pp 1-23 | Cite as

Behavioral and Physical Activity Interventions for HAND

  • Jessica L. Montoya
  • Brook Henry
  • David J. MooreEmail author
Part of the Current Topics in Behavioral Neurosciences book series


Approximately 30–50% of persons living with HIV manifest some degree of neurocognitive impairment. Even mild-to-moderate forms of HIV-associated neurocognitive disorders (HAND) can result in difficulties with everyday functioning, such as suboptimal medication adherence and impaired driving. Despite the pervasive presence and consequences of HAND, there is a significant unmet need to develop effective behavioral strategies to reduce the incidence and consequences of HAND. Although there is an absence of evidence-based behavioral interventions specific to HAND, the literature reviewed in this chapter suggest the following modifiable lifestyle factors as intervention targets: physical activity, diet, sleep, and antiretroviral medication adherence. Adoption and maintenance of these healthy lifestyle factors may reduce inflammation and oxidative stress, which, in turn, may reduce the incidence and/or severity of HAND.


Antiretroviral therapy adherence Cognition Diet Exercise Nutrition Physical activity Sleep 


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Jessica L. Montoya
    • 1
  • Brook Henry
    • 1
  • David J. Moore
    • 1
    • 2
    Email author
  1. 1.Department of PsychiatryUniversity of California San DiegoLa JollaUSA
  2. 2.HIV Neurobehavioral Research ProgramSan DiegoUSA

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