pp 1-35 | Cite as

Biomatrices for Heart Regeneration and Cardiac Tissue Modelling In Vitro

  • I. Kulvinskiene
  • R. Aldonyte
  • R. Miksiunas
  • A. Mobasheri
  • Daiva BironaiteEmail author
Part of the Advances in Experimental Medicine and Biology book series


Cardiac muscle is the hardest working muscle in the body, pumping approximately 70 g of blood with every heartbeat, circulating 9500 l of blood daily and contracting over 3 billion times during the average human’s life. Heart failure – a heterogeneous syndrome – is a major and increasing health care problem worldwide and a leading cause of hospitalization and morbidity in elderly. Adequate heart tissue regeneration in human is lacking. Challenges to engineer heart tissue and employ it in vitro or in regenerative medicine remain to be solved. First of all, cardiac tissue bioengineering requires robust and powerful cells capable of differentiating into cardiomyogenic lineages in combination with effective, safe and highly specialized biomaterials, hydrogels and/or scaffolds for recreating the native extracellular microenvironment. Advances in stem cell and biomaterial science already provided an increasing array of cell resources, their cultivation technologies and biomatrices for efficient and safe cardiac tissue reconstruction. In order to develop new cardiac tissue mimicking technologies in vitro, it is necessary to analyze the advantages and drawbacks of already established biosystems. Therefore, in this paper, we provide a comprehensive overview of recently employed cells, 2D and 3D biomatrices for cardiac tissue engineering and review the current state-of-the-art in this field as well as future directions.


Biomaterials Biomatrices Cardiac muscle Regenerative medicine Remodeling Tissue engineering 



adipose tissue-derived stem cells


albumin electrospun fibers and gold nanorods


bone morphogenetic protein 4


cardiosphere-derived cells




carbon nanotubes


cardiac progenitor cells


cardio progenitor spheres


cardiovascular diseases


embryonic bodies


extracellular matrix


embryonic stem cells




granulocyte colony-stimulating factor


glycogen synthase kinase 3


heart failure


human foreskin fibroblasts


hepatocyte growth factor


intracoronary infusion


insulin-like growth factor




induced pluripotent stem cells


left ventricular ejection fraction


mouse embryonic fibroblast


magnetic resonance imaging


mesenchymal stem/stromal cells








platelet-derived growth factor receptor-alpha


polyethylene glycol-fibrinogen hydrogel


poly(glycolic acid) or poly-glycolide


pH low insertion peptide


poly N-isopropylacrylamide


poly-lactic acid


pluripotent stem cells


retrograde coronary venous infusion

Sca − 1

stem cell antigen-1


stromal-derived growth factor 1


transendocardial injection


transforming growth factor β


vascular endothelial growth factor



This work was supported by the project: Studies of the regenerative potential and mechanoptosis of the human heart primary cardiospheres, (No. S-MIP-17-13).


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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • I. Kulvinskiene
    • 1
  • R. Aldonyte
    • 1
  • R. Miksiunas
    • 1
  • A. Mobasheri
    • 1
    • 2
    • 3
  • Daiva Bironaite
    • 1
    Email author
  1. 1.Department of Regenerative MedicineState Research Institute Centre for Innovative MedicineVilniusLithuania
  2. 2.Research Unit of Medical Imaging, Physics and TechnologyFaculty of Medicine University of OuluOuluFinland
  3. 3.Department of Orthopedics and Department of Rheumatology and Clinical ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands

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