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Prefrontal Contributions to Attention and Working Memory

  • Zahra Bahmani
  • Kelsey Clark
  • Yaser Merrikhi
  • Adrienne Mueller
  • Warren Pettine
  • M. Isabel Vanegas
  • Tirin Moore
  • Behrad NoudoostEmail author
Chapter
Part of the Current Topics in Behavioral Neurosciences book series

Abstract

The processes of attention and working memory are conspicuously interlinked, suggesting that they may involve overlapping neural mechanisms. Working memory (WM) is the ability to maintain information in the absence of sensory input. Attention is the process by which a specific target is selected for further processing, and neural resources directed toward that target. The content of WM can be used to direct attention, and attention can in turn determine which information is encoded into WM. Here we discuss the similarities between attention and WM and the role prefrontal cortex (PFC) plays in each. First, at the theoretical level, we describe how attention and WM can both rely on models based on attractor states. Then we review the evidence for an overlap between the areas involved in both functions, especially the frontal eye field (FEF) portion of the prefrontal cortex. We also discuss similarities between the neural changes in visual areas observed during attention and WM. At the cellular level, we review the literature on the role of prefrontal DA in both attention and WM at the behavioral and neural levels. Finally, we summarize the anatomical evidence for an overlap between prefrontal mechanisms involved in attention and WM. Altogether, a summary of pharmacological, electrophysiological, behavioral, and anatomical evidence for a contribution of the FEF part of prefrontal cortex to attention and WM is provided.

Keywords

Attention Dopamine Working memory 

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Copyright information

© Springer Nature Switzerland AG 2018

Authors and Affiliations

  • Zahra Bahmani
    • 1
  • Kelsey Clark
    • 2
  • Yaser Merrikhi
    • 3
    • 4
  • Adrienne Mueller
    • 5
    • 6
  • Warren Pettine
    • 7
  • M. Isabel Vanegas
    • 2
  • Tirin Moore
    • 5
    • 6
  • Behrad Noudoost
    • 2
    Email author
  1. 1.School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM)TehranIran
  2. 2.Department of Ophthalmology and Visual SciencesUniversity of UtahSalt Lake CityUSA
  3. 3.Department of Physiology & PharmacologyThe Brain and Mind Institute, University of Western OntarioLondonCanada
  4. 4.Robarts Research Institute, University of Western OntarioLondonCanada
  5. 5.Department of NeurobiologyStanford UniversityStanfordUSA
  6. 6.Howard Hughes Medical Institute, Stanford UniversityStanfordUSA
  7. 7.Center for Neural Science, New York UniversityNew YorkUSA

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