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Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases

  • Harald zur Hausen
  • Timo Bund
  • Ethel-Michele de Villiers
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 407)

Abstract

Red meat and dairy products have frequently been suggested to represent risk factors for certain cancers, chronic neurodegenerative diseases, and autoimmune and cardiovascular disorders. This review summarizes the evidence and investigates the possible involvement of infectious factors in these diseases. The isolation of small circular single-stranded DNA molecules from serum and dairy products of Eurasian Aurochs (Bos taurus)-derived cattle, obviously persisting as episomes in infected cells, provides the basis for further investigations. Gene expression of these agents in human cells has been demonstrated, and frequent infection of humans is implicated by the detection of antibodies in a high percentage of healthy individuals. Epidemiological observations suggest their relationship to the development multiple sclerosis, to heterophile antibodies, and to N-glycolylneuraminic acid (Neu5Gc) containing cell surface receptors.

Keywords

Bovine zoonoses Multiple sclerosis Colon cancer N-glycolylneuraminic acid Hodgkin‘s disease 

Notes

Acknowledgements

We thank Prof. Dr. Hermann Müller (Veterinary Faculty, University of Leipzig, Germany) for providing the serum samples from cattle.

An unrestricted grant was provided by Oryx, München.

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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Deutsches KrebsforschungszentrumHeidelbergGermany

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