, Dayaram A, Julian L, van Bysterveldt K, Varsani A (2016) Circular replication-associated protein encoding DNA viruses identified in the faecal matter of various animals in New Zealand. Infect Genet Evol 43:151–164PubMedCrossRefGoogle Scholar
  176. Stuebe A (2009) The risks of not breastfeeding for mothers and infants. Rev Obstet Gynecol 2:222–231PubMedPubMedCentralGoogle Scholar
  177. Sugimura T, Wakabayashi K, Nakagama H, Nagao M (2004) Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci 95:290–299 ReviewGoogle Scholar
  178. Takimori S, Shimaoka H, Furukawa J, Yamashita T, Amano M, Fujitani N, Takegawa Y, Hammarström L, Kacskovics I, Shinohara Y, Nishimura S (2011) Alteration of the N-glycome of bovine milk glycoproteins during early lactation. FEBS J 278:3769–3781PubMedCrossRefGoogle Scholar
  179. Tan IL, van Schijndel RA, Pouwels PJ, van Walderveen MA, Reichenbach JR, Manoliu RA, Barkhof F (2000) MR venography of multiple sclerosis. AJNR Am J Neuroradiol 21:1039–1042PubMedGoogle Scholar
  180. Tao Q, Wang B, Zheng Y, Jiang X, Pan Z, Ren J (2015) Vitamin D prevents the intestinal fibrosis via induction of vitamin D receptor and inhibition of transforming growth factor-beta1/Smad3 pathway. Dig Dis Sci 60:868–875PubMedCrossRefGoogle Scholar
  181. Taylor EF, Burley VJ, Greenwood DC, Cade JE (2007) Meat consumption and risk of breast cancer in the UK Woman’s Cohort Study. Br J Cancer 96:1139–1146PubMedPubMedCentralCrossRefGoogle Scholar
  182. Taylor RE, Gregg CJ, Padler-Karavani V, Ghaderi D, Yu H, Huang S, Sorensen RU, Chen X, Inostroza J, Nizet V, Varki A (2010) Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid. J Exp Med 207:1637–1646PubMedPubMedCentralCrossRefGoogle Scholar
  183. Thacker EL, Mirzaei F, Ascherio A (2006) Infectious mononucleosis and risk for multiple sclerosis: a meta-analysis. Ann Neurol 59:499–503PubMedCrossRefGoogle Scholar
  184. Torki M, Gholamrezaei A, Mirbagher L, Danesh M, Kheiri S, Emami MH (2015) Vitamin D deficiency associated with disease activity in patients with inflammatory bowel diseases. Dig Dis Sci 60:3085–3091PubMedCrossRefGoogle Scholar
  185. Urashima T, Odaka G, Asakuma S, Uemura Y, Goto K, Senda A, Saito T, Fukuda K, Messer M, Oftedal OT (2009) Chemical characterization of oligosaccharides in chimpanzee, bonobo, gorilla, orangutan, and siamang milk or colostrum. Glycobiology 19:499–508PubMedCrossRefGoogle Scholar
  186. Weichert S, Koromyslova A, Singh BK, Hansman S, Jennewein S, Schroten H, Hansman GS (2016) Structural basis for norovirus inhibition by human milk oligosaccharides. J Virol 90:4843–4848PubMedPubMedCentralCrossRefGoogle Scholar
  187. Wergeland S, Myhr KM, Løken-Amsrud KI, Beiske AG, Bjerve KS, Hovdal H, Midgard R, Kvistad SS, Holmøy T, Riise T, Torkildsen Ø (2016) Vitamin D, HLA-DRB1 and Epstein-Barr virus antibody levels in a prospective cohort of multiple sclerosis patients. Eur J Neurol 23:1064–1070PubMedCrossRefGoogle Scholar
  188. Whitley C, Gunst K, Müller H, Funk M, zur Hausen H, de Villiers EM (2014) Novel replication-competent circular DNA molecules from healthy cattle serum, milk, and multiple sclerosis-affected human brain tissue. Genome Announc 2(4):e00849-14Google Scholar
  189. Winer S, Astsaturov I, Cheung RK, Schrade K, Gunaratnam L, Wood DD, Moscarello MA, O'Connor P, McKerlie C, Becker DJ, Dosch HM (2001) T cells of multiple sclerosis patients target a common environmental peptide that causes encephalitis in mice. J Immunol 166:4751–4756PubMedCrossRefGoogle Scholar
  190. Wise LA, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Trichopoulos D, Hampton JM, Egan KM (2009) Exposure to breast milk in infancy and risk of breast cancer. Cancer Causes Control 20:1083–1090PubMedPubMedCentralCrossRefGoogle Scholar
  191. Womack J, Jimenez M (2015) Common questions about infectious mononucleosis. Am Fam Physician 91:372–376PubMedGoogle Scholar
  192. Xue XJ, Gao Q, Qiao JH, Zhang J, Xu CP, Liu J (2014) Red and processed meat consumption and the risk of lung cancer: a dose-response meta-analysis of 33 published studies. Int J Clin Exp Med 7:1542–1553PubMedPubMedCentralGoogle Scholar
  193. Zerr P, Vollath S, Palumbo-Zerr K, Tomcik M, Huang J, Distler A, Beyer C, Dees C, Gela K, Distler O, Schett G, Distler JH (2015) Vitamin D receptor regulates TGF-β signalling in systemic sclerosis. Ann Rheum Dis 74(3):e20. doi: 10.1136/annrheumdis-2013-204378. Epub 2014 Jan 21
  194. Zhang Y (2013) Epidemiology of esophageal cancer. World J Gastroenterol 19:5598–5606 ReviewGoogle Scholar
  195. Zhang L, de Waard M, Verheijen H, Boeren S, Hageman JA, van Hooijdonk T, Vervoort J, van Goudoever JB, Hettinga K (2016) Changes over lactation in breast milk serum proteins involved in the maturation of immune and digestive system of the infant. J Proteomics pii:S1874-391, 9(16) 30028-8Google Scholar
  196. Zhang W, Li L, Deng X, Blümel J, Nübling CM, Hunfeld A, Baylis SA, Delwart E (2016b) Viral nucleic acids in human plasma pools. Transfusion 56:2248–2255PubMedCrossRefGoogle Scholar
  197. zur Hausen H (2001) Proliferation-inducing viruses in non-permissive systems as possible causes of human cancers. Lancet 357:381–384Google Scholar
  198. zur Hausen H (2009) The search for infectious agents of human cancers: where and why. Nobel lecture. Virology 392:1–10Google Scholar
  199. zur Hausen H (2012) Red meat consumption and cancer: reasons to suspect involvement of bovine infectious factors in colorectal cancer. Int J Cancer 130:2475–2483Google Scholar
  200. zur Hausen H (2015) What do breast and CRC cancers and MS have in common? Nat Rev Clin Oncol 12:569–570Google Scholar
  201. zur Hausen H, de Villiers EM (2014a) Cancer “causation” by infections—individual contributions and synergistic networks. Sem Oncol 41:868–883Google Scholar
  202. zur Hausen H, de Villiers EM (2014b) Prenatal infections with subsequent immune tolerance could explain the epidemiology of common childhood cancers. World Cancer Report IARC Lyon, pp 261–265Google Scholar
  203. zur Hausen H, de Villiers EM (2015) Dairy cattle serum and milk factors contributing to the risk of colon and breast cancers. Int J Cancer 137:959–967Google Scholar
  204. zur Hausen H, de Villiers EM (2016) Risikofaktoren für Krebs und MS in Kuhmilch und Rindfleisch? Biol Unserer Zeit 46:26–31. doi: 10.1002/bluz.201610583
  205. Zwart SR, Mehta SK, Ploutz-Snyder R, Bourbeau Y, Locke JP, Pierson DL, Smith SM (2011) Response to vitamin D supplementation during antarctic winter is related to BMI, and supplementation can mitigate Epstein-Barr virus reactivation. J Nutr 141:692–697PubMedCrossRefGoogle Scholar

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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Deutsches KrebsforschungszentrumHeidelbergGermany

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