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Achieving High Levels of Selectivity for Kinase Inhibitors

  • Laurent SchioEmail author
  • Herve Minoux
Chapter
  • 6 Downloads
Part of the Topics in Medicinal Chemistry book series

Abstract

Kinase inhibitors have emerged over the last two decades as one of the most prolific therapeutic classes of agents to reach clinical trials and to obtain marketing approval, mainly for oncology. We describe here the methodologies that we performed for hit and lead finding in the context of four internal projects to identify selective inhibitors for development or preclinical pharmacological evaluation.

Keywords

Kinase inhibitors Ligands Oncology Protein conformations Selectivity Targeted therapy 

Notes

Compliance with Ethical Standards

Conflict of Interest: All authors are employees of Sanofi R&D and may hold stock in the same. All authors declare no conflict of interest.

Funding: All studies were funded only by Sanofi R&D.

Ethical Approval: This chapter does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent: No human studies are reported; no informed consent required.

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© Springer Nature Switzerland AG 2020

Authors and Affiliations

  1. 1.Integrated Drug Discovery, SanofiVitry-sur-SeineFrance

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