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Depression and Serum Content of Serotonin in Adult Patients with Atopic Dermatitis

  • Andrzej Kazimierz JaworekEmail author
  • Magdalena Jaworek
  • Marta Makara-Studzińska
  • Krystyna Szafraniec
  • Zbigniew Doniec
  • Jacek Szepietowski
  • Anna Wojas-Pelc
  • Mieczyslaw Pokorski
Chapter
  • 54 Downloads
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1271)

Abstract

Atopic dermatitis (AD) is a chronic skin disease with the etiology not yet conclusively established. Recent reports demonstrate the role of serotonin (5-hydroxytryptamine; 5-HT) in the pathogenesis of AD. The aim of this study was to investigate the relationship between the serum content of serotonin and depression in adult patients suffering from severe AD. There were 31 patients of the median age of 41 years enrolled into the study, who suffered from AD since childhood, and a control group that consisted of 14 healthy subjects. AD was diagnosed on the basis of Hanifin and Rajka criteria. The severity of skin lesions was assessed with the SCORing Atopic Dermatitis (SCORAD) index and that of depression with the Montgomery-Åsberg Depression Rating Scale (MADRS) questionnaire. We found that all of the patients with severe AD characterized by SCORAD >50 had depression. Depression was classified as mild and moderate according to the MADRS score. Serotonin content was significantly lower in the patients with severe AD (MADRS >12), and there was an adverse relation between the serotonin content and the score of depression, the features not noticed in the control group. We conclude that severe AD, as expressed by the intensification of skin lesions, associates with depression and with the lowering of serum serotonin content. The findings point attention to the cognitive and affective problems in AD patients which could worsen the course of the skin disease.

Keywords

Affective symptoms Atopic dermatitis Depression Serotonin Skin lesions 

Notes

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Bioethics Committee of the Medical College of the Jagiellonian University in Cracow, Poland.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

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Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Andrzej Kazimierz Jaworek
    • 1
    Email author
  • Magdalena Jaworek
    • 2
  • Marta Makara-Studzińska
    • 3
  • Krystyna Szafraniec
    • 4
  • Zbigniew Doniec
    • 5
  • Jacek Szepietowski
    • 6
  • Anna Wojas-Pelc
    • 1
  • Mieczyslaw Pokorski
    • 7
  1. 1.Department of DermatologyJagiellonian University Medical CollegeCracowPoland
  2. 2.Department of Physiotherapy, Faculty of Health SciencesJagiellonian University Medical CollegeCracowPoland
  3. 3.Department of Health Psychology, Faculty of Health SciencesJagiellonian University Medical CollegeCracowPoland
  4. 4.Department of Epidemiology and Population Studies, Institute of Public Health, Faculty of Health SciencesJagiellonian University Medical CollegeCracowPoland
  5. 5.Department of Pneumology, Institute of Tuberculosis and Lung DisordersField Unit in RabkaRabkaPoland
  6. 6.Department of Dermatology, Venereology and AllergologyWroclaw Medical UniversityWroclawPoland
  7. 7.Department of PhysiotherapyOpole Medical SchoolOpolePoland

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