Intramolecular Arylation of 2-Nitrobenzenesulfonamides: A Route to Diverse Nitrogenous Heterocycles

  • Eva Schütznerová
  • Viktor KrchňákEmail author
Part of the Topics in Heterocyclic Chemistry book series (TOPICS, volume 52)


In addition to being an integral component of numerous drugs, 2- and 4-nitrobenzenesulfonyl (Nos) groups are used as protecting/activating agents for the selective alkylation of primary amines. 2-Nos amides are also useful intermediates for the synthesis of fused nitrogenous heterocycles. This chapter focuses on the use of 2-Nos amides as intramolecular arylation agents and on the application of C- and N-aryl derivatives for the synthesis of diverse heterocycles in the solid phase.


Arylation Heterocycles Nitrobenzenesulfonamides Solid-phase synthesis 



This research was supported by the Department of Chemistry and Biochemistry, University of Notre Dame, by National program of Sustainability (LO1304), and research grant 16-06446S from the Czech Science Foundation (GACR).


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Faculty of Medicine, Institute of Molecular and Translation MedicinePalacký UniversityOlomoucCzech Republic
  2. 2.Department of Organic Chemistry, Faculty of SciencePalacký UniversityOlomoucCzech Republic
  3. 3.Department of Chemistry and BiochemistryUniversity of Notre DameNotre DameUSA

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